Protein Alignment Epac and Rasgrp1

DIOPT Version :10

• Sequence 1: NP_001097202.2
• Gene: Epac / 35588
• FlyBaseID: FBgn0085421
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: NP_062084.2
• Gene: Rasgrp1 / 29434
• RGDID: 3539
• Length: 795
• Species: Rattus norvegicus
• Alignment Length: 398
• Identity: 89/398 - (22%)
• Similarity: 154/398 - (38%)
• Gaps: 73/398 - (18%)

  Fly   565 RVIQFMQKWVMAVRHAAFEEPSVCDFIEDLAAEVEADPDLNEETSIVHNVLTQ------------ 617
            ::.||  :.::::.|.| :..|:.|.|:......:||.:|.....::..:||.
  Rat    43 QITQF--RMMVSLGHLA-KGASLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIIISSAELLQ 104

  Fly   618 --MARYQEDRNQNAGQKWKLPPNGQPICLFSGNATPSKTVIRPDDDIIFRVYCADHTYCTLRFPM 680
              |..|::          .|..|...|||                     ..|....|....|.:
  Rat   105 KLMNLYKD----------ALEKNSPGICL---------------------KICYFVRYWITEFWI 138

  Fly   681 HTTAELIKACAADKLQLNRGPEDLVLVEVKSNGERSVFKDNDVSIPTGLSLNGRLFVSVKDHLDA 745
            ....:.......::.|      ||    ||:|||.|.....|.:     .:|.|      |....
  Rat   139 MFKMDASLTSTMEEFQ------DL----VKANGEESHCHLIDTT-----QINSR------DWSRK 182

  Fly   746 LTQ-LQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHEYELLYHTFGRHHFGKITANLD 809
            ||| ::........|.:..:.|..:||:.|:|..|:..|..:...:  |..:..:...|....::
  Rat   183 LTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSD--YQNYLVNSCVKENPTME 245

  Fly   810 VFLRRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQ 874
            ..:...|.:..|:...::|.|:...|..:..|||.:|....:.||.|...||:.||.:.::|||:
  Rat   246 RSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLK 310

  Fly   875 QTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFVGKLQPPLIPFMPLLLKDMTFAHEGNKTSL-D 938
            :|...:|.:..|:..|...|:...||:..||...|:.....||.:.:.|||:...:|.....| |
  Rat   311 ETSSHVPHEINKVLGEMTELLSSCRNYDNYRRAYGECTHFKIPILGVHLKDLISLYEAMPDYLED 375

  Fly   939 GLVNFEKM 946
            |.||.:|:
  Rat   376 GKVNVQKL 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Epac	NP_001097202.2	CAP_ED	36..146	CDD:237999
		DEP_Epac	199..330	CDD:239884
		CAP_ED	352..463	CDD:237999
		RasGEF_N	489..594	CDD:459873	7/28 (25%)
		Ubl1_cv_Nsp3_N-like	652..>722	CDD:475130	12/69 (17%)
		RasGEF	766..1002	CDD:214539	50/182 (27%)
Rasgrp1	NP_062084.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37
		RasGEFN	54..176	CDD:214571	30/168 (18%)
		Ras exchanger motif region, required for transforming activity. /evidence=ECO:0000250	57..110		10/53 (19%)
		RasGEF	201..437	CDD:214539	50/185 (27%)
		FRQ1	<471..527	CDD:444056
		C1_RASGRP1	540..594	CDD:410410
		Suppress the PT region-mediated translocation to plasma membrane. /evidence=ECO:0000250	686..694
		PT region, mediates the BCR-dependent translocation to plasma membrane. /evidence=ECO:0000250	717..795
		cc_RasGRP1_C	737..791	CDD:412086