DRSC/TRiP Functional Genomics Resources

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Protein Alignment Epac and RGL1

DIOPT Version :9

Sequence 1:NP_001097202.2 Gene:Epac / 35588 FlyBaseID:FBgn0085421 Length:1006 Species:Drosophila melanogaster
Sequence 2:NP_055964.3 Gene:RGL1 / 23179 HGNCID:30281 Length:803 Species:Homo sapiens


Alignment Length:649 Identity:114/649 - (17%)
Similarity:221/649 - (34%) Gaps:220/649 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   436 ENNCHLLRVDKEHFNRILRDVEANTLRLQEHGKDV-------LVLERVAKQRGQ----------- 482
            |:..|.|..|......:|:..|::   :|:.|::|       :.|:||..|:..           
Human    23 ESTGHWLVEDHVRIWEVLKTEESS---IQDWGEEVEEGAVYHVTLKRVQIQQAANKGARWLGVEG 84

  Fly   483 ------HSAFKY------TVMSGTPAKMLEHLLETRLGQSVGGMD-PFLDDFLLTHIVFMPVVQL 534
                  |:..:|      |:.:||..|::|:||     .:.|..| .::..||.|:..|      
Human    85 DQLPPGHTVSQYETCKIRTIKAGTLEKLVENLL-----TAFGDNDFTYISIFLSTYRGF------ 138

  Fly   535 VDELANYFHCDAHEDAQTPEDREYIINFKKRVIQFMQKWVMAVRHAAFEEPSVCDFIEDLAAEVE 599
                           |.|.|..|.:::                |:.....|:         .|.:
Human   139 ---------------ASTKEVLELLLD----------------RYGNLTSPN---------CEED 163

  Fly   600 ADPDLNEETSIVHNVLTQMARYQEDRNQNAGQKWKLPPNGQPICLFSGNATPSKTVIRPDDDIIF 664
            .....:|...::.|.:..:.|...|:   ..:.::.||                           
Human   164 GSQSSSESKMVIRNAIASILRAWLDQ---CAEDFREPP--------------------------- 198

  Fly   665 RVYCADHTYCTLRFPMHTTAELIKACAADKLQLNRGPEDLVLVEVKSNGERSVFKDNDVSIPTGL 729
                  |..|..:...:.|          ::.....||......::...::.|..||  .:|..:
Human   199 ------HFPCLQKLLDYLT----------RMMPGSDPERRAQNLLEQFQKQEVETDN--GLPNTI 245

  Fly   730 SLNGRLFVSVKDHLDALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHEYELLYH 794
            |.:                |:|:|....|...:....|...:|..:|..:..||..|    :.:|
Human   246 SFS----------------LEEEEELEGGESAEFTCFSEDLVAEQLTYMDAQLFKKV----VPHH 290

  Fly   795 TFG-----------RHHFGKITANLDVFLRRFNEVQYWIVTELVSTPSL--SKRVGLVRKFIKLA 846
            ..|           :|....|.|.:.    :||.:...:|:.::....|  .:|..::.|:|.:|
Human   291 CLGCIWSRRDKKENKHLAPTIRATIS----QFNTLTKCVVSTILGGKELKTQQRAKIIEKWINIA 351

  Fly   847 AYCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFVGK- 910
            ..|:..:|.::..|:|..|.:.::.||::||..:|.....:|:|...:.....||...|..:.| 
Human   352 HECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVPRDRMLMFEELSDIFSDHNNHLTSRELLMKE 416

  Fly   911 ------------------------LQPPL------IPFMPLLLKDMTFAHEGNKTSLD-GLVNFE 944
                                    ||..:      :|::...|.|:|......:..:: ||:|||
Human   417 GTSKFANLDSSVKENQKRTQRRLQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIEGGLINFE 481

  Fly   945 KMHMMAQTMRTIRFCRS--RSLGLEPPSPKSEGEVRSYISSFRVIDNQRVLT-----AMSQKVE 1001
            |.....:.:..|:..:|  .|..:.|.        :.:|..|:   .|::||     |:|.::|
Human   482 KRRREFEVIAQIKLLQSACNSYCMTPD--------QKFIQWFQ---RQQLLTEEESYALSCEIE 534

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EpacNP_001097202.2 Crp 28..>146 CDD:223736
CAP_ED 36..146 CDD:237999
DEP_Epac 199..330 CDD:239884
CAP_ED 352..463 CDD:237999 6/26 (23%)
Crp 373..525 CDD:223736 26/119 (22%)
RasGEF_N 489..594 CDD:279012 19/105 (18%)
UBQ 665..>714 CDD:294102 5/48 (10%)
RasGEF 766..1002 CDD:214539 59/288 (20%)
RGL1NP_055964.3 RasGEFN 100..231 CDD:214571 31/227 (14%)
RasGEF 263..532 CDD:238087 58/287 (20%)
RalGDS_RA 683..768 CDD:176351
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3629
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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