DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a2 and Cyp3a73

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	XP_038945885.1	Gene:	Cyp3a73 / 498198	RGDID:	1595705	Length:	504	Species:	Rattus norvegicus

Alignment Length:	508	Identity:	160/508 - (31%)
Similarity:	258/508 - (50%)	Gaps:	35/508 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YLLIAISSLLAYLY-HRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKSGFP 69
            :||:||..:|.|.: .|....:.::|:|...|.|..|.::.:.:.....|.     ..|:|.| .
  Rat    12 WLLLAIILVLFYRFGTRTHGIFKKQGIPGPKPLPFLGTVLNYYRGLWKFDM-----ECYKKCG-K 70

  Fly    70 FVGFYFLHKPAAFIVDTQLAKNILIKD-FSNFADRGQFHNGRDDPLTQHLFNLDGKKWKDMRQRL 133
            ..|.:....|...|:||::.|::|:|: ||.|.:|...  |....:::.:.....::||..|..|
  Rat    71 IWGLFDGQTPVFAIMDTEMIKSVLVKECFSVFTNRRNI--GPVGIMSKSISVAKDEEWKRYRAFL 133

  Fly   134 TPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTCAFGIECNT 198
            :||||||::|.|||.:....:..||.:.::|   :.|..|.:||:...::.|||.:.:|.:..|:
  Rat   134 SPTFTSGRLKEMFPIIEHYGDILVKYLKQKV---EKGKPLAMKEVFGAYSMDVITSTSFEVNINS 195

  Fly   199 LRTPVSDFRTMGQKV----FTDMRHGKLLTMFVFSFPKLA---SRLRMRMMPEDVHQFFMRLVND 256
            :..|...|....:|.    |.|.     |.:.|..||.|.   ..|.:.:.|:|...||.:.|..
  Rat   196 INNPKDPFVEKVKKFQRFDFFDP-----LFLSVVLFPFLTPIYEMLNICLFPKDSVAFFQKFVYR 255

  Fly   257 TIALR-ERENFKRNDFMNLLIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMS 320
            ....| :.::..|.||:.|::......:..:.:..:   .|| |:.||..:|..|.:||:|||:|
  Rat   256 MKQTRLDSKHKHRVDFLQLMMNAHNNSKDKVSHKAL---SDI-EIVAQAIIFIFASYETTSSTLS 316

  Fly   321 YCLYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALN 385
            :.||.||.:.|.|.:|:.||...| ..:...||:::..|.||:.|::||.|||.:...|||....
  Rat   317 FVLYSLATHPDSQKKLQEEIDRAL-PNKAPPTYDTVMEMEYLDMVLNETPRLYPIGYRLERVCKK 380

  Fly   386 DYVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRN 450
            |..:.|   :.|.||:.|:||......|...:|.||.|.|||||.|...:.:...:||||:||||
  Rat   381 DIKLDG---VFIPKGSVVMIPFYTLQHDPQHWPEPEEFLPERFSKENKGSIDPYVYLPFGNGPRN 442

  Fly   451 CIGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPMSIVLGTVGGIYLRV 503
            ||||||..|..::.|.:::..|...:|:.|:||||.|...: .|....|.|:|
  Rat   443 CIGMRFALMNMKLALTKVLQNFSFQLCEETQIPLKLSRQRL-FGPEKPIVLKV 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	149/474 (31%)
Cyp3a73	XP_038945885.1	CYP3A	67..493	CDD:410743	144/445 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010