DRSC/TRiP Functional Genomics Resources

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Protein Alignment Epac and Rapgef3

DIOPT Version :9

Sequence 1:NP_001097202.2 Gene:Epac / 35588 FlyBaseID:FBgn0085421 Length:1006 Species:Drosophila melanogaster
Sequence 2:XP_036015267.1 Gene:Rapgef3 / 223864 MGIID:2441741 Length:963 Species:Mus musculus


Alignment Length:1016 Identity:397/1016 - (39%)
Similarity:558/1016 - (54%) Gaps:124/1016 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 EDLEKGVTLFRAGEQGRFWYAVLGGSLEVRY--HAHADADGKSAVTLCNLGVGATFGESVLHDLP 114
            ||.:.||.:.|:...|| |.:....:.:|.:  ..|... |.:.|....:|.....|   |.|:.
Mouse     7 EDAKPGVVVGRSSSSGR-WLSSFLPTSQVSWPGENHWQV-GPAVVESPAVGAPQVGG---LPDVV 66

  Fly   115 RDSTVVTKTTCELLRVEQQDFRLIWEKNKELMNDIFTNCKLKNGFGPSVQATAAATSPTKRPLSP 179
            .:.|::......:.|.....::|::|..:                 ||.......|..|.   |.
Mouse    67 PEGTLLNMVLKRMHRPRCCSYQLVFEHRR-----------------PSCIQGLRWTPLTN---SE 111

  Fly   180 DHPNPALPITETPSPAMNRMGWALRTLLVADNSSCLKDRKVSGKLIRKCAPGTELVDWLVNLSPI 244
            |..:..:.:.:..:..:::.|..|...|:|...:.::|||...:|.|.|..|.||||.::.|...
Mouse   112 DSLDFRVSLEQATTEHVHKAGKLLHRHLLATYPTLIRDRKYHLRLYRHCCSGRELVDGILALGLG 176

  Fly   245 VHTRAQAAGMWQALLEEGVLAH---VNKEQPFKDK-CFLYRFRIDEEGGTAAAGVPQAEDLGA-- 303
            ||:|:||.|:.|.||:||.|.|   |..:..|:|: ...|||          .| |:.|..|.  
Mouse   177 VHSRSQAVGICQVLLDEGALCHGSPVKHDWTFQDRDAQFYRF----------PG-PEPEPTGTQD 230

  Fly   304 ANEHIREALSALFQRGPDATLRMILRKPSHERTSEELELVFEELVHIAALSHLSTSIKRELSSIF 368
            ..|.:.||::.|.||||||.|.:.||||..:||.|||:|:||||:||.|::|||.|:||||:::.
Mouse   231 VEEELVEAMALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVL 295

  Fly   369 VFEAHAQAGTILFNQGDEGRSWYILLKGSVDVVIHGKGTVATLKTGDDFGKLALINDAPRAATIV 433
            :||.|::|||:||:|||:|.||||:.||||:||.||||.|.||..|||||:|||:|||||||||:
Mouse   296 LFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATII 360

  Fly   434 LKENNCHLLRVDKEHFNRILRDVEANTLRLQEHGKDVLVLERVAKQRGQH-----SAFKYTVMSG 493
            |:|||||.|||||:.||||::||||.|:||:||||.||||||.::..|..     ...:||||||
Mouse   361 LRENNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERTSQGAGPSRPPTPGRNRYTVMSG 425

  Fly   494 TPAKMLEHLLETRLGQSVGGMDP---FLDDFLLTHIVFMPVVQLVDELANYFHCDAHEDA--QTP 553
            ||.|:||.|||.....| ...||   ||.||||||.||||..||...|.::||.:..:.|  ...
Mouse   426 TPEKILELLLEAMRPDS-SAHDPTETFLSDFLLTHSVFMPSTQLFTALLHHFHVEPADPAGGSEQ 489

