Protein Alignment Epac and rgl3a

DIOPT Version :9

• Sequence 1: NP_001097202.2
• Gene: Epac / 35588
• FlyBaseID: FBgn0085421
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: XP_005165808.1
• Gene: rgl3a / 100149956
• ZFINID: ZDB-GENE-101130-1
• Length: 785
• Species: Danio rerio
• Alignment Length: 580
• Identity: 116/580 - (20%)
• Similarity: 201/580 - (34%)
• Gaps: 187/580 - (32%)

  Fly   535 VDE-----LANYFHCDAHEDAQTP-----EDRE----YIINFKKRVIQ-------------FMQK 572
            |||     |.::...|..|..:.|     |:.|    |.:...:..||             |||.
Zfish    35 VDEEPGVWLRSFHLLDLQEHTEDPVQEWGEEVEDGAIYGVTLHREPIQPPPDASESDAAFGFMQY 99

  Fly   573 WVMAVRHAAFEEPSVCDFIEDLAAEVEADPDLNEETSIVH------------NVLTQMARYQEDR 625
            ..:.||.  .:..::...:.:|......|||      .:|            |.|.::...:||.
Zfish   100 RTLKVRR--LKAATLDRLVTELVNPECPDPD------YMHIFLSTYRAFTCTNALIELLFQREDM 156

  Fly   626 NQNAGQKWKLPPNGQPICLFSGNATPSKTVIR-------------PDDDIIFRVYCAD--HTYCT 675
            ..|....         :|:.|  :.|  .:||             ||...: |:.|..  |..|.
Zfish   157 VTNLNNS---------VCVKS--SLP--RLIRLWLDEFHEDLRDSPDHQAL-RLLCVHLRHRLCC 207

  Fly   676 LRFPMHTTAELIKACAADKLQLNRGPEDLVLVEVKSNGERSVFKDNDVSIPTGLSLNGRLF--VS 738
            .|......|.|.|                             |:..|..|.|...:|....  .:
Zfish   208 RRLVNQADALLRK-----------------------------FQTEDKQICTSAEVNASAVENPA 243

  Fly   739 VKDHLDALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHEYELLYHTFG------ 797
            .:|:||.      ||....|..:|   ...:::|..:|:.:.:||..|    :.:|..|
Zfish   244 TEDNLDG------QEVQEIGDVLD---FPAQDIAEQLTILDAELFSKV----VPFHCLGCIWSQR 295

  Fly   798 -RHHFGKITANLDVFLRRFNEVQYWIVTELVSTPSLSK-------------RVGLVRKFIKLAAY 848
             :.....:.:.:...:.:||.|...::|.|:..|:.|.             |..::.|:|.:|..
Zfish   296 DKKENQNLVSTVRATIAQFNVVTNCVITSLLCPPATSPPGSPSCHRSSPTYRAKIIEKWISVAQE 360

  Fly   849 CKEYQNLNAFFAVVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALID--PSRN----HRAYRVF 907
            |.:.:|.::..|::..|.:.||.||::||..|.   |:....||.|.|  |..|    :|...|.
Zfish   361 CHQLRNFSSLRAILSALQSNAVYRLKKTWAVIS---RESMAVFEHLCDTFPDENCVLINREILVE 422

  Fly   908 VG---------------KLQPPL----------IPFMPLLLKDMTFAHEGNKTSLD-GLVNFEKM 946
            .|               :|.|..          :|::...|..:|........::: ||:||||.
Zfish   423 EGNQAADVETHSAPKSPRLSPTCKHMQSSSSGEVPYLGTYLTVLTMLDTALTDNVEGGLINFEKR 487

  Fly   947 HMMAQTMRTIR----FCRSRSLGLEPPSPKSEGEVRSYISSFRVIDNQRVLTAMSQKVEP 1002
            ....:.:..||    .|...:|       :|...:.|:|:|...:.:|:.. .:|:::||
Zfish   488 RKEFEILSLIRQLQASCAHYTL-------QSHPRIISWINSSMSLSDQKSY-ELSRELEP 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Epac	NP_001097202.2	Crp	28..>146	CDD:223736
		CAP_ED	36..146	CDD:237999
		DEP_Epac	199..330	CDD:239884
		CAP_ED	352..463	CDD:237999
		Crp	373..525	CDD:223736
		RasGEF_N	489..594	CDD:279012	17/85 (20%)
		UBQ	665..>714	CDD:294102	8/50 (16%)
		RasGEF	766..1002	CDD:214539	60/291 (21%)
rgl3a	XP_005165808.1	RasGEF_N	106..189	CDD:279012	15/103 (15%)
		RasGEF	259..541	CDD:214539	63/299 (21%)
		RalGDS_RA	677..763	CDD:176351

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810