DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a2 and CYP4F11

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001122404.1	Gene:	CYP4F11 / 57834	HGNCID:	13265	Length:	524	Species:	Homo sapiens

Alignment Length:	400	Identity:	109/400 - (27%)
Similarity:	197/400 - (49%)	Gaps:	41/400 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 GKKWKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITE--QVPAAQNGAVLEIKELMARFTTD 185
            |.||...|:.|||.|....:|    ..:|:..:.|.::.:  |..|::..|.|::.|.::..|.|
Human   141 GDKWSRHRRMLTPAFHFNILK----PYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLD 201

  Fly   186 VIGTCAFGIECNTLRTPVSDF--RTMGQKVFTDMRHGKLLTMFVFSFPKLASRLRMRMMPEDVHQ 248
            .:..|.|..|.|....| |::  ..:....|.:.|:.::|....|.:.......|.|.....||.
Human   202 SLQKCVFSFESNCQEKP-SEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHD 265

  Fly   249 FFMRLVND---TIALRERENFKRN-------DFMNLLIELKQKGRVTLDNGEVIEGMDIGELAAQ 303
            |...::.:   |:..:..::|.:|       ||:::|:..|.      ::|:.:...||   .|:
Human   266 FTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKD------EDGKELSDEDI---RAE 321

  Fly   304 VFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQEG-QLTYESIKAMTYLNQVIS 367
            ...|...|.:|::|.:|:.||.||::.:.|::.|.|:|.:|:::|. ::.::.:..:.:|...|.
Human   322 ADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIK 386

  Fly   368 ETLRLYTLVPHLERKALNDYVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEK 432
            |:|||:..||.:.|....|:|:|  :..||.||...:|.....|.:..::|:||.:||.||..|.
Human   387 ESLRLHPPVPVISRCCTQDFVLP--DGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQEN 449

  Fly   433 VAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPM---SIVLG 494
            :..|..:.::||..|||||||..|...:.::.||..:..||:       :|....|.   .::|.
Human   450 IKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRI-------LPTHTEPRRKPELILR 507

  Fly   495 TVGGIYLRVE 504
            ..||::||||
Human   508 AEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	105/396 (27%)
CYP4F11	NP_001122404.1	p450	52..506	CDD:365848	102/387 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810