DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Epac and Rapgef6

DIOPT Version :9

Sequence 1:NP_001097202.2 Gene:Epac / 35588 FlyBaseID:FBgn0085421 Length:1006 Species:Drosophila melanogaster
Sequence 2:XP_006532623.1 Gene:Rapgef6 / 192786 MGIID:2384761 Length:1614 Species:Mus musculus


Alignment Length:1267 Identity:276/1267 - (21%)
Similarity:483/1267 - (38%) Gaps:401/1267 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 AMDKRPCDRNLRDVELISCRLRRVEPLCRLPGSALQQLAMCGFYEDLEKGVTLFRAGEQGRFWYA 72
            |:.|:|.:|...|:.:|...|..:|.|..|....|:.::....||.......||.:....|.||.
Mouse    12 ALRKKPPERTPEDLNIIYSYLHGMEILSNLREHQLRLMSTRARYERYSGNQMLFCSETIARCWYI 76

  Fly    73 VLGGSLEVRYHAHADADGKSAVTLCNLGVGATFGESVLHDLPRDSTVVTKTTCELLRVEQQDFRL 137
            :|.||:.|          |.::.|.....|..||              .|..|:.|.:|..:. :
Mouse    77 LLSGSVLV----------KDSMVLPPCSFGKQFG--------------GKRGCDCLVLEPSEM-I 116

  Fly   138 IWEKNKELMNDIFTNCKLKNGFGPSVQATAAATSPTKRPLSPDHPN-----------------PA 185
            :.|.:|:..:.|             :|....|....:|....::..                 ||
Mouse   117 VVENSKDNEDSI-------------LQREIPARQSRRRFRKINYKGERQTIIDGVDINNYLSLPA 168

  Fly   186 ----LPITETPSPAMNRMGWALRTLLVADNSSCLKDRKVSGKLIRKCAPGTELVDWLVNLSPIVH 246
                :.:|:.|.|.:..:..:.....:|.:|                  |:.      :||.|..
Mouse   169 DLTKMHLTDNPHPQVTHVSSSQSGCSIASDS------------------GSS------SLSDIYQ 209

  Fly   247 -TRAQAAGMWQALLEEGVLAHVNKEQPFKDKCFLYRFRIDEEGGTAAAGVPQAEDLGAANEHIRE 310
             |.::...:....|.||.:...::|              :||.........|..||      :||
Mouse   210 ATESEVGDVDLTRLPEGPVDSEDEE--------------EEEEEIDRTDPLQGRDL------VRE 254

  Fly   311 ALSALFQRGPDATLRMILRKPSHERTSEELELVFEELVHIAALSHLSTSIKRELSSIFVFEAHAQ 375
            .|.               ::|: ::|.:::|.:.|.:..:.|.::::.|::|||.|:.|||...|
Mouse   255 CLE---------------KEPA-DKTDDDVEQLLEFMHQLPAFANMTMSVRRELCSVMVFEVVEQ 303

  Fly   376 AGTILFNQGDEGRSWYILLKGSVDVVIHGKGTVATLKTGDDFGKLALINDAPRAATIVLKENNCH 440
            ||.::...|.|..|||::|.|:|: :.|..|.:..|..|:.||.:..::.......:..|.::|.
Mouse   304 AGAVILEDGQELDSWYVILNGTVE-ISHPDGKIENLFMGNSFGIVPTLDKQHMHGAVRTKVDDCQ 367

  Fly   441 LLRVDKEHFNRILRDVEANTLRLQEHGKDVLV-----LERVAKQRGQHSAFKYTVMSGTPAKMLE 500
            .:.:.::.:.|||..||.||.:::|.|:.|:|     |:|...::|      :.|:..||.:::.
Mouse   368 FVCIAQQDYWRILNHVEKNTHKVEEEGEIVMVHEHRELDRSGTRKG------HIVIKATPERLIM 426

  Fly   501 HLLETRLGQSVGGMDP-FLDDFLLTHIVFMPV-VQLVDELANYFHCDAHEDAQT----------- 552
            ||:|.   .|:  :|| :::|||||:..|:.. :.:..:|..:|..|...|..|           
Mouse   427 HLIEE---HSI--VDPTYIEDFLLTYRTFLETPLDVGIKLLEWFKIDNLRDKVTRIVLLWVNNHF 486

  Fly   553 ------PEDREYIINFKK-----------RVIQF----MQKW----------------------- 573
                  |...:::..|::           |::..    ..||                       
Mouse   487 NDFEGDPAMTQFLEEFERNLEDTKMNGHLRLLNIACAAKAKWRQVVLQKASRESPLHFCLTGGSE 551

