Protein Alignment Epac and Rgl1

DIOPT Version :10

• Sequence 1: NP_001097202.2
• Gene: Epac / 35588
• FlyBaseID: FBgn0085421
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: NP_001333046.1
• Gene: Rgl1 / 19731
• MGIID: 107484
• Length: 803
• Species: Mus musculus
• Alignment Length: 658
• Identity: 121/658 - (18%)
• Similarity: 223/658 - (33%)
• Gaps: 238/658 - (36%)

  Fly   436 ENNCHLLRVDKEHFNRILRDVEANTLRLQEHGKDV-------LVLERVAKQRGQ----------- 482
            ||..|.|..|......:|:..|::   :|:.|::|       :.|:||..|:..
Mouse    23 ENTGHWLVDDHARIWEVLKTEESS---IQDWGEEVEEGAVYHVTLKRVQIQQAANKGARWLGVEG 84

  Fly   483 ------HSAFKY------TVMSGTPAKMLEHLLETRLGQSVGGMD-PFLDDFLLTHIVFMPVVQL 534
                  |:..:|      |:.:||..|::|:||     .:.|..| .::..||.|:..|....::
Mouse    85 DQLPPGHTVSQYETCKIRTIKAGTLEKLVENLL-----TAFGDNDFTYISIFLSTYRGFASTKEV 144

  Fly   535 VDELANYF------HCDAHEDAQTPEDREYIINFKKRVIQFMQKWVMAVRHAAFEEPSVCDFIED 593
            ::.|.:.:      :|:......:||.:..|.|   .:...::.|:                  |
Mouse   145 LELLLDRYGNLTGPNCEDDGSQSSPESKAVIRN---AIASILRAWL------------------D 188

  Fly   594 LAAEVEADPDLNEETSIVHNVLTQMARYQEDRNQNAGQKWKLPPNGQPICLFSGNATPSKTVIRP 658
            ..||     |..|                             ||:
Mouse   189 QCAE-----DFRE-----------------------------PPH-------------------- 199

  Fly   659 DDDIIFRVYCADHTYCTLRFP-MHTTAELIKACAADKLQLNRGPEDLVLVEVKSNGERSVFKDND 722
                               || :....|.:|       |:..|.:.    |.::......|:..|
Mouse   200 -------------------FPCLQKLLEYLK-------QMMPGSDP----ERRAQNLLEQFQKQD 234

  Fly   723 VSIPTGLSLNGRLFVSVKDHLDALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVH 787
            |....|| ||...|           .|:|:|....|...:....|...:|..:|..:..||..|
Mouse   235 VDSDNGL-LNTSSF-----------SLEEEEELESGGSAEFTNFSEDLVAEQLTYMDAQLFKKV- 286

  Fly   788 EYELLYHTFG-----------RHHFGKITANLDVFLRRFNEVQYWIVTELVSTPSL--SKRVGLV 839
               :.:|..|           :|....|.|.:.    :||.:...:|:.::.:..|  .:|..::
Mouse   287 ---VPHHCLGCIWSQRDKKENKHLAPTIRATIS----QFNTLTKCVVSTVLGSKELKTQQRARVI 344

  Fly   840 RKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAY 904
            .|:|.:|..|:..:|.::..|:|..|.:.::.||::.|..:|.....:|:|...:.....||...
Mouse   345 EKWINIAHECRILKNFSSLRAIVSALQSNSIYRLKKAWAAVPKDRMLMFEELSDIFSDHNNHLTS 409

  Fly   905 RVFVGK-------------------------LQPPL------IPFMPLLLKDMTFAHEGNKTSLD 938
            |..:.|                         ||..:      :|::...|.|:|......:..::
Mouse   410 RELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMGVMQGTVPYLGTFLTDLTMLDTALQDYIE 474

  Fly   939 -GLVNFEKMHMMAQTMRTIRF----CRSRSLGLEPPSPKSEGEVRSYISSFRVIDNQRVLT---- 994
             ||:||||.....:.:..|:.    |.|..:|   |..|       :|..|:   .|::|:
Mouse   475 GGLINFEKRRREFEVIAQIKLLQSACNSYCMG---PDQK-------FIQWFQ---RQQLLSEEES 526

  Fly   995 -AMSQKVE 1001
             |:|.::|
Mouse   527 YALSCEIE 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Epac	NP_001097202.2	CAP_ED	36..146	CDD:237999
		DEP_Epac	199..330	CDD:239884
		CAP_ED	352..463	CDD:237999	7/26 (27%)
		RasGEF_N	489..594	CDD:459873	20/111 (18%)
		Ubl1_cv_Nsp3_N-like	652..>722	CDD:475130	8/70 (11%)
		RasGEF	766..1002	CDD:214539	59/290 (20%)
Rgl1	NP_001333046.1	RasGEFN	100..231	CDD:214571	34/240 (14%)
		RasGEF	263..532	CDD:238087	58/289 (20%)
		RA_RGL	682..768	CDD:340730