Protein Alignment Epac and Rapgef3

DIOPT Version :10

• Sequence 1: NP_001097202.2
• Gene: Epac / 35588
• FlyBaseID: FBgn0085421
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: XP_036015267.1
• Gene: Rapgef3 / 223864
• MGIID: 2441741
• Length: 963
• Species: Mus musculus
• Alignment Length: 1016
• Identity: 397/1016 - (39%)
• Similarity: 558/1016 - (54%)
• Gaps: 124/1016 - (12%)

  Fly    52 EDLEKGVTLFRAGEQGRFWYAVLGGSLEVRY--HAHADADGKSAVTLCNLGVGATFGESVLHDLP 114
            ||.:.||.:.|:...|| |.:....:.:|.:  ..|... |.:.|....:|.....|   |.|:.
Mouse     7 EDAKPGVVVGRSSSSGR-WLSSFLPTSQVSWPGENHWQV-GPAVVESPAVGAPQVGG---LPDVV 66

  Fly   115 RDSTVVTKTTCELLRVEQQDFRLIWEKNKELMNDIFTNCKLKNGFGPSVQATAAATSPTKRPLSP 179
            .:.|::......:.|.....::|::|..:                 ||.......|..|.   |.
Mouse    67 PEGTLLNMVLKRMHRPRCCSYQLVFEHRR-----------------PSCIQGLRWTPLTN---SE 111

  Fly   180 DHPNPALPITETPSPAMNRMGWALRTLLVADNSSCLKDRKVSGKLIRKCAPGTELVDWLVNLSPI 244
            |..:..:.:.:..:..:::.|..|...|:|...:.::|||...:|.|.|..|.||||.::.|...
Mouse   112 DSLDFRVSLEQATTEHVHKAGKLLHRHLLATYPTLIRDRKYHLRLYRHCCSGRELVDGILALGLG 176

  Fly   245 VHTRAQAAGMWQALLEEGVLAH---VNKEQPFKDK-CFLYRFRIDEEGGTAAAGVPQAEDLGA-- 303
            ||:|:||.|:.|.||:||.|.|   |..:..|:|: ...|||          .| |:.|..|.
Mouse   177 VHSRSQAVGICQVLLDEGALCHGSPVKHDWTFQDRDAQFYRF----------PG-PEPEPTGTQD 230

  Fly   304 ANEHIREALSALFQRGPDATLRMILRKPSHERTSEELELVFEELVHIAALSHLSTSIKRELSSIF 368
            ..|.:.||::.|.||||||.|.:.||||..:||.|||:|:||||:||.|::|||.|:||||:::.
Mouse   231 VEEELVEAMALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVL 295

  Fly   369 VFEAHAQAGTILFNQGDEGRSWYILLKGSVDVVIHGKGTVATLKTGDDFGKLALINDAPRAATIV 433
            :||.|::|||:||:|||:|.||||:.||||:||.||||.|.||..|||||:|||:|||||||||:
Mouse   296 LFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATII 360

  Fly   434 LKENNCHLLRVDKEHFNRILRDVEANTLRLQEHGKDVLVLERVAKQRGQH-----SAFKYTVMSG 493
            |:|||||.|||||:.||||::||||.|:||:||||.||||||.::..|..     ...:||||||
Mouse   361 LRENNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERTSQGAGPSRPPTPGRNRYTVMSG 425

  Fly   494 TPAKMLEHLLETRLGQSVGGMDP---FLDDFLLTHIVFMPVVQLVDELANYFHCDAHEDA--QTP 553
            ||.|:||.|||.....| ...||   ||.||||||.||||..||...|.::||.:..:.|  ...
Mouse   426 TPEKILELLLEAMRPDS-SAHDPTETFLSDFLLTHSVFMPSTQLFTALLHHFHVEPADPAGGSEQ 489

  Fly   554 EDREYIINFKKRVIQFMQKWVMAVRHAAFEEPSVCDFIEDLAAEVEADPDLNEETSIVHNVLTQM 618
            |...||.|.::::::.:.:||.........:|....|::.|:..|..|..|:       |:|.:
Mouse   490 EHSTYICNKRQQILRLVGRWVALYSPMLHSDPVATSFLQKLSDLVSRDARLS-------NLLRE- 546

  Fly   619 ARYQEDRNQ--------NAGQKWK-------LPPNGQPICLFSGNATPSKT-VIRPDDDIIFRVY 667
             :|.|.|..        |...:.|       ||...:|:        ||.. .||..|.:.:.:.
Mouse   547 -QYPERRRHHRLENGCGNVSPQTKARNAPVWLPNQEEPL--------PSSAGAIRVGDKVPYDIC 602

  Fly   668 CADHTYCTLRFPMHTTAELIKACAADKLQLNRGPEDLVLVEVKSNGERSVFKDNDVSIPTGLSLN 732
            ..||:..||..|:..:...:.|..|.:....:|.   |||:|.|.|:....:.:...:.|.|.||
Mouse   603 RPDHSVLTLHLPVTASVREVMAALAHEDHWTKGQ---VLVKVNSAGDVVGLQPDARGVATSLGLN 664

  Fly   733 GRLFVSVKDHLDALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVH---EYELLYH 794
            .||||.....:..||...||..||.|....|:::|.|:||..:|..:|:||..:|   |.||:::
Mouse   665 ERLFVVDPQEVHELTPHPEQLGPTLGSSEMLDLVSAKDLAGQLTDHDWNLFNRIHQVQEVELIHY 729

  Fly   795 TFGRHHFGKI-TANLDVFLRRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAF 858
            ..|..|...: ||||:.|:|||||:|||:.|||...|....|..|:||||||||:.||.:|||:|
Mouse   730 VLGPQHLRDVTTANLERFMRRFNELQYWVATELCLCPVPGSRAQLLRKFIKLAAHLKEQKNLNSF 794

  Fly   859 FAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFVGKLQPPLIPFMPLLL 923
            |||:.||||.|:|||..|||::|.|.||::...|.|:|||.|||.||:.:.||.||:||||||||
Mouse   795 FAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALTKLSPPVIPFMPLLL 859

  Fly   924 KDMTFAHEGNKTSLDGLVNFEKMHMMAQTMRTIRFCRSRSLGLEPPSP----------------- 971
            ||:||.||||.|.::.|:|||||.|||:.:|.:..|||.|..  |.||
Mouse   860 KDVTFIHEGNHTLVENLINFEKMRMMARAVRMLHHCRSHSTA--PLSPLRSRVSHIHEDSQGSRI 922

  Fly   972 ----------KSEGEVRSYISSFRVIDNQRVLTAMSQKVEP 1002
                      :|.....:|:...:||||||.|:.:|:::||
Mouse   923 STCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP 963

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Epac	NP_001097202.2	CAP_ED	36..146	CDD:237999	20/95 (21%)
		DEP_Epac	199..330	CDD:239884	51/136 (38%)
		CAP_ED	352..463	CDD:237999	75/110 (68%)
		RasGEF_N	489..594	CDD:459873	42/109 (39%)
		Ubl1_cv_Nsp3_N-like	652..>722	CDD:475130	18/70 (26%)
		RasGEF	766..1002	CDD:214539	123/266 (46%)
Rapgef3	XP_036015267.1	DEP_Epac	131..257	CDD:239884	51/136 (38%)
		CAP_ED	281..390	CDD:237999	74/108 (69%)
		REM	426..547	CDD:100121	43/130 (33%)
		RasGEF	695..963	CDD:214539	124/269 (46%)