DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Epac and Gm3404

DIOPT Version :9

Sequence 1:	NP_001097202.2	Gene:	Epac / 35588	FlyBaseID:	FBgn0085421	Length:	1006	Species:	Drosophila melanogaster
Sequence 2:	XP_011239299.1	Gene:	Gm3404 / 100041554	MGIID:	3781582	Length:	311	Species:	Mus musculus

Alignment Length:	252	Identity:	49/252 - (19%)
Similarity:	85/252 - (33%)	Gaps:	95/252 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   542 FHC------DAHEDAQTPEDREYIINFKKRVIQFMQKWVMAVRHAAFEEPSVCDFIEDLAAEVEA 600
            |.|      ..|:.|::    .:::.|.:|:|:.:..:    |||:..||.||...|.....:..
Mouse     2 FSCFQGSRGSGHKKAKS----GFLVRFWRRLIRPLTHF----RHASHSEPKVCSQNEQEPDSLPK 58

  Fly   601 DPDLNEETSIVHNVLTQMARYQEDRNQNAGQKWKLPPNGQP---IC--LFSGNATPSKTVIRPDD 660
            .|..|.::   ...:.||..|             :|...|.   ||  :|.|
Mouse    59 RPQFNYDS---QEYVVQMIHY-------------IPAAIQKRDHICITIFLG------------- 94

  Fly   661 DIIFRVYCADHTYCTLRFPMHTTAELIKACAADKLQLNRG------------PEDLVLVEVKSNG 713
              ::|.|.:  |:..|...|.|.|.....|..|: |..|.            |:|.
Mouse    95 --VYRTYAS--TWEVLDLLMRTYASFRPDCIKDQ-QTKRAIFRFLFGWFKKYPQDF--------- 145

  Fly   714 ERSVFKDNDVSIPTGLSLNGRLFVSVKDHLDALTQLQEQECPTEGVDIDLEILSTKE 770
                ::..|:::             |:..:|.:    ::..|:..||...|:||..|
Mouse   146 ----YESPDLAV-------------VRQFIDYV----KRNVPSSDVDRARELLSVLE 181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Epac	NP_001097202.2	Crp	28..>146	CDD:223736
		CAP_ED	36..146	CDD:237999
		DEP_Epac	199..330	CDD:239884
		CAP_ED	352..463	CDD:237999
		Crp	373..525	CDD:223736
		RasGEF_N	489..594	CDD:279012	15/57 (26%)
		UBQ	665..>714	CDD:294102	13/60 (22%)
		RasGEF	766..1002	CDD:214539	3/5 (60%)
Gm3404	XP_011239299.1	REM	89..177	CDD:100121	22/135 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3629
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900