Protein Alignment Epac and rapgef5

DIOPT Version :10

• Sequence 1: NP_001097202.2
• Gene: Epac / 35588
• FlyBaseID: FBgn0085421
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: XP_031759509.1
• Gene: rapgef5 / 100494102
• XenbaseID: XB-GENE-876513
• Length: 900
• Species: Xenopus tropicalis
• Alignment Length: 966
• Identity: 312/966 - (32%)
• Similarity: 479/966 - (49%)
• Gaps: 114/966 - (11%)

  Fly    79 EVRYHAHADADGKSAVTLCNLGVGATFGESVLHDLPRDSTVVTKTTCELLRVEQQDFRLIWEKNK 143
            ::|......:|....::|...|.|       :..|.|..:|         |.:|...:   .|.:
 Frog     5 QMRRKMQPTSDSSGPISLSPAGPG-------IPSLSRSRSV---------REQQAQLK---HKLR 50

  Fly   144 ELMNDIFTNCKLKNGF---------GPSV-----QATAAATSPTKRPLSPDHPNPALPI----TE 190
            ||      ...||:|.         |||.     :.||.|.:|:. |:.|:. .|:|.:    |:
 Frog    51 EL------PALLKSGLTLRRRSSVHGPSPSLCEGEDTAVAGNPSS-PILPER-IPSLYVDNSATK 107

  Fly   191 TPSPAMNRMGWALRTLLVADNSSCLKDRKVSGKLIRKCAPGTELVDWLVNLSPIVHTRAQAAGMW 255
            ....:::..|.|||..:.:.....::||.....:.||...|:||||||:...|.|..|..||.:|
 Frog   108 LYGESVSCAGRALRNAVRSQTPELIRDRMYLTCICRKSCVGSELVDWLLQHCPFVQCRYTAASIW 172

  Fly   256 QALLEEGVLAHVNKEQPFKDKCFLYRFRIDEEGGTAAAGVPQAEDLGAANEHIREALSALFQRGP 320
            |.||:.|:|..|:|:..|:|....|:|..:|.|.   ||.....|.|..     ..:..|.|..|
 Frog   173 QILLKLGILLSVDKQLCFQDTYVFYQFSSEECGD---AGCEFGRDKGWL-----MGVRLLKQLAP 229

  Fly   321 DATLRMILRKPSHERTSEELELVFEELVHIAALSHLSTSIKRELSSIFVFEAHAQAGTILFNQGD 385
            ...|...:...|.::.....| ...:::.|.||:.|:::::|||:::...:|....       ||
 Frog   230 LVPLTSNMCDVSADKLDHSNE-ANNKVLQIQALARLTSAVQRELAAVIALKARKSV-------GD 286

  Fly   386 EGRSWYILLKGSVDVVIHG----KGTVATLKTGDDFGKLALINDAPRAATIVLKENNCHLLRVDK 446
            |............|...|.    .|.:..|...::|.::..:..        ||..:..|....|
 Frog   287 EEEINCPQEAIQEDTAEHAAEAEAGVMCKLHGREEFRRIDFVQK--------LKRESQFLPSASK 343

  Fly   447 EHFNRILRDVEANTLRLQEHGKDVLVLERVAKQRGQHSA------FKYTVMSGTPAKMLEHLLET 505
            ....::.:|.|.:|::::|..:|||||::|..:....:|      ::|.|:||||.|:|||||..
 Frog   344 LPDKKLQQDEEESTVQVKEEDQDVLVLKKVLSESPAPTAGSAENDWRYMVVSGTPEKILEHLLND 408

  Fly   506 RLGQSV--GGMDPFLDDFLLTHIVFMPVVQLVDELANYFHCDAHED--AQTPEDREYIINFKKRV 566
            .....|  ...|..|||||||:.|||....|...|..:: |.|..|  |::||    .:..|::|
 Frog   409 LHLDEVQDKDTDTLLDDFLLTYTVFMTTDDLCKALLRHY-CAAKYDGKAESPE----ALCTKRKV 468

