DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a2 and cyp4v7

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001073465.1	Gene:	cyp4v7 / 562008	ZFINID:	ZDB-GENE-061103-88	Length:	510	Species:	Danio rerio

Alignment Length:	549	Identity:	147/549 - (26%)
Similarity:	244/549 - (44%)	Gaps:	98/549 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFVLIYLLIAISSLLAYLYHRNF-NYWNR-RGVPHDA-PHPLYGNMVGFRKNRVMHDFFYDYY-- 60
            :|..:.||:..|:  ||...:|: ..||. |.:|..| .:|:.||.:.|:.|  ..|||....
Zfish    13 LFTAVLLLLLAST--AYNPLKNYIGKWNEMRPIPGMAGAYPIIGNALQFKTN--AGDFFNQIIEG 73

  Fly    61 ---NKYRKSGFPFVGFYFLHKPAAFIVDTQLAKNI-LIKDFSNFADRGQFHNGRDDPLTQHLFNL 121
               |::......:||      |..|:: ...|:|| ::...|...|:...:......|...|...
Zfish    74 TNENRHLPLAKVWVG------PVPFLI-LYHAENIEVVLSNSRHLDKSYSYRFLHPWLGTGLLTS 131

  Fly   122 DGKKWKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVP-AAQNGAVLEIKELMARFTTD 185
            .|:||::.|:.|||||.           ..:..:|::|:.||.. ..|....||..|....|  :
Zfish   132 TGEKWRNRRKMLTPTFH-----------FSILSDFLEVMNEQTDILIQKMQKLEDGEPFNCF--N 183

  Fly   186 VIGTCAFGIECNTLRTPVSDFRTMGQKVFTDMRHGKLLTMFVFSFPKLASRLRMR---MMPEDV- 246
            .|..||..|.|.|         .||:|::............|:....:.:: |.|   :.|:.:
Zfish   184 FITLCALDIICET---------AMGKKIYAQSNADSEYVQSVYKMSDIITK-RQRAPWLWPDWIY 238

  Fly   247 --------HQFFMRLVNDTIA--LRERENF--------------KRNDFMNLLIELKQKGRVTLD 287
                    |...:::::...|  :|||..|              ||..|:::|:      :.|.:
Zfish   239 NKLKEGKEHAKRLKILHSFTANVIRERAEFMSSEPDSDSDQGERKRQAFLDMLL------KTTYE 297

  Fly   288 NGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQEGQLT 352
            ||:.:...||.|   :|..|...|.:|::::|::.|:.:..:.::|..::.|:|.|....|..:.
Zfish   298 NGQKLSHEDIQE---EVDTFMFEGHDTTAASMNWALHLIGSHPEVQKAVQAELQEVFGSSERHVG 359

  Fly   353 YESIKAMTYLNQVISETLRLYTLVPHLERKA-----LNDYVVPGHEKLVIEKGTQVIIPACAYHR 412
            .|.:|.:.||..||.|:||::..||...|..     :|.:.||        ||...:|...|.||
Zfish   360 VEDLKKLRYLECVIKESLRIFPSVPLFARSICEACHINGFKVP--------KGVNAVIIPYALHR 416

  Fly   413 DEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRVSVC 477
            |...:|.||.|.||||.||....|....::||..|||||||.||..|:.::.||.|:..|.|..|
Zfish   417 DPRYFPEPEEFQPERFMPENSKGRHPYAYIPFSAGPRNCIGQRFAMMEEKVVLATILRHFDVEAC 481

  Fly   478 DTTEIPLKYSPM-SIVLGTVGGIYLRVER 505
            .:.|   :..|: .::|....||:::::|
Zfish   482 QSRE---ELRPLGELILRPEKGIWIKLQR 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	134/506 (26%)
cyp4v7	NP_001073465.1	p450	44..505	CDD:278495	136/512 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810