DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a2 and Cyp3a57

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001093650.1	Gene:	Cyp3a57 / 622127	MGIID:	3646373	Length:	503	Species:	Mus musculus

Alignment Length:	495	Identity:	153/495 - (30%)
Similarity:	263/495 - (53%)	Gaps:	33/495 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YLLIAISSLLAYLYHR-NFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKSGFP 69
            ::|:..|.:..|:|.. :...:.:.|:|...|.||:||::.:...  |..|..|.|.||.|
Mouse    12 WVLLVTSLVFFYIYGTYSHGLFKKLGIPGPKPLPLFGNIINYLDG--MWKFDDDCYKKYGK---- 70

  Fly    70 FVGFYFLHKPAAFIVDTQLAKNILIKD-FSNFADRGQFHNGRDDPLTQHLFNLDGKKWKDMRQRL 133
            ..|||...:|...|:|.::.|.:|:|: :|.|.:|..|  |....|.:.:...:.::||.:|..|
Mouse    71 IWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRRPF--GPVGFLKKSITISEDEEWKRLRTLL 133

  Fly   134 TPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTCAFGIECNT 198
            :|||||.|:|.|||.:.:..:..|:.:..:   .:....:.:|::...::.|||...:.|:..::
Mouse   134 SPTFTSSKLKEMFPIMRQYGDILVRNLRRE---EEKEEPINMKDIFGAYSMDVITGTSCGVNIDS 195

  Fly   199 LRTPVSDFRTMGQKV----FTDMRHGKLLTMFVFSF-PKLASRLRMRMMPEDVHQFFMRLVNDTI 258
            |..|...|....:|:    |.|   ..||::.:|.| ..:...|.:.:.|.....||.:.|....
Mouse   196 LNNPQDPFVQKIKKILKFKFFD---PFLLSVVLFPFLTPIYEMLNLSIFPRQSMNFFKKFVKKMK 257

  Fly   259 ALRERENFK-RNDFMNLLIELK-QKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSY 321
            ..|...|.| |.||:.|::..: .||:      |.::.:...|:|||..:|...|::.:|:::|:
Mouse   258 KDRLDYNQKNRVDFLQLMMNTQNSKGQ------ESLKALSDLEMAAQTLIFIFGGYDGTSTSISF 316

  Fly   322 CLYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALND 386
            .:||||.:.|:|.:|::||...| ..:..:||:::..|.||:.|::|:||||.:|..::|.:..|
Mouse   317 IMYELATHPDVQKKLQDEIDRAL-PNKAPVTYDALMDMEYLDMVVNESLRLYPVVSRIDRFSKKD 380

  Fly   387 YVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNC 451
            ..:.|   :.|.|||.|:||....|||.:.:|.||.|.|||||.|.....:...::|||:|||||
Mouse   381 VEIHG---VFIPKGTIVMIPIYPLHRDPEYWPEPEDFCPERFSKENKGNIDPYIYMPFGNGPRNC 442

  Fly   452 IGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPMSI 491
            |||||..:..::.:..::..|.|..|:.|:||:|.|...|
Mouse   443 IGMRFALISVKLAVTGVLQNFTVQPCEETQIPVKISRQPI 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	147/464 (32%)
Cyp3a57	NP_001093650.1	p450	39..493	CDD:278495	148/468 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.720