Protein Alignment Epac and epac-1

DIOPT Version :10

• Sequence 1: NP_001097202.2
• Gene: Epac / 35588
• FlyBaseID: FBgn0085421
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: NP_499256.2
• Gene: epac-1 / 176432
• WormBaseID: WBGene00004255
• Length: 1038
• Species: Caenorhabditis elegans
• Alignment Length: 1076
• Identity: 367/1076 - (34%)
• Similarity: 555/1076 - (51%)
• Gaps: 143/1076 - (13%)

  Fly    21 VELISCRLRRVEPLCRLPGSAL-QQLAMCGFYED-LEKGVTLFRAGEQGRFWYAVLGGSLEVRYH 83
            :|.|..|:||:.||.....:.| ..|:...|..| :::||.||...|...:||.:|.|.::: |.
 Worm     1 MERIVSRVRRLSPLHTFSDALLISLLSESDFQPDSIQQGVVLFEKDEPTEYWYLLLSGEVQL-YS 64

  Fly    84 AHADADGKSAVTL-CNLGVGATFGESVLHDLPRDSTVVTKTTCELLRVEQQDFRLIWEKNKE--- 144
            .....|.....|| |    ||.||:  |..|....:.:.....:|:|:.|..|..::.|:.:
 Worm    65 KTYTGDFNHLKTLRC----GALFGD--LSTLTHSCSCLVTRPAQLIRIAQNHFLSVYNKHGDHLQ 123

  Fly   145 ----LMNDIFT-----------NCKLKNG----------FGPSVQATAAATSPTKRPLSPDHPNP 184
                :|:||.|           :..|.||          ..||...:.:......:.:.|..||.
 Worm   124 PFIIIMHDILTDETPSDPIHPHSSGLFNGQRSMDLISTEINPSEIVSVSTNGMLSKMILPSIPNQ 188

  Fly   185 ALPITETPSPAMNRM----------------------------GWALRTLLVADNSSCLKDRKVS 221
                .|.|   |||:                            |..|...::.||...::|....
 Worm   189 ----REKP---MNRVVVNQQKNEERNFIEFHNPTGIEKQIRDSGGILHRKMLTDNHQVIRDITTE 246

  Fly   222 GKLIRKCAPGTELVDWLVNLSPIVHT------RAQAAGMWQALLEEGVLAHVNKEQPFKDKCFLY 280
            ...::.|..|.|::|||:.|.....|      |.|.:.:||.||..|:::|::.|..|.||...|
 Worm   247 HTRVQNCMIGAEMIDWLLTLFVSTSTTCSSLSRIQMSAIWQVLLNNGLISHIDGEHQFLDKTNSY 311

  Fly   281 -----RFRIDEEGGTAAAGVPQAEDLGAANEHIREALSALFQRGPDATLRMILRKPSHERTSEEL 340
                 :||             ....:..:.|.:.::::.|....|:....||:.||..||:.|||
 Worm   312 YRWVQQFR-------------SRNKVAPSIEEVSKSITLLSSVAPETLFLMIVSKPGFERSPEEL 363

  Fly   341 ELVFEELVHIAALSHLSTSIKRELSSIFVFEAHAQAGTILFNQGDEGRSWYILLKGSVDVVIHGK 405
            |:|:|||..|.|||||||.:||:||:....|.:..||:::|.||:.|..|||:|||:|:|.::||
 Worm   364 EVVYEELTFIKALSHLSTMVKRQLSNFVKVEQYVHAGSVVFRQGEIGVYWYIVLKGAVEVNVNGK 428

  Fly   406 GTVATLKTGDDFGKLALINDAPRAATIVLKENNCHLLRVDKEHFNRILRDVEANTLRLQEHGKDV 470
             .|..|:.|||||||||:||.|||||||..|::...|.|||.|||:||..|||||:||:::|:||
 Worm   429 -IVCLLREGDDFGKLALVNDLPRAATIVTYEDDSMFLVVDKHHFNQILHQVEANTVRLKDYGEDV 492

  Fly   471 LVLERVAKQRGQHSAFK----------YTVMSGTPAKMLEHLLETR---LGQSVGGMDPFLDDFL 522
            ||||:|...||  :|.:          |:||:|...|:||::||||   ||..:..:|.|::||:
 Worm   493 LVLEKVDIPRG--AALENSNSCNFNCGYSVMAGKAEKILEYVLETRIDALGDDISELDVFVEDFI 555

