Protein Alignment Epac and Rasgrp1

DIOPT Version :10

• Sequence 1: NP_001097202.2
• Gene: Epac / 35588
• FlyBaseID: FBgn0085421
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: NP_035376.1
• Gene: Rasgrp1 / 19419
• MGIID: 1314635
• Length: 795
• Species: Mus musculus
• Alignment Length: 398
• Identity: 87/398 - (21%)
• Similarity: 158/398 - (39%)
• Gaps: 73/398 - (18%)

  Fly   565 RVIQFMQKWVMAVRHAAFEEPSVCDFIEDLAAEVEADPDLNEETSIVHNVLTQ------------ 617
            ::.||  :.::::.|.| :..|:.|.|:......:||.:|.....::..:||.
Mouse    43 QITQF--RMMVSLGHLA-KGASLDDLIDSCIQSFDADGNLCRNNQLLQVMLTMHRIIISSAELLQ 104

  Fly   618 --MARYQEDRNQNAGQKWKLPPNGQPICLFSGNATPSKTVIRPDDDIIFRVYCADHTYCTLRFPM 680
              |..|::...:|:      |.....||.|          :|         |.....:...:...
Mouse   105 KVMNLYKDALEKNS------PGVCLKICYF----------VR---------YWITEFWIMFKMDA 144

  Fly   681 HTTAELIKACAADKLQLNRGPEDLVLVEVKSNGERSVFKDNDVSIPTGLSLNGRLFVSVKDHLDA 745
            ..|:.:      ::.|      ||    ||:|||.           |...|.....::.:|....
Mouse   145 SLTSTM------EEFQ------DL----VKANGEE-----------THCHLIDTTQINSRDWSRK 182

  Fly   746 LTQ-LQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHEYELLYHTFGRHHFGKITANLD 809
            ||| ::........|.:..:.|..:||:.|:|..|:..|..:...:  |..:..:...|....::
Mouse   183 LTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSD--YQNYLVNSCVKENPTME 245

  Fly   810 VFLRRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQ 874
            ..:...|.:..|:...::|.|:...|..:..|||.:|....:.||.|...||:.||.:.::|||:
Mouse   246 RSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLK 310

  Fly   875 QTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFVGKLQPPLIPFMPLLLKDMTFAHEGNKTSL-D 938
            :|...:|.:..|:..|...|:...||:..||...|:.....||.:.:.|||:...:|.....| |
Mouse   311 ETSSHVPHEINKVLGEMTELLSSCRNYDNYRRAYGECTHFKIPILGVHLKDLISLYEAMPDYLED 375

  Fly   939 GLVNFEKM 946
            |.||.:|:
Mouse   376 GKVNVQKL 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Epac	NP_001097202.2	CAP_ED	36..146	CDD:237999
		DEP_Epac	199..330	CDD:239884
		CAP_ED	352..463	CDD:237999
		RasGEF_N	489..594	CDD:459873	7/28 (25%)
		Ubl1_cv_Nsp3_N-like	652..>722	CDD:475130	11/69 (16%)
		RasGEF	766..1002	CDD:214539	50/182 (27%)
Rasgrp1	NP_035376.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37
		RasGEFN	54..176	CDD:214571	30/174 (17%)
		Ras exchanger motif region, required for transforming activity	57..110		10/53 (19%)
		RasGEF	201..437	CDD:214539	50/185 (27%)
		FRQ1	<471..527	CDD:444056
		C1_RASGRP1	540..594	CDD:410410
		Suppress the PT region-mediated translocation to plasma membrane	686..694
		PT region, mediates the BCR-dependent translocation to plasma membrane	717..795
		cc_RasGRP1_C	737..791	CDD:412086