DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Epac and CG7369

DIOPT Version :9

Sequence 1:	NP_001097202.2	Gene:	Epac / 35588	FlyBaseID:	FBgn0085421	Length:	1006	Species:	Drosophila melanogaster
Sequence 2:	NP_649415.2	Gene:	CG7369 / 2768961	FlyBaseID:	FBgn0037188	Length:	680	Species:	Drosophila melanogaster

Alignment Length:	214	Identity:	58/214 - (27%)
Similarity:	102/214 - (47%)	Gaps:	25/214 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   803 KITANLDVFLRRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSN 867
            |.|.||:.:::.||.:.|...:|:|..|...:||.::..:|:.|..|....|.|:..|::.||:.
  Fly   445 KKTRNLESYVQWFNRLSYLTASEIVKYPKKKQRVRIIEYWIETARECFNIGNFNSLMAIIAGLNL 509

  Fly   868 MAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFV-----------GKLQPPLIPFMPL 921
            ..:.||::||.|:.|   ..|...|..:||:.|..:||..:           .:.:..:|||..|
  Fly   510 APIGRLKKTWAKVQS---AKFSVLEHQMDPTSNFNSYRSTLKAAMWRSEGATEERERIIIPFFSL 571

  Fly   922 LLKDMTFAHEGNKTSL-DGLVNFEKMHMMAQTMRTIRFCRSRSLGLE--PPSPKSEGEVRSYISS 983
            .:||:.|.:||....| :..:||||...:|:.:......:..:...|  |       .|.:|:.:
  Fly   572 FVKDLYFLNEGCSNRLPNNHINFEKCSQLAKQVMEFNEWKKVNCPFERLP-------NVIAYLQN 629

  Fly   984 FRVIDNQRVLTAMSQKVEP 1002
            ..|: |:..|:..|.:.||
  Fly   630 SAVL-NENTLSMASFECEP 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Epac	NP_001097202.2	Crp	28..>146	CDD:223736
		CAP_ED	36..146	CDD:237999
		DEP_Epac	199..330	CDD:239884
		CAP_ED	352..463	CDD:237999
		Crp	373..525	CDD:223736
		RasGEF_N	489..594	CDD:279012
		UBQ	665..>714	CDD:294102
		RasGEF	766..1002	CDD:214539	56/212 (26%)
CG7369	NP_649415.2	RasGEF_N	116..261	CDD:279012
CG7369	NP_649415.2	RasGEF	388..649	CDD:214539	58/214 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467902
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940