Protein Alignment Cyp6a2 and CYP3A43

DIOPT Version :10

• Sequence 1: NP_523628.1
• Gene: Cyp6a2 / 35587
• FlyBaseID: FBgn0000473
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_073731.1
• Gene: CYP3A43 / 64816
• HGNCID: 17450
• Length: 504
• Species: Homo sapiens
• Alignment Length: 496
• Identity: 146/496 - (29%)
• Similarity: 248/496 - (50%)
• Gaps: 32/496 - (6%)

  Fly     6 YLLIAISSLLAYLY----HRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKS 66
            ::|:|.|.:|.|:|    |:.|   .:.|:|...|.|..|.::.:.  |.:.:|..:...||.:
Human    12 WVLVATSLVLLYIYGTHSHKLF---KKLGIPGPTPLPFLGTILFYL--RGLWNFDRECNEKYGE- 70

  Fly    67 GFPFVGFYFLHKPAAFIVDTQLAKNILIKD-FSNFADRGQFHNGRDDPLTQHLFNLDGKKWKDMR 130
               ..|.|...:|...|:|..:.|.:|:|: :|.|.:  |...|....|...|...:.::||.:|
Human    71 ---MWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTN--QMPLGPMGFLKSALSFAEDEEWKRIR 130

  Fly   131 QRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTCAFGIE 195
            ..|:|.|||.|.|.|.|.:.:..:..|:.:.::   |:|...:.:|:....:|.|||....||:.
Human   131 TLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQE---AENSKSINLKDFFGAYTMDVITGTLFGVN 192

  Fly   196 CNTLRTPVSDF-RTMGQKVFTDMRHGKLLTMFVFSF-PKLASRLRMRMMPEDVHQFFMRLVNDTI 258
            .::|..|...| :.|.:.:..|.....||.:.:|.| ..:...|.:.:.|:||..|....:....
Human   193 LDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMK 257

  Fly   259 ALRERENFK-RNDFMNLLIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYC 322
            ..|.::..| |.||...:|: .|..:.|..:    :.:...||.||..:...|.::|:|:|:.:.
Human   258 ESRLKDKQKHRVDFFQQMID-SQNSKETKSH----KALSDLELVAQSIIIIFAAYDTTSTTLPFI 317

  Fly   323 LYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALNDY 387
            :||||.:.|:|.:|:.||..|| ..:..:||:::..|.||:.|::|||||:.:|..:.|....|.
Human   318 MYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDI 381

  Fly   388 VVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPE-RFSPEKVAARESVEWLPFGDGPRNC 451
            .:.|   :.|.||..|::|..|.|.|...:..||.|.|| |||.:...:.:...::|||.|||||
Human   382 EING---VFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPRNC 443

  Fly   452 IGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPMSIV 492
            |||||.....::.:.:.:..|....|..|:||||...:.|:
Human   444 IGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLPIL 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	CYP6-like	69..500	CDD:410679	129/429 (30%)
CYP3A43	NP_073731.1	cytochrome_P450	67..493	CDD:477761	131/436 (30%)