Protein Alignment Epac and RGL4

DIOPT Version :10

• Sequence 1: NP_001097202.2
• Gene: Epac / 35588
• FlyBaseID: FBgn0085421
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: NP_001316353.1
• Gene: RGL4 / 266747
• HGNCID: 31911
• Length: 580
• Species: Homo sapiens
• Alignment Length: 311
• Identity: 63/311 - (20%)
• Similarity: 112/311 - (36%)
• Gaps: 67/311 - (21%)

  Fly   751 EQECPTEG-------VDI-DLEILSTKELAYHITLFEWDLFWAVHEYELLYHTFGRHHF---GKI 804
            |..||..|       .:: |:.....:.||..:||.:.:||..|..:|.|...:|:.|.   ..:
Human   195 ESSCPCRGSVKNQPSEELPDMTTFPPRLLAEQLTLMDAELFKKVVLHECLGCIWGQGHLKGNEHM 259

  Fly   805 TANLDVFLRRFNEVQYWIVTELVSTPSL--SKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSN 867
            ...:...:..||.:...|.|..:...|:  ..|..:|..:||:|..|....|.::...:|..|.:
Human   260 APTVRATIAHFNRLTNCITTSCLGDHSMRARDRARVVEHWIKVARECLSLNNFSSVHVIVSALCS 324

  Fly   868 MAVSRLQQTWEKIPSKFRKIFQEF---------EALI--------DPSRNHRAYRVFVGKLQPPL 915
            ..:.:|.:||..:.||..|..:|.         :.||        ...||.:..::.:.:.:..:
Human   325 NPIGQLHKTWAGVSSKSMKELKELCKKDTAVKRDLLIKAGSFKVATQERNPQRVQMRLRRQKKGV 389

  Fly   916 IPFMPLLLKDMTFAHEGNKTSLDGLVN--------FEKMHMMAQTMRTIR----------FCRSR 962
            :||:...|.::..........|||..|        .::|.::.......|          |.|..
Human   390 VPFLGDFLTELQRLDSAIPDDLDGNTNKRSKEVRVLQEMQLLQVAAMNYRLRPLEKFVTYFTRME 454

  Fly   963 SLGLEPPSPKSEGEVRSYISSFRVIDNQ-----------RVLTAMSQKVEP 1002
            .|        |:.|...:....|::.|.           :|||...|.|.|
Human   455 QL--------SDKERWGFTMMSRIVSNSWPQAIHPPQPPKVLTLQLQAVLP 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Epac	NP_001097202.2	CAP_ED	36..146	CDD:237999
		DEP_Epac	199..330	CDD:239884
		CAP_ED	352..463	CDD:237999
		RasGEF_N	489..594	CDD:459873
		Ubl1_cv_Nsp3_N-like	652..>722	CDD:475130
		RasGEF	766..1002	CDD:214539	57/286 (20%)
RGL4	NP_001316353.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	117..215		4/19 (21%)
		RasGEF	216..451	CDD:238087	45/234 (19%)