DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Epac and Ralgds

DIOPT Version :9

Sequence 1:	NP_001097202.2	Gene:	Epac / 35588	FlyBaseID:	FBgn0085421	Length:	1006	Species:	Drosophila melanogaster
Sequence 2:	XP_006233812.1	Gene:	Ralgds / 29622	RGDID:	3533	Length:	907	Species:	Rattus norvegicus

Alignment Length:	676	Identity:	135/676 - (19%)
Similarity:	228/676 - (33%)	Gaps:	192/676 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   444 VDKEHFNRILRDVEANTLRLQE-----------HGKDVLVLERVAKQRGQHSAFKYTVMSGTPAK 497
            :.:|..|.::..:....::|..           ..:..|.|....|.|        ||.:||..|
  Rat    67 IGEELINGVIYSISLRKVQLHPGATKGQRWLGCENESALNLYETCKVR--------TVKAGTLEK 123

  Fly   498 MLEHLLETRLGQSVGGMDPFLDDFLLTHIVFMPVVQLVDEL-ANYFHCDA--------------H 547
            ::|||:....|..:.    ::..||.|:..|....|::|.| ..|..|||              .
  Rat   124 LVEHLVPAFQGSDLS----YVTVFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYGCILPYSS 184

  Fly   548 EDAQTPEDREYIINFKKRVIQFMQKWVMAVRHAAFEEPSVCDF--IEDLAAEVEADPDLNEETSI 610
            ||. .|:|:     .|..:...:..|:........:.|   ||  ::.|.|.|:.:...::....
  Rat   185 EDG-GPQDQ-----LKNAISSILGTWLDQYSEDFCQPP---DFPCLKQLVAYVQLNMPGSDLERR 240

  Fly   611 VHNVLTQMARYQ----EDRNQNAGQKWKLPPNGQ----PICLFSGNATPSKTVIRPDDDIIFR-- 665
            .|.:|.|:...:    |....:......|.|..|    |..|.:.:...:.|.:|....:...
  Rat   241 AHLLLAQLEDLEPSEVEPEALSPAPVLSLKPASQLEPAPALLLTPSRAVASTPVREPAPVPVLAS 305

  Fly   666 ---VYCADHTYCTLRFPMHTTAELIKACAAD-----KLQLNRGP-------EDLVLVEVKSNGER 715
               |..|......|..|:.....|..|...|     .|.|...|       ....|.|...||
  Rat   306 SPVVAPASELEPALEPPLDPEPTLAPAPELDPTVSQSLHLEPAPVPAPALEPSWPLPETTENG-- 368

  Fly   716 SVFKDNDVSIPTGLSLNGRLFVSVKDHLDALTQLQEQECPTEGVDIDLEILSTKEL-AYHITLFE 779
                                 :..|.||                     :|...:| |...||.:
  Rat   369 ---------------------LCAKPHL---------------------LLFPPDLVAEQFTLMD 391

  Fly   780 WDLFWAVHEYELLYHTFG-----RHHFGK--ITANLDVFLRRFNEVQYWIVTELVSTPSL--SKR 835
            .:||..|    :.||..|     |...||  :...:...:.:||.|...::|..:...|:  |.|
  Rat   392 AELFKKV----VPYHCLGSIWSQRDKKGKEHLAPTIRATVAQFNNVANCVITTCLGDQSMKASDR 452

  Fly   836 VGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRN 900
            ..:|..:|::|..|:..:|.::.:|::..|.:.|:.||::|||::.....::||:...:.....|
  Rat   453 ARVVEHWIEVARECRVLKNFSSLYAILSALQSNAIHRLKKTWEEVSRGSFRVFQKLSEIFSDENN 517

  Fly   901 HRAYRVFV-------------------------GKLQPPLIPFMPLLLKDMTFAHEGNKTSLDG- 939
            :...|..:                         |.:| ..:|::...|.|:.......|..|.|
  Rat   518 YSLSRELLIKEGTSKFATLEMNPRRTQRRQKETGVIQ-GTVPYLGTFLTDLVMLDTAMKDYLYGR 581

  Fly   940 LVNFEKMHMMAQTMRTIRFCRS-----------------RSLG-------------LEPPSPKSE 974
            |:||||.....:.:..|:..:|                 |::|             |||||..:.
  Rat   582 LINFEKRRKEFEVIAQIKLLQSACNNYSIVPEEHFGAWFRAMGRLSEAESYNLSCELEPPSESAS 646

  Fly   975 GEVRSYISSF---RVIDNQRVLTAMS 997
            ..:||..|:.   |..|.|...|.:|
  Rat   647 NTLRSKKSTAIVKRWSDRQAPSTELS 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Epac	NP_001097202.2	Crp	28..>146	CDD:223736
		CAP_ED	36..146	CDD:237999
		DEP_Epac	199..330	CDD:239884
		CAP_ED	352..463	CDD:237999	2/18 (11%)
		Crp	373..525	CDD:223736	18/91 (20%)
		RasGEF_N	489..594	CDD:279012	29/121 (24%)
		UBQ	665..>714	CDD:294102	13/65 (20%)
		RasGEF	766..1002	CDD:214539	68/301 (23%)
Ralgds	XP_006233812.1	RasGEFN	112..248	CDD:214571	36/156 (23%)
		DUF3275	205..344	CDD:288521	24/141 (17%)
		RasGEF	375..637	CDD:238087	56/287 (20%)
		RalGDS_RA	791..876	CDD:176351
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810