DRSC/TRiP Functional Genomics Resources

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Protein Alignment Epac and RAPGEF4

DIOPT Version :9

Sequence 1:NP_001097202.2 Gene:Epac / 35588 FlyBaseID:FBgn0085421 Length:1006 Species:Drosophila melanogaster
Sequence 2:NP_008954.2 Gene:RAPGEF4 / 11069 HGNCID:16626 Length:1011 Species:Homo sapiens


Alignment Length:1043 Identity:511/1043 - (48%)
Similarity:685/1043 - (65%) Gaps:88/1043 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 EWITAMDKRPCDRNLRDVELISCRLRRVEPLCRLPGSALQQLAMCGFYEDLEKGVTLFRAGEQGR 68
            |||..:||||.:|:..||::|..||:.|:...:...:.|.|:.:||:||:||||:||||.|:.|.
Human    14 EWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGYYENLEKGITLFRQGDIGT 78

  Fly    69 FWYAVLGGSLEVRY---HAHADADGKSAVTLCNLGVGATFGESVLHDLPRDSTVVTKTTCELLRV 130
            .|||||.|||:|:.   .:|.|     |||:|.||:|..||||:|.:.||.:|:||:.:.||||:
Human    79 NWYAVLAGSLDVKVSETSSHQD-----AVTICTLGIGTAFGESILDNTPRHATIVTRESSELLRI 138

  Fly   131 EQQDFRLIWEKNKELMNDIFTNCKLKNGFGPSVQATAAATSPTKR--PLSPDHP--NPALPITET 191
            ||:||:.:|||.::.|..:     |...:|.....:.....|.|.  ||...|.  .||..||:.
Human   139 EQKDFKALWEKYRQYMAGL-----LAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPANTITKV 198

  Fly   192 PSPAMNRMGWALRTLLVADNSSCLKDRKVSGKLIRKCAPGTELVDWLVNLSPIVHTRAQAAGMWQ 256
            ||..:.|.|..||..:::.....::|||...|..|:|..|||||||::..:|.||:|.||.||||
Human   199 PSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQ 263

  Fly   257 ALLEEGVLAHVNKEQPFKDKCFLYRFRIDEEGGTAAAGVPQAEDLGAANEHIREALSALFQRGPD 321
            .|||:|||.||::|..|:||...|||..||.   ..|.:|..|:....:|.:::.:..|.|.|||
Human   264 VLLEDGVLNHVDQEHHFQDKYLFYRFLDDEH---EDAPLPTEEEKKECDEELQDTMLLLSQMGPD 325

  Fly   322 ATLRMILRKPSHERTSEELELVFEELVHIAALSHLSTSIKRELSSIFVFEAHAQAGTILFNQGDE 386
            |.:|||||||..:||.::||:::|||:||.|||||||::||||:.:.:||:||:.||:|||||:|
Human   326 AHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEE 390

  Fly   387 GRSWYILLKGSVDVVIHGKGTVATLKTGDDFGKLALINDAPRAATIVLKENNCHLLRVDKEHFNR 451
            |.||||:|||||:|||:|||.|.||..|||||||||:|||||||:|||:|:|||.||||||.|||
Human   391 GTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNR 455

  Fly   452 ILRDVEANTLRLQEHGKDVLVLERV------AKQRGQHSAFKYTVMSGTPAKMLEHLLET-RLGQ 509
            |||||||||:||:||.:||||||:|      :.|.......|||||||||.|:|||.||| ||..
Human   456 ILRDVEANTVRLKEHDQDVLVLEKVPAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEA 520

  Fly   510 SVG-GMDPFLDDFLLTHIVFMPVVQLVDELANYFHCDAHEDAQTPEDREYIINFKKRVIQFMQKW 573
            ::. ..|..|:||::.|.||||..||...|..::|....:..: .|..:|.:|.|:|||:.:.:|
Human   521 TLNEATDSVLNDFIMMHCVFMPNTQLCPALVAHYHAQPSQGTE-QEKMDYALNNKRRVIRLVLQW 584

