DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a2 and ERG11

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_011871.1	Gene:	ERG11 / 856398	SGDID:	S000001049	Length:	530	Species:	Saccharomyces cerevisiae

Alignment Length:	480	Identity:	121/480 - (25%)
Similarity:	191/480 - (39%)	Gaps:	85/480 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 YWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKSGFPFV------GFYFLHKPAAFI 83
            ||    :|......:||        ...::||.:...||... |.||      ..|...|...|:
Yeast    61 YW----IPWVGSAVVYG--------MKPYEFFEECQKKYGDI-FSFVLLGRVMTVYLGPKGHEFV 112

  Fly    84 VDTQLAKNILIKDFSNFADRGQFHNGRDDPLTQHLFN----LDGKKWKDMRQRLTPTFTSGKM-K 143
            .:.:||      |.|  |:....|      ||..:|.    .|....:.|.|:   .|..|.: |
Yeast   113 FNAKLA------DVS--AEAAYAH------LTTPVFGKGVIYDCPNSRLMEQK---KFVKGALTK 160

  Fly   144 FMFPTVIK-VSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTCAFGIECNTLRTPV-SDF 206
            ..|.:.:. ::||..|...:......|.......::|.......|.|.:..:....:|..: :||
Yeast   161 EAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEMRAKLDTDF 225

  Fly   207 RTMGQKVFTDMRHGKLLTMFVFSFPKL-ASRLRMRMMPEDVHQFFMRLVNDTIALRERENFKRND 270
            ..:    ::|:..|  .|...|.||.| ....|.|       ....:.::.|.....:|..|.||
Yeast   226 AYL----YSDLDKG--FTPINFVFPNLPLEHYRKR-------DHAQKAISGTYMSLIKERRKNND 277

  Fly   271 FMNL-LIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQD 334
            ..:. ||:...|.. |..:|..:...:|..|...|.   :.|..||::|.::.|..||:..|:|.
Yeast   278 IQDRDLIDSLMKNS-TYKDGVKMTDQEIANLLIGVL---MGGQHTSAATSAWILLHLAERPDVQQ 338

  Fly   335 RLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALNDYVVPGHEKLVIEK 399
            .|..|...||:..:.:|||:.::.|..|||.|.||||::..:..|.||.:.|..|| :...||..
Yeast   339 ELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVP-NTSYVIPA 402

  Fly   400 GTQVII-PACAYHRDEDLYPNPETFDPERFSPEKVAA---RESVE-------------WLPFGDG 447
            |..|:: |...:.||| .:||...|:..|::.:..::   .|.|:             :||||.|
Yeast   403 GYHVLVSPGYTHLRDE-YFPNAHQFNIHRWNKDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGG 466

  Fly   448 PRNCIGMRFGQMQARIGLAQIISRF 472
            ...|||..|...|    |..::|.|
Yeast   467 RHRCIGEHFAYCQ----LGVLMSIF 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	118/469 (25%)
ERG11	NP_011871.1	CYP51-like	83..521	CDD:410668	114/446 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I1492
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I1477
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960