Protein Alignment Epac and Epac

DIOPT Version :10

• Sequence 1: NP_001097202.2
• Gene: Epac / 35588
• FlyBaseID: FBgn0085421
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: XP_061496580.1
• Gene: Epac / 1269861
• VectorBaseID: AGAMI1_014853
• Length: 1010
• Species: Anopheles gambiae
• Alignment Length: 1013
• Identity: 824/1013 - (81%)
• Similarity: 904/1013 - (89%)
• Gaps: 13/1013 - (1%)

  Fly     1 MAMEWITAMDKRPCDRNLRDVELISCRLRRVEPLCRLPGSALQQLAMCGFYEDLEKGVTLFRAGE 65
            ||||||||:|||||||||||.||||||||||||||||||||||||||||||||||||||||||||
Mosquito     1 MAMEWITAIDKRPCDRNLRDCELISCRLRRVEPLCRLPGSALQQLAMCGFYEDLEKGVTLFRAGE 65

  Fly    66 QGRFWYAVLGGSLEVRYHAHADADGKSAVTLCNLGVGATFGESVLHDLPRDSTVVTKTTCELLRV 130
            |||:|||||||.|||||||....|||.:|||||||||||||||:|||||||||||||||||||||
Mosquito    66 QGRYWYAVLGGQLEVRYHAADTKDGKLSVTLCNLGVGATFGESILHDLPRDSTVVTKTTCELLRV 130

  Fly   131 EQQDFRLIWEKNKELMNDIFTNCKLKNGFGPSVQATAAA-------TSPTKRPLSPDHPNPALPI 188
            ||||||||:||||||||||.|||:||||||.|:|.|:..       .||||:.|||||||||.||
Mosquito   131 EQQDFRLIFEKNKELMNDIITNCRLKNGFGQSMQTTSTVQTNVQQQPSPTKKQLSPDHPNPAAPI 195

  Fly   189 TETPSPAMNRMGWALRTLLVADNSSCLKDRKVSGKLIRKCAPGTELVDWLVNLSPIVHTRAQAAG 253
            ||.|||||:|||||||||||:||:||||||||.||.|||||||||||:||:|||||||||.||||
Mosquito   196 TEIPSPAMSRMGWALRTLLVSDNTSCLKDRKVGGKFIRKCAPGTELVEWLLNLSPIVHTRTQAAG 260

  Fly   254 MWQALLEEGVLAHVNKEQPFKDKCFLYRFRIDEEGGTAAAGVPQAEDLGAANEHIREALSALFQR 318
            |||||||||||.||.||||||||||||||:.||:|  .|.|.|.::|:..|||||||||.||..|
Mosquito   261 MWQALLEEGVLCHVAKEQPFKDKCFLYRFKSDEDG--TAGGAPTSDDVNHANEHIREALPALLHR 323

  Fly   319 GPDATLRMILRKPSHERTSEELELVFEELVHIAALSHLSTSIKRELSSIFVFEAHAQAGTILFNQ 383
            ||||||||||||||||||.||||||:|||:||||||||||||||||:||.||||||.|||:||||
Mosquito   324 GPDATLRMILRKPSHERTQEELELVYEELLHIAALSHLSTSIKRELASIIVFEAHAHAGTVLFNQ 388

  Fly   384 GDEGRSWYILLKGSVDVVIHGKGTVATLKTGDDFGKLALINDAPRAATIVLKENNCHLLRVDKEH 448
            |||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||
Mosquito   389 GDEGRSWYILLKGSVDVVIHGKGTVATLKEGDDFGKLALINDAPRAATIVLKENNCHLLRVDKEH 453

  Fly   449 FNRILRDVEANTLRLQEHGKDVLVLERVAKQRGQHSAFKYTVMSGTPAKMLEHLLETRLGQSVGG 513
            |||||||||||||||||||||||:||||||||| :||||||||||||.||||||||||||...|.
Mosquito   454 FNRILRDVEANTLRLQEHGKDVLILERVAKQRG-YSAFKYTVMSGTPQKMLEHLLETRLGGQAGP 517

