DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Epac and Gm4871

DIOPT Version :9

Sequence 1:	NP_001097202.2	Gene:	Epac / 35588	FlyBaseID:	FBgn0085421	Length:	1006	Species:	Drosophila melanogaster
Sequence 2:	NP_001094933.1	Gene:	Gm4871 / 231885	MGIID:	3648713	Length:	314	Species:	Mus musculus

Alignment Length:	305	Identity:	63/305 - (20%)
Similarity:	98/305 - (32%)	Gaps:	104/305 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   336 TSEELELVFEELVHIAALSHLSTSIKRELSSIFVFEAHAQAGTILFNQGDEGRSWYILLKGSVDV 400
            |....|.|.:.:.:|.|..|....:.   .|:|:...|....|           |.:|     |:
Mouse    56 TYNSFEFVEQMIAYIPAAVHYHDQLS---ISLFLAVYHRYCST-----------WEVL-----DL 101

  Fly   401 VIHGKGTVATLKTGDDFGKLALIN--------------DAPRAATIVLKENNCHLLRVDKEHFNR 451
            ::....:.......|...|.|:.|              |:|..|  |:::    |:.....|...
Mouse   102 LMKTYPSFQPDCEQDQLTKSAIFNFLAHWLDTFPEHFFDSPNLA--VMRQ----LMDYAGRHMPS 160

  Fly   452 ILRDVEANTL--RLQEHGKDVLVLERVAKQRGQHSAFKYTVMSGTPAKMLEHLLETRL---GQSV 511
            ...|.|:..|  ||:|.....|.||:......:..|          ::|.|: |..||   .:..
Mouse   161 AEFDKESRELLSRLEEQEAKKLKLEKDCAATAEQDA----------SRMQEN-LALRLASVAEPQ 214

  Fly   512 GGMDPFLDDFLLTHIVFMPV------VQL--VDE---LANYFHCDAHEDAQTPEDREYIINFKKR 565
            |.:.|.:|..||...|..|.      |||  .|:   .:.|        .|:|||
Mouse   215 GDLQPQVDTELLEQSVVEPFVPEPGPVQLPTFDQALPTSTY--------TQSPED---------- 261

  Fly   566 VIQFMQKWVMAVRHAAFEEPSVCDFIEDLAAEVEADPDLNEETSI 610
                     :||..||           |:.|:..||...:|...:
Mouse   262 ---------VAVDEAA-----------DMVADETADEATHEAVDV 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Epac	NP_001097202.2	Crp	28..>146	CDD:223736
		CAP_ED	36..146	CDD:237999
		DEP_Epac	199..330	CDD:239884
		CAP_ED	352..463	CDD:237999	22/126 (17%)
		Crp	373..525	CDD:223736	35/170 (21%)
		RasGEF_N	489..594	CDD:279012	25/118 (21%)
		UBQ	665..>714	CDD:294102
		RasGEF	766..1002	CDD:214539
Gm4871	NP_001094933.1	REM	63..176	CDD:100121	26/137 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900