Protein Alignment Epac and RASGEF1A

DIOPT Version :9

• Sequence 1: NP_001097202.2
• Gene: Epac / 35588
• FlyBaseID: FBgn0085421
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: NP_001269791.1
• Gene: RASGEF1A / 221002
• HGNCID: 24246
• Length: 489
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 111/536 - (20%)
• Similarity: 205/536 - (38%)
• Gaps: 142/536 - (26%)

  Fly   490 VMSGTPAKMLEHLLETRLGQSVGGMDPFLD-----DFLLTHIVFMPVVQLVDELANYFHC-DAHE 548
            ::||:...::|||:.|        :|.:.|     .|||:..||||...|:..:...  | :..:
Human    53 LISGSLEALMEHLVPT--------VDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQI--CVEQKQ 107

  Fly   549 DAQTPEDREYIINFKKRVIQFMQKWVMAVRHAAFEEPSVCDFIEDLA-AEVEADPDLNEETSIVH 612
            ..:...::..:.:|..:::|.:::|..|..:         ||.::.| ||::|         |.|
Human   108 QLEAGPEKAKLKSFSAKIVQLLKEWTEAFPY---------DFQDEKAMAELKA---------ITH 154

  Fly   613 NVLTQMARYQEDRNQNAGQKWKLPPNGQPICLFSGNATPSKTVIRPDDDIIFRVYCADHTYCTLR 677
            .| ||.   .|:                       |.|..|.:.:....::..:        ..|
Human   155 RV-TQC---DEE-----------------------NGTVKKAIAQMTQSLLLSL--------AAR 184

  Fly   678 FPMHTTAELIKACAADKLQLNRGPEDLVLVEVKSNGERSVFKDNDVSIPTGLSLNGRLFVSVKDH 742
            ..:....|.::..|.||     ||    :::.|....:                        ||.
Human   185 SQLQELREKLRPPAVDK-----GP----ILKTKPPAAQ------------------------KDI 216

  Fly   743 L----DALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHEYELLYHTFGRHHFGK 803
            |    |.|...|:.      ..|:|:.:|        :::..||...|...:.|.:...|....|
Human   217 LGVCCDPLVLAQQL------THIELDRVS--------SIYPEDLMQIVSHMDSLDNHRCRGDLTK 267

  Fly   804 ITANLDVFLRRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNM 868
             |.:|:.:...||.:...:.||:........|..::..||.:|..|....|.|:..|::.|::..
Human   268 -TYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFIDVARECFNIGNFNSMMAIISGMNLS 331

  Fly   869 AVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFV-GKLQPP----------LIPFMPLL 922
            .|:||::||.|:  |..| |...|..:|||.|...||..: |..|..          :||...|.
Human   332 PVARLKKTWSKV--KTAK-FDVLEHHMDPSSNFCNYRTALQGATQRSQMANSSREKIVIPVFNLF 393

  Fly   923 LKDMTFAHEGNKTSL-DGLVNFEKMHMMAQTMRTIRFCRSRSLGLEPPSPKSEGEVRSYISSFRV 986
            :||:.|.|:.:...| :|.:||:|...:::.:........    :|.|..|.: :::||:.:..:
Human   394 VKDIYFLHKIHTNHLPNGHINFKKFWEISRQIHEFMTWTQ----VECPFEKDK-KIQSYLLTAPI 453

  Fly   987 IDNQRVLTAMSQKVEP 1002
            ...:.:..|..:...|
Human   454 YSEEALFVASFESEGP 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Epac	NP_001097202.2	Crp	28..>146	CDD:223736
		CAP_ED	36..146	CDD:237999
		DEP_Epac	199..330	CDD:239884
		CAP_ED	352..463	CDD:237999
		Crp	373..525	CDD:223736	11/39 (28%)
		RasGEF_N	489..594	CDD:279012	23/109 (21%)
		UBQ	665..>714	CDD:294102	8/48 (17%)
		RasGEF	766..1002	CDD:214539	58/247 (23%)
RASGEF1A	NP_001269791.1	REM	57..184	CDD:100121	34/189 (18%)
		RasGEF	222..470	CDD:214539	64/271 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910