  Fly   514 MDPFLDDFLLTHIVFMPVVQLVDELANYFHCDAHEDAQ--TPEDREYIINFKKRVIQFMQKWVMA 576
            .||||||||||||||||...|:||||..:|.||..|.:  :.||:||.:..|:||:||:|:||:|
Mosquito   518 NDPFLDDFLLTHIVFMPTPLLIDELAANYHADADIDLRQASEEDQEYFLTSKRRVVQFIQRWVLA 582

  Fly   577 VRHAAFEEPSVCDFIEDLAAEVEADPDLNEETSIVHNVLTQMARYQEDRNQNAGQKWKLPPNGQP 641
            ||||.|::|...:|||:||.:|||:|.|.||.||:|:||||::||||||..||.|||||||||||
Mosquito   583 VRHAVFDDPLAVEFIEELATDVEAEPALQEEASIIHHVLTQLSRYQEDRQMNATQKWKLPPNGQP 647

  Fly   642 ICLFSGNATPSKTVIRPDDDIIFRVYCADHTYCTLRFPMHTTAELIKACAADKLQLNRGPEDLVL 706
            ||||||| |.|||||||||||||||||||||||||||||.||||:||||||||||:.|.||||:|
Mosquito   648 ICLFSGN-THSKTVIRPDDDIIFRVYCADHTYCTLRFPMATTAEVIKACAADKLQIARLPEDLLL 711

  Fly   707 VEVKSNGERSVFKDNDVSIPTGLSLNGRLFVSVKDHLDALTQLQEQECPTEGVDIDLEILSTKEL 771
            |||||:|||.||||||||:||.||||||:|||.||||||||.|.|||.|||..|:|.|.||||::
Mosquito   712 VEVKSSGERVVFKDNDVSVPTALSLNGRIFVSPKDHLDALTPLPEQEVPTEAPDVDFEALSTKDV 776

  Fly   772 AYHITLFEWDLFWAVHEYELLYHTFGRHHFGKITANLDVFLRRFNEVQYWIVTELVSTPSLSKRV 836
            |||:|||:||||||||||||||||||||||.|||:|||||:|||||:|||:|||:|||.:|:||:
Mosquito   777 AYHMTLFDWDLFWAVHEYELLYHTFGRHHFNKITSNLDVFIRRFNEIQYWVVTEIVSTTNLTKRM 841

  Fly   837 GLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNH 901
            .||:|||||||:||||||||||||:||||||.|||||..||:|:||||||:|.|:||||||||||
Mosquito   842 SLVKKFIKLAAFCKEYQNLNAFFAIVMGLSNTAVSRLSMTWDKLPSKFRKLFTEYEALIDPSRNH 906

  Fly   902 RAYRVFVGKLQPPLIPFMPLLLKDMTFAHEGNKTSLDGLVNFEKMHMMAQTMRTIRFCRSRSLGL 966
            ||||:.|||||||:|||||||||||||||||||||||||||||||||||||||.:||||||.|.|
Mosquito   907 RAYRMSVGKLQPPVIPFMPLLLKDMTFAHEGNKTSLDGLVNFEKMHMMAQTMRAVRFCRSRHLVL 971

  Fly   967 EPPSPKSEGEVRSYISSFRVIDNQRVLTAMSQKVEPTR 1004
            :|||||:|.|:|:||..||.|||||||.:|||||||.|
Mosquito   972 DPPSPKNENEIRNYIRCFRTIDNQRVLNSMSQKVEPRR 1009

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Epac	NP_001097202.2	CAP_ED	36..146	CDD:237999	99/109 (91%)
		DEP_Epac	199..330	CDD:239884	104/130 (80%)
		CAP_ED	352..463	CDD:237999	105/110 (95%)
		RasGEF_N	489..594	CDD:459873	67/106 (63%)
		Ubl1_cv_Nsp3_N-like	652..>722	CDD:475130	61/69 (88%)
		RasGEF	766..1002	CDD:214539	192/235 (82%)
Epac	XP_061496580.1	None