DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a2 and CYP709B2

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_182218.2	Gene:	CYP709B2 / 819309	AraportID:	AT2G46950	Length:	572	Species:	Arabidopsis thaliana

Alignment Length:	576	Identity:	138/576 - (23%)
Similarity:	234/576 - (40%)	Gaps:	132/576 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFVLIYLLIAISSLLA----------------------YLYHRNFNYWNRRGVPHDAPHPLYGNM 43
            :||:...|::..:|||                      ::..|.|   .::|:.......||||:
plant    51 LFVIRMELLSTINLLAIALVLLVVPKIYGACRILVWRPWMLSRRF---KKQGISGPKYRILYGNL 112

  Fly    44 VGFRK------------------NRVMHDFFYDYYNKYRKSGFPFVGFYFLH----KPAAFIVDT 86
            ...||                  .||: .....:.::|        |..||:    .|...|.|.
plant   113 REIRKMKNEAKLMVLDPNSNDIVPRVL-PHLQQWKSQY--------GETFLYWQGTDPRLCISDH 168

  Fly    87 QLAKNILIKDFSNFADRGQFHNGRDDP----LTQH-LFNLDGKKWKDMRQRLTPTFTSGKMKFMF 146
            :|||.||...|..|:      ..:..|    |:.: |..::|..|...|:.|.|.|:..|:|.|.
plant   169 ELAKQILSNKFVFFS------KSKTKPEILKLSGNGLIFVNGLDWVRHRRILNPAFSMDKLKLMT 227

  Fly   147 PTVIKVSEEFVKVITEQVPAAQNGAVLE----IKELMARFTTDVIGTCAFGIECNTLRTPVSDFR 207
            ..::..:........:|    :||...|    |.....|.|.|:|.|.|||   ::....:..|:
plant   228 QLMVDCTFRMFLEWKKQ----RNGVETEQFVLISREFKRLTADIIATAAFG---SSYAEGIEVFK 285

  Fly   208 TMGQ------KVFTDMRHGKLLTMFVFSFPKL-----ASRLRMRMMPEDVHQFFMRLVNDTIALR 261
            :..:      ...||:           .||.:     .|.|::..:...|:....|:::..:...
plant   286 SQLELQKCCAAALTDL-----------YFPGIQYLPTPSNLQIWKLDMKVNSSIKRIIDARLTSE 339

  Fly   262 ERENFKRNDFMNLLIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYCLYEL 326
            .::  ..||.:.:::       ....:.|..:.|.|.|:..:...|:.||.||:::.:::....|
plant   340 SKD--YGNDLLGIML-------TAASSNESEKKMSIDEIIEECKTFFFAGHETTANLLTWSTMLL 395

  Fly   327 AQNQDIQDRLRNEI-----QTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALND 386
            :.:||.|::||.|:     :..:.:.|   |...:|.|   |.|..|:||||..|.:|.|.|..|
plant   396 SLHQDWQEKLREEVFNECGKDKIPDAE---TCSKLKLM---NTVFMESLRLYGPVLNLLRLASED 454

  Fly   387 YVVPGHEKLVIEKGTQVIIPACAYHRDEDLY-PNPETFDPERFSPE-KVAARESVEWLPFGDGPR 449
            ..:   ..|.|.|||.:|:|....|||:.:: .:.:.|:|.||:.. ..||......|.|..|||
plant   455 MKL---GNLEIPKGTTIILPIAKMHRDKAVWGSDADKFNPMRFANGLSRAANHPNALLAFSMGPR 516

  Fly   450 NCIGMRFGQMQARIGLAQIISRFRVSV-CDTTEIP---LKYSP---MSIVLGTVGG 498
            .|||..|..|:|:..||.|:.|||::: .|....|   |...|   :.::|..:.|
plant   517 ACIGQNFAIMEAKTVLAMILQRFRLNLSADYKHAPADHLTLQPQYDLPVILEPIDG 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	129/519 (25%)
CYP709B2	NP_182218.2	p450	89..571	CDD:299894	131/535 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810