DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Epac and Rapgefl1

DIOPT Version :9

Sequence 1:	NP_001097202.2	Gene:	Epac / 35588	FlyBaseID:	FBgn0085421	Length:	1006	Species:	Drosophila melanogaster
Sequence 2:	NP_001074394.1	Gene:	Rapgefl1 / 268480	MGIID:	3611446	Length:	662	Species:	Mus musculus

Alignment Length:	543	Identity:	196/543 - (36%)
Similarity:	298/543 - (54%)	Gaps:	64/543 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   493 GTPAKMLEHLLETRLGQSVGG-------MDPFLDDFLLTHIVFMPVVQLVDELANYFHCDAHEDA 550
            |.|.:. ||||...|.:..||       .|..|||.:|||.:|:|..:.:.||..||  ....:.
Mouse   146 GAPERP-EHLLNRVLERLAGGTTRDSSASDILLDDIVLTHSLFLPTEKFLQELHQYF--VQSRNV 207

  Fly   551 QTPEDREYIINFKKRVIQFMQKWVMAVRHAAFEEPSVCDFIEDLAAEVEAD----PDLNEETSIV 611
            :.||.    :..|:..:..:..::...:....||......|::|...:..|    .||.|:|..:
Mouse   208 EGPEG----LGRKQACLALLLHFLDTYQGLLQEEEGAGHIIKELYLLIMKDESLYQDLREDTLRL 268

  Fly   612 HNVLTQMARYQEDRNQNAGQKWKLPPNGQPICLFSGNATPSKTV-------------------IR 657
            |.::..:             :.|:|...||         |||.|                   .|
Mouse   269 HQLVETV-------------ELKIPEESQP---------PSKQVKPLFRHFRRIDSCLQTRVAFR 311

  Fly   658 PDDDIIFRVYCADHTYCTLRFPMHTTAELIKACAADKLQLNRGP---ED-LVLVEVKSNGERSVF 718
            ..|:|..|||..||:|.|:|..:..:.:.|.....:|||.:..|   || |:||.|.|:||:.:.
Mouse   312 GSDEIFCRVYMPDHSYVTIRSRLSASVQDILGSVTEKLQYSEEPAEREDALILVAVASSGEKVLL 376

  Fly   719 KDNDVSIPTGLSLNGRLFVSVKDHLDALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLF 783
            :..:..:.|.|.:|..||...:|..:||..|.|:...:.| |.::..:..:::|.|:|.|.|:||
Mouse   377 QPTEDCVFTTLGINSHLFACTRDSYEALVPLPEEVQVSPG-DTEIHRVEPEDVANHLTAFHWELF 440

  Fly   784 WAVHEYELLYHTFGRHHFGKITANLDVFLRRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAY 848
            ..|||.|.:.:.|......:.||||::.|:|.:||.:|:.||::...:..|||.|::||||:||.
Mouse   441 RCVHELEFVDYVFHGERGRRETANLELLLQRCSEVTHWVATEVLLCEAPGKRVQLLKKFIKIAAI 505

  Fly   849 CKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFVGKLQP 913
            ||:.|:|.:|:||||||.|.|||||:.||||:|.||:.:|::||.|.||.|||::||..:.|::|
Mouse   506 CKQNQDLLSFYAVVMGLDNAAVSRLRLTWEKLPGKFKNLFRKFEGLTDPCRNHKSYREVISKMKP 570

  Fly   914 PLIPFMPLLLKDMTFAHEGNKTSLDGLVNFEKMHMMAQTMRTIRFCRSRSLGLEPPSPKSEGEVR 978
            |||||:||:|||:||.|||:||.:|||||.||:|.:|:.:||||..|||.|.|:..:.....:.:
Mouse   571 PLIPFVPLILKDLTFLHEGSKTLVDGLVNIEKLHSVAEKVRTIRKYRSRPLCLDMEASPHHLQTK 635

  Fly   979 SYISSFRVIDNQRVLTAMSQKVE 1001
            :|:..|:|||||..|..:|.|:|
Mouse   636 AYVRQFQVIDNQNHLFELSYKLE 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Epac	NP_001097202.2	Crp	28..>146	CDD:223736
		CAP_ED	36..146	CDD:237999
		DEP_Epac	199..330	CDD:239884
		CAP_ED	352..463	CDD:237999
		Crp	373..525	CDD:223736	14/38 (37%)
		RasGEF_N	489..594	CDD:279012	28/107 (26%)
		UBQ	665..>714	CDD:294102	20/52 (38%)
		RasGEF	766..1002	CDD:214539	116/236 (49%)
Rapgefl1	NP_001074394.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..149		1/2 (50%)
Rapgefl1	NP_001074394.1	RasGEF	420..658	CDD:214539	115/237 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143470at2759
OrthoFinder	1	1.000	-	-		FOG0000899
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920