  Fly   574 VMA---------VRHAAFEE--PSVCDFIEDLAAEVEADPDLNEETSIV----------HNVLTQ 617
            ...         |..|..||  .||.|....:||..|..|:|.:....:          |.||.|
Human   585 AAMYGDLLQEDDVSMAFLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQ 649

  Fly   618 MARYQEDRNQNAGQKWKLPPNGQPICLFSGNATPSKTVIRPDDDIIFRVYCADHTYCTLRFPMHT 682
            .....::|.|..          ||              ||..|:::|:|||.||||.|:|.|:.|
Human   650 QFNTGDERAQKR----------QP--------------IRGSDEVLFKVYCMDHTYTTIRVPVAT 690

  Fly   683 TAELIKACAADKLQLNRGPEDLVLVEVKSNGERSVFKDNDVSIPTGLSLNGRLFVSVKDHLDALT 747
            :.:.:.:..||||....|   |::|::.|.||:.|.|.||||:.|.|::|||||...::..|:||
Human   691 SVKEVISAVADKLGSGEG---LIIVKMSSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLT 752

  Fly   748 QLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHEYELLYHTFGRHHFGKITANLDVFL 812
            .|.|||.||.|.....|::|:|:|||.:|:::|:||..|||.||:|||||||:|.|.|||||:||
Human   753 PLPEQEGPTVGTVGTFELMSSKDLAYQMTIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFL 817

  Fly   813 RRFNEVQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQQTW 877
            |||||:|:|:|||:.....|||||.|::||||:||:||||:|||:|||:||||||:|||||..||
Human   818 RRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTW 882

  Fly   878 EKIPSKFRKIFQEFEALIDPSRNHRAYRVFVGKLQPPLIPFMPLLLKDMTFAHEGNKTSLDGLVN 942
            ||:||||:|.:.|||:|:||||||||||:.|.||:||||||||||:|||||.||||||.:|.|||
Human   883 EKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVN 947

  Fly   943 FEKMHMMAQTMRTIRFCRSRSLGLEPPSP------KSEGEVRSYISSFRVIDNQRVLTAMSQKVE 1001
            ||||.|:|.|.||:|:.||     :|.:|      |:..:||||:....||||||.|:.||.::|
Human   948 FEKMRMIANTARTVRYYRS-----QPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLE 1007

  Fly  1002 PTR 1004
            |.|
Human  1008 PRR 1010

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EpacNP_001097202.2 Crp 28..>146 CDD:223736 57/120 (48%)
CAP_ED 36..146 CDD:237999 55/112 (49%)
DEP_Epac 199..330 CDD:239884 57/130 (44%)
CAP_ED 352..463 CDD:237999 83/110 (75%)
Crp 373..525 CDD:223736 104/159 (65%)
RasGEF_N 489..594 CDD:279012 44/117 (38%)
UBQ 665..>714 CDD:294102 19/48 (40%)
RasGEF 766..1002 CDD:214539 152/241 (63%)
RAPGEF4NP_008954.2 CAP_ED 43..158 CDD:237999 56/124 (45%)
DEP_Epac 206..334 CDD:239884 57/130 (44%)
CAP_ED 356..467 CDD:237999 83/110 (75%)
RasGEF_N 499..605 CDD:395493 40/106 (38%)
RasGEF 768..1009 CDD:214539 154/245 (63%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 279 1.000 Domainoid score I1711
eggNOG 1 0.900 - - E1_KOG3629
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H4451
Inparanoid 1 1.050 949 1.000 Inparanoid score I341
Isobase 1 0.950 - 0.878984 Normalized mean entropy S3294
OMA 1 1.010 - - QHG49338
OrthoDB 1 1.010 - - D143470at2759
OrthoFinder 1 1.000 - - FOG0000899
OrthoInspector 1 1.000 - - oto89921
orthoMCL 1 0.900 - - OOG6_103967
Panther 1 1.100 - - O PTHR23113
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2054
SonicParanoid 1 1.000 - - X1712
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.820

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