Protein Alignment Cyp6a2 and ERG5

DIOPT Version :10

• Sequence 1: NP_523628.1
• Gene: Cyp6a2 / 35587
• FlyBaseID: FBgn0000473
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_013728.1
• Gene: ERG5 / 855029
• SGDID: S000004617
• Length: 538
• Species: Saccharomyces cerevisiae
• Alignment Length: 531
• Identity: 116/531 - (21%)
• Similarity: 196/531 - (36%)
• Gaps: 112/531 - (21%)

  Fly     1 MFVLIYLLIAISSLLAYLYHR------NFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDY 59
            :|..:..::.:...:||...:      .|.:|           |:.|..:     ..:...|.:|
Yeast    48 IFATLICILLVWDQVAYQIKKGSIAGPKFKFW-----------PIIGPFL-----ESLDPKFEEY 96

  Fly    60 YNKYRKSGFPFVGFYFLHKPAAFIVDTQLAKNILIKDFSNFADRGQFHNGRDDPLT--------- 115
            ..|:.......|..:  ||.........||:.||  ..|.|.          .|..
Yeast    97 KAKWASGPLSCVSIF--HKFVVIASTRDLARKIL--QSSKFV----------KPCVVDVAVKILR 147

  Fly   116 --QHLFNLDGKKWKDMRQRLTPTFTSGKMKFMFPT----VIKVSEEFVKVITEQVPAAQNGAVL- 173
              ..:| ||||...|.|:.|...||...:....|:    :.|..::||::..|.....|   |.
Yeast   148 PCNWVF-LDGKAHTDYRKSLNGLFTKQALAQYLPSLEQIMDKYMDKFVRLSKENNYEPQ---VFF 208

  Fly   174 -EIKELMARFTTDVIGTCAFGIECNTLRTPVSDFRTMGQKV----------FTDMRHGKLLTMFV 227
             |::|::...:.:  ..|...|..:.:|....|:..:...:          :|...:||
Yeast   209 HEMREILCALSLN--SFCGNYITEDQVRKIADDYYLVTAALELVNFPIIIPYTKTWYGK------ 265

  Fly   228 FSFPKLASRLRMRMMPEDVHQFFMRLVNDTIALRERENFKRNDFMNLLIELKQKGRVTLDNGEVI 292
                |.|.      |...:.:...::..|.||...:.....:.:..|:.:.|...    |:...|
Yeast   266 ----KTAD------MAMKIFENCAQMAKDHIAAGGKPVCVMDAWCKLMHDAKNSN----DDDSRI 316

  Fly   293 EGMDI--GELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTVL-EEQEGQLTYE 354
            ...:.  .|::..||.|..|..:.|||...:....:|...|:..::|.|...|. .:...:|..:
Yeast   317 YHREFTNKEISEAVFTFLFASQDASSSLACWLFQIVADRPDVLAKIREEQLAVRNNDMSTELNLD 381

  Fly   355 SIKAMTYLNQVISETLRL---YTLVPHLERKALNDYVVPGHEKLVIEKGTQVIIPAC--AYHRDE 414
            .|:.|.|.|.||.||||.   ..:||::.:|  |..|.|.:   ...||. ::||..  |.| |.
Yeast   382 LIEKMKYTNMVIKETLRYRPPVLMVPYVVKK--NFPVSPNY---TAPKGA-MLIPTLYPALH-DP 439

  Fly   415 DLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRVSVCDT 479
            ::|.||:.|.|||:.....|:.....||.||.||..|:    ||....|..|.::.:|.:    .
Yeast   440 EVYENPDEFIPERWVEGSKASEAKKNWLVFGCGPHVCL----GQTYVMITFAALLGKFAL----Y 496

  Fly   480 TEIPLKYSPMS 490
            |:.....:|:|
Yeast   497 TDFHHTVTPLS 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	CYP6-like	69..500	CDD:410679	106/457 (23%)
ERG5	NP_013728.1	CYP61_CYP710	103..522	CDD:410703	106/460 (23%)