DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a2 and cyp3c4

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001071016.1	Gene:	cyp3c4 / 558541	ZFINID:	ZDB-GENE-060929-96	Length:	507	Species:	Danio rerio

Alignment Length:	491	Identity:	142/491 - (28%)
Similarity:	252/491 - (51%)	Gaps:	25/491 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FVLIYLLIAISSLLAYLYHRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKS 66
            :.|:.|:|.:..:.....||   ::.:.|:|...|.|..|.::.:.|.  :.:|..:...||.|
Zfish    11 WTLVVLVITLLFIYGVWPHR---FFIKLGIPGPRPWPFVGTLLSYAKG--LCNFDMECAKKYGK- 69

  Fly    67 GFPFVGFYFLHKPAAFIVDTQLAKNILIKD-FSNFADRGQFHNGRDDPLTQHLFNLDGKKWKDMR 130
               ..|.|....|...:.|.::.|.:|:|: :|||.:|.:...|...|.:..:..:..::||.||
Zfish    70 ---VWGIYDGRLPILMVADLEVIKVVLVKECYSNFINRRKRTTGLAGPFSDGIIMVKDERWKRMR 131

  Fly   131 QRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTCAFGIE 195
            ..|:|.||||::|.:||..:..::.|:|.:.::.|...    ::|||::|.::.|||.:.:|.::
Zfish   132 STLSPYFTSGRLKEIFPIAMTHADRFIKNMQKKDPEQP----VKIKEVVAPYSLDVITSSSFSVD 192

  Fly   196 CNTLRTPVSDFRTMGQKVFTDMRHGKLLTMFVFSFPKLA---SRLRMRMMPEDVHQFFMRLVNDT 257
            .:::..|...| .:..|.|........|.:.:..||.||   .::.:.:..:....||..::...
Zfish   193 IDSINNPEDPF-VINVKKFIQFNMFNPLLLLILLFPSLAIPLKKMGVTLFSKSAMDFFYSVLKKI 256

  Fly   258 IALRERENFKRNDFMNLLIELKQKGRVTLDNG---EVIEGMDIGELAAQVFVFYVAGFETSSSTM 319
            .....:|:..|.||:.|:::.:.......|:.   :..:|:...|:.:|..||.:.|:||:|:|:
Zfish   257 KDDHNKESEGRVDFLKLMLQNQIPDDQIQDSDTSEQPAKGLTDHEILSQSLVFILGGYETTSTTL 321

  Fly   320 SYCLYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKAL 384
            ::.||.||.|.|..::|..||.... ..:..:||:::..|.||...|:|::||....|.|||.|.
Zfish   322 TFLLYNLATNPDCLEKLVEEIDKNF-PLDTPITYDALMRMDYLEMAINESMRLLPTAPRLERSAK 385

  Fly   385 NDYVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPR 449
            ...|:.|   |.|.:||.|.||......|.|::.:|..|.|||||||..:......::|||.|||
Zfish   386 KTVVING---LTIPEGTLVGIPTYVLSHDPDIWESPGEFRPERFSPENKSEFLQYAFIPFGLGPR 447

  Fly   450 NCIGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLK 485
            ||||||:..|..::.:.:::..|.|..|..|:|||:
Zfish   448 NCIGMRYAVMIMKLFVVKLLQNFSVETCKETQIPLE 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	135/457 (30%)
cyp3c4	NP_001071016.1	p450	38..485	CDD:278495	136/461 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm6472
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.720