  Fly   574 --------------------------VMAVRHAAFEEPSVCDFIE-------------------- 592
                                      ||.|....||..::...:|                    
Mouse   552 KGFGVFVEEVESGSKAADAGLKRGDQVMEVNGQNFENITLAKALEILRNNTHLALTVKTNIFVFK 616

  Fly   593 DLAAEVEAD-------PDLNEETSIVHNVLTQMARYQEDRNQNAGQKWK---------------- 634
            :|.:..|.:       |.:.|:.|..|::.......::...:...:|.|                
Mouse   617 ELLSRTEQEKSGVPHIPKIAEKKSNRHSIQDVPGDMEQAPQEKGNKKIKANTVSGGRNKIRKILD 681

  Fly   635 ------LPPNGQPICLFSGN-----------------------------ATPSKTVIRPD----- 659
                  |||.     |||..                             ::.|..:::|.     
Mouse   682 KTRFSILPPK-----LFSDGGLSQSQDDSIVGTRHCRHSLAIMPIPGTLSSSSPDLLQPTTSMLD 741

  Fly   660 ------------DDIIFRVYCADHTYCTLRFPMHTTAELIKACAADKLQLNRGPEDLVLVEVKSN 712
                        .|.:.||:.||...|.:.....|||:.:...|..:..|....:...|.||...
Mouse   742 FSNPSAVGFYYIPDQVIRVFKADQQSCYIIISKDTTAKEVVCQAVQEFGLTGASDTYSLCEVSVT 806

  Fly   713 GERSVFK-----DNDVSIPTGLSLNGRLFVSVKDHLDALTQLQEQECPTEGVDIDLEI--LSTKE 770
            .| .|.|     |....:...:.||||.:  :|::::..|...:::......:..|.:  |||.|
Mouse   807 PE-GVIKQRRLPDQFSKLADRIQLNGRYY--LKNNMETETLCSDEDAQELLKESQLSMLQLSTIE 868

  Fly   771 LAYHITLFEWDLFWAVHEYELLYHTF------GRHHFGKITANLDVFLRRF----NEVQYWIVTE 825
            :|..:::.::|||..:...|.:...|      |..|           |::|    |:..:|:.:|
Mouse   869 VATQLSMRDFDLFRNIEPTEYIDDLFKLDSKTGNTH-----------LKQFEDIVNQETFWVASE 922

  Fly   826 LVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQE 890
            ::|..:..||:.:::.|||:|.:|:|.:|.|:.||::.||:...|:||:.||||:|||:.|..|:
Mouse   923 ILSESNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRGTWEKLPSKYEKHLQD 987

  Fly   891 FEALIDPSRNHRAYRVFVG--KLQPPLIPFMPLLLKDMTFAHEGNKTSLDGLVNFEKMHMMAQTM 953
            .:.|.|||||...||..:.  .:|||:||..|::.|||||.||||.:.:||||||||:.|:|:.:
Mouse   988 LQDLFDPSRNMAKYRNILSSQSMQPPIIPLFPVVKKDMTFLHEGNDSKVDGLVNFEKLRMIAKEI 1052

  Fly   954 RTI----------------RFCRSRSLG-LEPPSPKS-----EG--------------------- 975
            |.|                |..|.|||| |...|..|     :|                     
Mouse  1053 RHIIRMTSANMDPAMMFRQRKKRWRSLGSLSQGSTNSNMLDVQGGAHKKRARRSSLLNAKKLYED 1117

  Fly   976 -----EVRSYISSFRVIDNQRVLTAMSQKVEP 1002
                 :|:.|:||..:..::.....||.:.||
Mouse  1118 AQMARKVKQYLSSLDIDTDEEKFQMMSLQWEP 1149

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EpacNP_001097202.2 Crp 28..>146 CDD:223736 27/117 (23%)
CAP_ED 36..146 CDD:237999 24/109 (22%)
DEP_Epac 199..330 CDD:239884 19/131 (15%)
CAP_ED 352..463 CDD:237999 35/110 (32%)
Crp 373..525 CDD:223736 46/157 (29%)
RasGEF_N 489..594 CDD:279012 31/207 (15%)
UBQ 665..>714 CDD:294102 13/48 (27%)
RasGEF 766..1002 CDD:214539 95/295 (32%)
Rapgef6XP_006532623.1 CAP_ED 37..>82 CDD:381773 12/44 (27%)
CAP_ED 280..380 CDD:237999 29/100 (29%)
RasGEFN 412..525 CDD:214571 24/123 (20%)
PDZ_signaling 529..609 CDD:238492 6/79 (8%)
RA_PDZ-GEF1 756..838 CDD:340483 22/84 (26%)
RasGEF 862..1086 CDD:238087 86/234 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3629
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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