Protein Alignment Epac and ralgds

DIOPT Version :9

• Sequence 1: NP_001097202.2
• Gene: Epac / 35588
• FlyBaseID: FBgn0085421
• Length: 1006
• Species: Drosophila melanogaster
• Sequence 2: XP_012823402.1
• Gene: ralgds / 100135084
• XenbaseID: XB-GENE-987988
• Length: 856
• Species: Xenopus tropicalis
• Alignment Length: 567
• Identity: 105/567 - (18%)
• Similarity: 191/567 - (33%)
• Gaps: 190/567 - (33%)

  Fly   489 TVMSGTPAKMLEHLLETRLGQSVGGMDPFLDDFLLTHIVFMPVVQLVDELANYF-----HCDAHE 548
            ::.:||..|::|:|:....|..    ..::..||.|:..|....|::|.|.|.|     ..:...
 Frog   138 SIKAGTLEKLVEYLVSAFKGND----STYVTIFLCTYRAFATTKQVLDLLLNRFGRLHPQINGEH 198

  Fly   549 DAQTPEDREYIINFKKRVIQFMQKWVMAVRHAAFEEPS-VCDFIEDLAAEVEAD---PDLNEETS 609
            ...:.:||   :..|..:...:..|:........:.|. .|  ::.|...|..:   .||.....
 Frog   199 SHNSVDDR---LELKNTISSILGAWLDQYSEDFRQAPDYTC--LKQLITYVRHNIPGSDLERRAC 258

  Fly   610 IVHNVLTQMARYQEDRNQNAGQKWKLPPNGQPICLFSGNATPSKTVIRPDDDIIFRVYCADHTYC 674
               |:|||..|.|                              .:.:.||        ..|||.|
 Frog   259 ---NLLTQFKRQQ------------------------------ISALEPD--------VVDHTSC 282

  Fly   675 TLRFPMHTTAELIKACAADKLQLNRGPEDLVLVEVKSNGERSVFKDNDVSIPTGLSLNGRLFVSV 739
            |||                          ||...:.|:|:..                   |:|.
 Frog   283 TLR--------------------------LVEEPLLSDGKPD-------------------FLSF 302

  Fly   740 KDHLDALTQLQEQECPTEGVDIDLEILSTKELAYHITLFEWDLFWAVHEYELLYHTFG-----RH 799
            :..:                           ||...|:.:.:||..|    :.||..|     |.
 Frog   303 RQDM---------------------------LAEQFTVMDAELFKKV----VPYHCLGCIWSQRD 336

  Fly   800 HFGK--ITANLDVFLRRFNEVQYWIVTELVSTPSL--SKRVGLVRKFIKLAAYCKEYQNLNAFFA 860
            ..||  :...:...:.:||.|...:::..:...||  .:|..::.::|::|..|:..:|.::..|
 Frog   337 KKGKEHLAPTIRATVSQFNSVTNCVISTCLCDRSLKPQQRAKVIERWIEVARECRILKNFSSLRA 401

  Fly   861 VVMGLSNMAVSRLQQTWEKIPSKFRKIFQEFEALIDPSRNHRAYRVFVGK----------LQPP- 914
            ::..|...|:.||::||:::..:..:||.|...:.....||...|..:.|          :.|.
 Frog   402 ILSALQCNAIHRLKKTWDEVSRESYRIFMELSEIFSDENNHSLSRELLIKEGTSKFATLDINPKR 466

  Fly   915 ----------------LIPFMPLLLKDMTFAHEGNKTSLD-GLVNFEKMHMMAQTMRTIRFCRS- 961
                            .||::...|.|:.......|..|: ||:||||.....:.:..|:..:|
 Frog   467 AQKRQQQQREMGVMQGTIPYLGTFLTDLVMLDTAMKDYLESGLINFEKRRKEFEVIAQIKLLQSA 531

  Fly   962 -RSLGLEPPSPKSEGEVRSYISSFRVIDNQRVLT-----AMSQKVEP 1002
             .:....|.        .|::..|..::.   ||     ::|.::||
 Frog   532 CNNYSFLPD--------ESFVEWFHSVER---LTEAESYSLSCEIEP 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Epac	NP_001097202.2	Crp	28..>146	CDD:223736
		CAP_ED	36..146	CDD:237999
		DEP_Epac	199..330	CDD:239884
		CAP_ED	352..463	CDD:237999
		Crp	373..525	CDD:223736	8/35 (23%)
		RasGEF_N	489..594	CDD:279012	21/110 (19%)
		UBQ	665..>714	CDD:294102	10/48 (21%)
		RasGEF	766..1002	CDD:214539	57/279 (20%)
ralgds	XP_012823402.1	RasGEFN	135..265	CDD:214571	29/138 (21%)
		RasGEF	299..564	CDD:238087	59/306 (19%)
		RA_RalGDS	740..825	CDD:340729

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910