  Fly   567 IQFMQKWVMAVRHAAFEEPSVCDFIEDLAAEVEAD----PDLNEETSIVHNVLTQMARYQED--- 624
            :....:|....:....|:.....|::.|...|..|    |.|.:|......||....|:..|
 Frog   469 LLLASQWTALYKDWLHEDEHSKLFLKTLYRYVLDDVYEYPILEKELKEFQKVLRIHRRHTVDEYS 533

  Fly   625 ---RNQNAGQKWKLPPNGQPICLFSGNATPSKTVIRPDDDIIFRVYCADHTYCTLRFPMHTTAEL 686
               :|:....::.|..|.   ....|||...       ::|..|||..||:|.::|..:.::|:.
 Frog   534 PHRKNKALFHQFSLKENW---LQHRGNANEI-------EEIFCRVYITDHSYVSIRAKVSSSAQD 588

  Fly   687 IKACAADKLQLNRGPEDLVLVEVKSNGERSVFKDNDVSIPTGLSLNGRLFVSVKDHLDALTQLQE 751
            |....|:::||:.  |||.||.|...||:.....|::.:...|..:.|::...|.  |.|....|
 Frog   589 ILKIVAERIQLSE--EDLALVTVTYCGEKQELLPNELVLSKSLEPSSRIYTYRKS--DTLNPFAE 649

  Fly   752 QECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHEYELLYHTFGRHHFGKITANLDVFLRRFN 816
            .| .|:...:.|..::|.::|:.:|.|:|.||.::||.||:|.||.|...|:.|.||.:.|:|.|
 Frog   650 NE-ETQHRSVRLLGINTWDIAFELTSFDWSLFNSIHEQELIYFTFSRQGKGENTLNLSLLLQRCN 713

  Fly   817 EVQYWIVTELVSTPSLSKRVGLVRKFIKLAAYCKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIP 881
            |||.|:.||::......|||.|::||||:||:||..:|||:|||::|||:..:||||.|||||||
 Frog   714 EVQLWVATEILLCNQPGKRVQLLKKFIKIAAHCKAQRNLNSFFAIIMGLNTASVSRLSQTWEKIP 778

  Fly   882 SKFRKIFQEFEALIDPSRNHRAYRVFVGKLQPPLIPFMPLLLKDMTFAHEGNKTSLDGLVNFEKM 946
            .||:|:|.|.|:|.|||.||:|||....|::||.||||||||||:||.||||||.||.||||||:
 Frog   779 GKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKL 843

  Fly   947 HMMAQTMRTIRFCRSRSLGLEPPSPKSEGEVRSYISSFRVIDNQRVLTAMSQKVEP 1002
            ||:|..:|::|:||:...|.:.|. |...|.:.|.:...|||||:.|..:|.::||
 Frog   844 HMIADAVRSVRYCRNNQFGNDLPQ-KERQEAKFYSNHLHVIDNQQTLFELSHRIEP 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Epac	NP_001097202.2	CAP_ED	36..146	CDD:237999	12/66 (18%)
		DEP_Epac	199..330	CDD:239884	42/130 (32%)
		CAP_ED	352..463	CDD:237999	22/114 (19%)
		RasGEF_N	489..594	CDD:459873	36/108 (33%)
		Ubl1_cv_Nsp3_N-like	652..>722	CDD:475130	21/69 (30%)
		RasGEF	766..1002	CDD:214539	123/235 (52%)
rapgef5	XP_031759509.1	DEP_Epac	116..239	CDD:239884	42/130 (32%)
		RasGEFN	390..522	CDD:214571	44/136 (32%)
		Ubl1_cv_Nsp3_N-like	565..642	CDD:475130	24/80 (30%)
		RasGEF	660..900	CDD:214539	126/240 (53%)