DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a2 and cyp4v8

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001071070.1	Gene:	cyp4v8 / 558851	ZFINID:	ZDB-GENE-061103-601	Length:	513	Species:	Danio rerio

Alignment Length:	557	Identity:	142/557 - (25%)
Similarity:	233/557 - (41%)	Gaps:	122/557 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VLIYLLIAISSLLAYLYHRNFNYWNR-RGVPH-DAPHPLYGNMVGFRKNRVMHDFFYD---YYNK 62
            |:.:..|....|.:||:.     |.. :.:|. ....|..||.:.|:.|   .|||..   |..:
Zfish    19 VICFAYITYQLLKSYLHK-----WKELKPIPGIGNTFPFIGNALQFKSN---GDFFLQLVGYTTE 75

  Fly    63 YRKSGFPFVGFYFLHKPAAFI-------VDTQLAKNILIKDFSNFADRGQFHNGRDDPLTQHLFN 120
            ::.|  |.:..:.  .|..|:       |:|.|...:.|       |:...:......|...|..
Zfish    76 FQNS--PLLKIWI--GPIPFLILFHAETVETVLNNPVHI-------DKAYAYQFLHPWLGTGLLT 129

  Fly   121 LDGKKWKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMAR---- 181
            ..|.||:..|:.|||||.           ..:..||::|:.||..     .::|..|..|.
Zfish   130 STGDKWRRRRKMLTPTFH-----------FSILTEFLEVMNEQAE-----VLIEKLEKQAGKGPF 178

  Fly   182 --FTTDVIGTCAFGIECNTLRTPVSDFRTMGQKVFTDMRHGKLLTMFVFSFPKLASRLRMRM--- 241
              |:.  |..||..|.|.|         .||::::....:.......|:....:.:| |.||
Zfish   179 NCFSH--ITLCALDIICET---------AMGKRIYAQSNYDSEYVRTVYRMSDIITR-RQRMPWY 231

  Fly   242 MPEDV-----------------HQFFMRLVNDTIALRERENF---------------KRNDFMNL 274
            .|:.|                 |.|...::|      ||..:               ||..|:::
Zfish   232 WPDFVYNYVGEGREHNRSLKILHSFTESVIN------ERAEYLSYVESDSESDQGMRKRRAFLDM 290

  Fly   275 LIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNE 339
            |::.|.      ::|:::...||.|   :|..|...|.:|:::.|::.::.|..:.::|.:.:.|
Zfish   291 LLKTKD------EDGKMLTHKDIQE---EVDTFMFEGHDTTAAAMNWAIHLLGSHPEVQRKAQQE 346

  Fly   340 IQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALNDYVVPGHEKLVIEKGTQVI 404
            :..|..|.|..:..|.:|.:.||..||.|:|||:..||...|...:|..:.|.:   :.|||.::
Zfish   347 LFEVFGESERPVNTEDLKKLRYLECVIKESLRLFPSVPFFARTICDDTQINGFK---VPKGTNIV 408

  Fly   405 IPACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQII 469
            :...|.|||...:|:||.|.||||.||....|....::||..|.|||||.||..|:.::.||.|:
Zfish   409 VITYALHRDPRFFPDPEEFRPERFLPENCVGRHPYAYIPFSAGLRNCIGQRFAIMEEKVILAYIL 473

  Fly   470 SRFRVSVCDTTEIPLKYSPM-SIVLGTVGGIYLRVER 505
            ..|.:..|...|   :..|: .:||....||::.:||
Zfish   474 RYFNIVACQKRE---ELRPLGELVLRPEQGIWITLER 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	133/517 (26%)
cyp4v8	NP_001071070.1	p450	44..501	CDD:278495	132/519 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810