DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a2 and cyp3c2

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	XP_021330384.1	Gene:	cyp3c2 / 558473	ZFINID:	ZDB-GENE-081103-62	Length:	503	Species:	Danio rerio

Alignment Length:	501	Identity:	142/501 - (28%)
Similarity:	254/501 - (50%)	Gaps:	43/501 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YLLIAISSLLAYLY----HRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKS 66
            ::|:.:...|.|:|    |   .::.:.|:|...|.|.:|..:.:.|.  ..:|..:...||.|
Zfish    11 WILVVLVLTLLYMYGVWPH---GFFKKLGIPGPRPWPFFGTFLSYTKG--FFNFDMECAKKYGK- 69

  Fly    67 GFPFVGFYFLHKPAAFIVDTQLAKNILIKD-FSNFADRGQFHNGRDDPLTQHLFNLDGKKWKDMR 130
               ..|.|....|...:.|.::.|.|::|: :|.|.:|.:.:.....||...:..:..::||.:|
Zfish    70 ---VWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREINVDLAGPLADGITAVKDERWKRIR 131

  Fly   131 QRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTCAFGIE 195
            ..|:|.||||::|.:||..:..::.|:|    .:....:...::|||:||.::.||:.:.||.::
Zfish   132 GTLSPYFTSGRLKEIFPIAMTHADRFIK----NMQKGDHEQPVKIKEVMASYSLDVVTSSAFSVD 192

  Fly   196 CNTLRTPVSDFRTMGQKVFTDMRHGKLLTMFVFSFPKLAS---RLRMRMMPEDVHQFFMRLVNDT 257
            .:::..|...|.| ..|.|.......|..:.:..||.:|:   ::.:.|..:....||.:
Zfish   193 IDSINNPDDPFVT-NIKNFLKFNLFGLFVLLLTVFPSIANLLGKMGLSMFSKPTVDFFYK----- 251

  Fly   258 IALRE-RENFK----RNDFMNLLIELK----QKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFE 313
             |||: :|..|    |.||..|:|:.:    |....|.:..|  :|:...|:.:|.|:|.:.|:|
Zfish   252 -ALRKIKEEHKDSNGRVDFFRLMIQNEIPDDQVKDTTSEQPE--KGLTDHEILSQSFIFIMGGYE 313

  Fly   314 TSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPH 378
            |:|:|:::.||.||.|.|..::|..:|.... ..:..::|:::..:.||...|:|::||....|.
Zfish   314 TTSTTLTFLLYNLAINPDCLEKLVEKIDKNF-PLDTPISYDALMKIDYLEMSINESMRLLPTAPR 377

  Fly   379 LERKALNDYVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLP 443
            |||.......:.|   :.|.|.|.:.||....::|..|:.:|..|.|||||||..:......::|
Zfish   378 LERVCKKTVEMNG---ITIPKDTMITIPTYVLNQDPQLWDSPHEFRPERFSPENKSEFLQYAFMP 439

  Fly   444 FGDGPRNCIGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPM 489
            ||.|||||||||:..|..::.:.:::..|.|..|..|:|||:.:|:
Zfish   440 FGLGPRNCIGMRYALMIVKLLVVKLLQNFSVETCKETQIPLELNPV 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	135/467 (29%)
cyp3c2	XP_021330384.1	p450	38..496	CDD:306555	136/471 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910