  Fly   554 EDREYIINFKKRVIQFMQKWVMAVRHAAFEEPSVCDFIEDLAAEVEADPDLNEETSIVHNVLTQM 618
            |...||.|.::::::.:.:||.........:|....|::.|:..|..|..|:       |:|.: 
Mouse   490 EHSTYICNKRQQILRLVGRWVALYSPMLHSDPVATSFLQKLSDLVSRDARLS-------NLLRE- 546

  Fly   619 ARYQEDRNQ--------NAGQKWK-------LPPNGQPICLFSGNATPSKT-VIRPDDDIIFRVY 667
             :|.|.|..        |...:.|       ||...:|:        ||.. .||..|.:.:.:.
Mouse   547 -QYPERRRHHRLENGCGNVSPQTKARNAPVWLPNQEEPL--------PSSAGAIRVGDKVPYDIC 602

  Fly   668 CADHTYCTLRFPMHTTAELIKACAADKLQLNRGPEDLVLVEVKSNGERSVFKDNDVSIPTGLSLN 732
            ..||:..||..|:..:...:.|..|.:....:|.   |||:|.|.|:....:.:...:.|.|.||
Mouse   603 RPDHSVLTLHLPVTASVREVMAALAHEDHWTKGQ---VLVKVNSAGDVVGLQPDARGVATSLGLN 664

  Fly   733 GRLFVSVKDHLDALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVH---EYELLYH 794
            .||||.....:..||...||..||.|....|:::|.|:||..:|..:|:||..:|   |.||:::
Mouse   665 ERLFVVDPQEVHELTPHPEQLGPTLGSSEMLDLVSAKDLAGQLTDHDWNLFNRIHQVQEVELIHY 729

  Fly   795 TFGRHHFGKI-TANLDVFLRRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAF 858
            ..|..|...: ||||:.|:|||||:|||:.|||...|....|..|:||||||||:.||.:|||:|
Mouse   730 VLGPQHLRDVTTANLERFMRRFNELQYWVATELCLCPVPGSRAQLLRKFIKLAAHLKEQKNLNSF 794

  Fly   859 FAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFVGKLQPPLIPFMPLLL 923
            |||:.||||.|:|||..|||::|.|.||::...|.|:|||.|||.||:.:.||.||:||||||||
Mouse   795 FAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALTKLSPPVIPFMPLLL 859

  Fly   924 KDMTFAHEGNKTSLDGLVNFEKMHMMAQTMRTIRFCRSRSLGLEPPSP----------------- 971
            ||:||.||||.|.::.|:|||||.|||:.:|.:..|||.|..  |.||                 
Mouse   860 KDVTFIHEGNHTLVENLINFEKMRMMARAVRMLHHCRSHSTA--PLSPLRSRVSHIHEDSQGSRI 922

  Fly   972 ----------KSEGEVRSYISSFRVIDNQRVLTAMSQKVEP 1002
                      :|.....:|:...:||||||.|:.:|:::||
Mouse   923 STCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP 963

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EpacNP_001097202.2 Crp 28..>146 CDD:223736 20/95 (21%)
CAP_ED 36..146 CDD:237999 20/95 (21%)
DEP_Epac 199..330 CDD:239884 51/136 (38%)
CAP_ED 352..463 CDD:237999 75/110 (68%)
Crp 373..525 CDD:223736 100/159 (63%)
RasGEF_N 489..594 CDD:279012 42/109 (39%)
UBQ 665..>714 CDD:294102 13/48 (27%)
RasGEF 766..1002 CDD:214539 123/266 (46%)
Rapgef3XP_036015267.1 DEP_Epac 131..257 CDD:239884 51/136 (38%)
CAP_ED 281..390 CDD:237999 74/108 (69%)
RasGEF_N 421..530 CDD:395493 42/109 (39%)
RasGEF 695..963 CDD:214539 124/269 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 136 1.000 Domainoid score I4904
eggNOG 1 0.900 - - E1_KOG3629
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49338
OrthoDB 1 1.010 - - D143470at2759
OrthoFinder 1 1.000 - - FOG0000899
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_103967
Panther 1 1.100 - - LDO PTHR23113
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R9235
SonicParanoid 1 1.000 - - X1712
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1312.820

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