Protein Alignment Cyp6a2 and CYP4F2

DIOPT Version :10

• Sequence 1: NP_523628.1
• Gene: Cyp6a2 / 35587
• FlyBaseID: FBgn0000473
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_001073.3
• Gene: CYP4F2 / 8529
• HGNCID: 2645
• Length: 520
• Species: Homo sapiens
• Alignment Length: 537
• Identity: 136/537 - (25%)
• Similarity: 240/537 - (44%)
• Gaps: 75/537 - (13%)

  Fly     4 LIYLLIAISSLLAYLY--------------------HRNFNYWNRRGVPHDAPHPLYGNMVGFRK 48
            |:.||:..|.|||::.                    .||: :|..:|:.:.....:
Human    20 LLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNW-FWGHQGMVNPTEEGM--------- 74

  Fly    49 NRVMHDFFYDYYNKYRKSGFPFVGFYFLHKPAAFIVDTQLAKNILIKDFSNFADRGQFHNGRDDP 113
             ||:......|...::....|.       .|...:....:.::: |...:..|.:.:|.....:|
Human    75 -RVLTQLVATYPQGFKVWMGPI-------SPLLSLCHPDIIRSV-INASAAIAPKDKFFYSFLEP 130

  Fly   114 -LTQHLFNLDGKKWKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITE--QVPAAQNGAVLEI 175
             |...|....|.||...|:.|||.|....:|    ..:|:..|.|.::..  |:.|::..|.|::
Human   131 WLGDGLLLSAGDKWSRHRRMLTPAFHFNILK----PYMKIFNESVNIMHAKWQLLASEGSACLDM 191

  Fly   176 KELMARFTTDVIGTCAFGIECNTLRTPVSDF--RTMGQKVFTDMRHGKLLTMFVFSFPKLASRLR 238
            .|.::..|.|.:..|.|..:.:....| |::  ..:........||.::|....|.:.......|
Human   192 FEHISLMTLDSLQKCVFSFDSHCQEKP-SEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQR 255

  Fly   239 MRMMPEDVHQFFMRLVND---TIA-------LRERENFKRNDFMNLLIELKQKGRVTLDNGEVIE 293
            .|.....||.|...::.:   |:.       |:.:...|..||:::|:..|.      ::|:.:.
Human   256 FRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKD------EDGKKLS 314

  Fly   294 GMDIGELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQE-GQLTYESIK 357
            ..||   .|:...|...|.:|::|.:|:.||.||::.:.|:|.|.|:|.:|:::| .::.::.:.
Human   315 DEDI---RAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLA 376

  Fly   358 AMTYLNQVISETLRLYTLVPHLERKALNDYVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPET 422
            .:.:|...:.|:|||:..||.:.|....|.|:|  :..||.||...:|.....|.:..::|:||.
Human   377 HLPFLTMCMKESLRLHPPVPVISRHVTQDIVLP--DGRVIPKGIICLISVFGTHHNPAVWPDPEV 439

  Fly   423 FDPERFSPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYS 487
            :||.||.||.:..|..:.::||..|||||||..|...:.::.||..:.|||| :.|.||...|
Human   440 YDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRV-LPDHTEPRRK-- 501

  Fly   488 PMSIVLGTVGGIYLRVE 504
             ..:||...||::||||
Human   502 -PELVLRAEGGLWLRVE 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	CYP6-like	69..500	CDD:410679	118/446 (26%)
CYP4F2	NP_001073.3	CYP4F	74..515	CDD:410772	121/478 (25%)