DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a2 and Cyp6a18

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001287562.1	Gene:	Cyp6a18 / 43304	FlyBaseID:	FBgn0039519	Length:	507	Species:	Drosophila melanogaster

Alignment Length:	506	Identity:	270/506 - (53%)
Similarity:	371/506 - (73%)	Gaps:	4/506 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FVLIYLLIAISSLLAYLYHRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKS 66
            :.|..:.:|:.:::.|:.||...|:.|||:|:|.||||.|||.|::|.|.:|:...:||||||.|
  Fly     5 YFLFQVAVALLAIVTYILHRKLTYFKRRGIPYDKPHPLRGNMEGYKKTRTVHEIHQEYYNKYRNS 69

  Fly    67 GFPFVGFYFLHKPAAFIVDTQLAKNILIKDFSNFADRGQFHNGRDDPLTQHLFNLDGKKWKDMRQ 131
            ..||||||...|||||::|.:|||.||||:||||.|:|.::|.:|||::.|||||||.:|:.:|.
  Fly    70 KAPFVGFYLFQKPAAFVIDLELAKQILIKNFSNFTDKGIYYNEKDDPMSAHLFNLDGPQWRLLRS 134

  Fly   132 RLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTCAFGIEC 196
            :|:.||||||||||:|||:.|:|||:.|:.|:|   ...::|::::|:||||.||||||||||:|
  Fly   135 KLSSTFTSGKMKFMYPTVVSVAEEFMAVMHEKV---SENSILDVRDLVARFTVDVIGTCAFGIKC 196

  Fly   197 NTLRTPVSDFRTMGQKVFTDMRHGKLLTMFVFSFPKLASRLRMRMMPEDVHQFFMRLVNDTIALR 261
            |:||...::|...|::...|.|||.|::..:.|:|.||.||.:......:.:|:.|:|.:|:.||
  Fly   197 NSLRDEKAEFLHFGRRALLDSRHGNLVSGLMRSYPNLARRLGLCRNTAQIQEFYQRIVKETVTLR 261

  Fly   262 ERENFKRNDFMNLLIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYCLYEL 326
            |:||.||||||::||.||.:..:||:||||::|:.:.|:.||.|||::|||:||||||.:.||||
  Fly   262 EKENIKRNDFMDMLIGLKNQKNMTLENGEVVKGLTMDEIVAQAFVFFIAGFDTSSSTMGFALYEL 326

  Fly   327 AQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALNDYVVPG 391
            |:|..|||::|.|:..|||:.:.:.|||.||.:.||:|||:||||.||:||:::|.|...:||||
  Fly   327 AKNPSIQDKVRAELGQVLEQHDQKFTYECIKDLKYLDQVINETLRHYTIVPNVDRVAAKRFVVPG 391

  Fly   392 HEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNCIGMRF 456
            :.|.|||.|..||||:.|.|.|..:||.|..|.|||||||:.|.|.||.|||||:|||||||:||
  Fly   392 NPKFVIEAGQSVIIPSSAIHHDPSIYPEPNEFRPERFSPEESAKRPSVAWLPFGEGPRNCIGLRF 456

  Fly   457 GQMQARIGLAQIISRFRVSVCDTTEIPLKYSPMS-IVLGTVGGIYLRVERI 506
            ||||||||||.:|..|..|.|..|..||.:.|.| |:||..|||.|:||.|
  Fly   457 GQMQARIGLAMLIKNFTFSPCSATPDPLTFDPHSAILLGIKGGIQLKVEAI 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	255/466 (55%)
Cyp6a18	NP_001287562.1	p450	38..504	CDD:278495	256/468 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471792
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	1	1.000	-	-		H130979
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	1	0.950	-	0	Normalized mean entropy	S4378
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	13	12.750