  Fly   523 LTHIVFMPVVQLVDELANYFH-------CDAHEDAQTPEDREYIINFKKRVIQFMQKWVMAVRHA 580
            |||..|||...:.:.|.:|:.       .|:..|:.|.|     :..|:||:||:..|...:|..
 Worm   556 LTHDAFMPDNTVCNFLKSYYFRTPYRATRDSITDSCTEE-----VRCKRRVVQFVYVWCSLLRVN 615

  Fly   581 AFEEPSVCDFIEDLAAEVEADPDLNEETSIVHNVLTQMARYQEDRNQNAGQKWKLPPNGQPICLF 645
            .|..|....|:|:|...|..|   .:....:.::||::...:..|     :..:|.....|..:.
 Worm   616 FFLNPVTNSFVEELFCHVIDD---RKRLGGMEDILTRIGSIRSTR-----ENMQLVLARHPAIVL 672

  Fly   646 SGNATPSKT--VIRPDDDIIFRVYCADHTYCTLRFPMHTTAELIKACAADKLQLNRGPEDLVLVE 708
            ......:.|  .:.|.|.....:|.||.|...|...:..|||.|  |...:.:::...|.|.|||
 Worm   673 DCGVLSAHTPCPVLPSDVCNQIIYLADTTCFVLPIRVDKTAEEI--CELSRRRMSFSAEPLNLVE 735

  Fly   709 VKSNGERSVFKDNDVSIPTGLSLNGRLFVSVKDHLDALTQLQEQECPTEGVDID-LEILSTKELA 772
            ||||||:.:|..||.:|||.||||.:|:|..::.:..|..:::|..||...... |.::.::|||
 Worm   736 VKSNGEKLIFSPNDRAIPTVLSLNSKLYVVNREEIPLLVPMEDQNGPTPSSHSSILHLIDSQELA 800

  Fly   773 YHITLFEWDLFWAVHEYELLYHTFGRHHFG-KITANLDVFLRRFNEVQYWIVTELVSTPSLSKRV 836
            :.:.||...|..:....||||...||..|. .:..|||:.:|||||||:|..||::.... ..|:
 Worm   801 HQLFLFHLQLLRSTDSNELLYQVIGRESFPLSMPFNLDLLVRRFNEVQHWSTTEILLATE-ENRM 864

  Fly   837 GLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNH 901
            .:::|||.:|...:||::|...||:.:|||:.::|||..||.|:|....|.|.|.|.|:||:|||
 Worm   865 EILKKFISIATIAREYRDLLTVFAITLGLSHTSISRLTLTWSKLPPASLKTFSELENLLDPTRNH 929

  Fly   902 RAYRVFVGKLQPPLIPFMPLLLKDMTFAHEGNKTSLDGLVNFEKMHMMAQTMRTIRFCRSRSLGL 966
            |.||:.|.|:..|.|||:||:|||:.|.|:|||:..:||||||||||.|:..|:.|.|:|:   :
 Worm   930 RMYRLLVSKMSSPYIPFVPLILKDLMFIHQGNKSFYNGLVNFEKMHMFAKIFRSFRQCKSQ---M 991

  Fly   967 EPPSPKSEGEVRSYISSFRVIDNQRVLTAMSQKVEP 1002
            :..:.....|.:|.|.:.||||||:.|..:|.::||
 Worm   992 DNGAEHEFIEPQSLIRNLRVIDNQKKLMQLSYEIEP 1027

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Epac	NP_001097202.2	CAP_ED	36..146	CDD:237999	29/119 (24%)
		DEP_Epac	199..330	CDD:239884	33/169 (20%)
		CAP_ED	352..463	CDD:237999	63/110 (57%)
		RasGEF_N	489..594	CDD:459873	39/114 (34%)
		Ubl1_cv_Nsp3_N-like	652..>722	CDD:475130	25/71 (35%)
		RasGEF	766..1002	CDD:214539	101/236 (43%)
epac-1	NP_499256.2	cNMP	19..129	CDD:197516	29/116 (25%)
		DEP_Epac	224..353	CDD:239884	33/141 (23%)
		CAP_ED	375..485	CDD:237999	63/110 (57%)
		RasGEFN	516..654	CDD:214571	45/145 (31%)
		RasGEF	791..1029	CDD:214539	104/241 (43%)