Protein Alignment Cyp6a2 and cyp4v2a

DIOPT Version :10

• Sequence 1: NP_523628.1
• Gene: Cyp6a2 / 35587
• FlyBaseID: FBgn0000473
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_001071070.1
• Gene: cyp4v2a / 558851
• ZFINID: ZDB-GENE-061103-601
• Length: 513
• Species: Danio rerio
• Alignment Length: 557
• Identity: 142/557 - (25%)
• Similarity: 233/557 - (41%)
• Gaps: 122/557 - (21%)

  Fly     3 VLIYLLIAISSLLAYLYHRNFNYWNR-RGVPH-DAPHPLYGNMVGFRKNRVMHDFFYD---YYNK 62
            |:.:..|....|.:||:.     |.. :.:|. ....|..||.:.|:.|   .|||..   |..:
Zfish    19 VICFAYITYQLLKSYLHK-----WKELKPIPGIGNTFPFIGNALQFKSN---GDFFLQLVGYTTE 75

  Fly    63 YRKSGFPFVGFYFLHKPAAFI-------VDTQLAKNILIKDFSNFADRGQFHNGRDDPLTQHLFN 120
            ::.|  |.:..:.  .|..|:       |:|.|...:.|       |:...:......|...|..
Zfish    76 FQNS--PLLKIWI--GPIPFLILFHAETVETVLNNPVHI-------DKAYAYQFLHPWLGTGLLT 129

  Fly   121 LDGKKWKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMAR---- 181
            ..|.||:..|:.|||||.           ..:..||::|:.||..     .::|..|..|.
Zfish   130 STGDKWRRRRKMLTPTFH-----------FSILTEFLEVMNEQAE-----VLIEKLEKQAGKGPF 178

  Fly   182 --FTTDVIGTCAFGIECNTLRTPVSDFRTMGQKVFTDMRHGKLLTMFVFSFPKLASRLRMRM--- 241
              |:.  |..||..|.|.|         .||::::....:.......|:....:.:| |.||
Zfish   179 NCFSH--ITLCALDIICET---------AMGKRIYAQSNYDSEYVRTVYRMSDIITR-RQRMPWY 231

  Fly   242 MPEDV-----------------HQFFMRLVNDTIALRERENF---------------KRNDFMNL 274
            .|:.|                 |.|...::|      ||..:               ||..|:::
Zfish   232 WPDFVYNYVGEGREHNRSLKILHSFTESVIN------ERAEYLSYVESDSESDQGMRKRRAFLDM 290

  Fly   275 LIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNE 339
            |::.|.      ::|:::...||.|   :|..|...|.:|:::.|::.::.|..:.::|.:.:.|
Zfish   291 LLKTKD------EDGKMLTHKDIQE---EVDTFMFEGHDTTAAAMNWAIHLLGSHPEVQRKAQQE 346

  Fly   340 IQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALNDYVVPGHEKLVIEKGTQVI 404
            :..|..|.|..:..|.:|.:.||..||.|:|||:..||...|...:|..:.|.:   :.|||.::
Zfish   347 LFEVFGESERPVNTEDLKKLRYLECVIKESLRLFPSVPFFARTICDDTQINGFK---VPKGTNIV 408

  Fly   405 IPACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQII 469
            :...|.|||...:|:||.|.||||.||....|....::||..|.|||||.||..|:.::.||.|:
Zfish   409 VITYALHRDPRFFPDPEEFRPERFLPENCVGRHPYAYIPFSAGLRNCIGQRFAIMEEKVILAYIL 473

  Fly   470 SRFRVSVCDTTEIPLKYSPM-SIVLGTVGGIYLRVER 505
            ..|.:..|...|   :..|: .:||....||::.:||
Zfish   474 RYFNIVACQKRE---ELRPLGELVLRPEQGIWITLER 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	CYP6-like	69..500	CDD:410679	122/479 (25%)
cyp4v2a	NP_001071070.1	cytochrome_P450	68..503	CDD:477761	125/494 (25%)