Protein Alignment Cyp6a2 and TBXAS1

DIOPT Version :10

• Sequence 1: NP_523628.1
• Gene: Cyp6a2 / 35587
• FlyBaseID: FBgn0000473
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 578
• Identity: 143/578 - (24%)
• Similarity: 264/578 - (45%)
• Gaps: 94/578 - (16%)

  Fly     3 VLIYLLIAISSLLAYLYHRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKSG 67
            |.:.|.:|:.:||.:.....|:...:.|:.|..|.|..||:..||:.      |::...:.||..
Human    16 VTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQG------FWESQMELRKLY 74

  Fly    68 FPFVGFYFLHKPAAFIVDTQLAKNILIKDFSNFADRG----QFHNGRDDPLTQHLFNLDGKKWKD 128
            .|..|:|...:....|.:..:.|.:|:::||||.:|.    :|.:..|..|.     |..|:|::
Human    75 GPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEFKSVADSVLF-----LRDKRWEE 134

  Fly   129 MRQRLTPTFTSGKM----------------------------KFMFPTVIKVSEEFVKVITEQVP 165
            :|..|...|:..|:                            :...|:.|.|:..:..:....||
Human   135 VRGALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATLPFCMVP 199

  Fly   166 A---------------AQNGAVLEIKELMARFTTDVIGTCAFGIECNTLRTPVSDFRTMGQKVFT 215
            .               |::|...:|:.....:||||:.:.|||...::.:.|...| ....|.|.
Human   200 LISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPF-VKHCKRFF 263

  Fly   216 DMRHGKLLTMFVFSFPKLASRLRMRMMP----EDVHQFFMRLVNDTIALRERE--NFKRNDFMNL 274
            :....:.:.:.:.|||.:...| .|::|    ::::.||.:|:.:.||||:::  ..:|.||:.:
Human   264 EFCIPRPILVLLLSFPSIMVPL-ARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQM 327

  Fly   275 LIELKQKGR-VTLDNGEVIEG-----------------------MDIGELAAQVFVFYVAGFETS 315
            :::.:.... :.:.:.:::..                       :.:.|:..|.|:|.:||:|..
Human   328 VLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEII 392

  Fly   316 SSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLE 380
            ::|:|:..|.||.|.|.|::|..|:....|:..........:.:.||:.||:||||:|.......
Human   393 TNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFT 457

  Fly   381 RKALNDYVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFG 445
            |:|..|..|.|..   |..|..:.:...|.|.|.:.:|:||||:||||:.|.........:||||
Human   458 REAAQDCEVLGQR---IPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFG 519

  Fly   446 DGPRNCIGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPMSIVLGTVGGIYLRV 503
            .|||:|:|:|.|.::.::.|..::.:||...|..|::||:....| .||...|:|:::
Human   520 AGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKS-ALGPKNGVYIKI 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	CYP6-like	69..500	CDD:410679	125/507 (25%)
TBXAS1	NP_001159725.2	cytochrome_P450	73..573	CDD:477761	125/510 (25%)