DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a2 and Cyp6d5

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_650327.1	Gene:	Cyp6d5 / 41706	FlyBaseID:	FBgn0038194	Length:	508	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	181/515 - (35%)
Similarity:	295/515 - (57%)	Gaps:	30/515 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IYLLIAISSLLAYLYHR-NFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKSGF 68
            ||||||..:|| |:|.: .|:||:|:|.|.......:|.:....|.:  ..|....|:.|:.:..
  Fly     4 IYLLIAAVTLL-YVYLKWTFSYWDRKGFPSTGVSIPFGALESVTKGK--RSFGMAIYDMYKSTKE 65

  Fly    69 PFVGFYFLHKPAAFIVDTQLAKNILIKDFSNFADRGQFHNGRDDPLTQHLFNLDGKKWKDMRQRL 133
            |.:|.|...:||..:.|.|||.::|:|||::|.|||.:.:.::||::..||.::|..|:.:|.:|
  Fly    66 PVIGLYLTLRPALLVRDAQLAHDVLVKDFASFHDRGVYVDEKNDPMSASLFQMEGASWRALRNKL 130

  Fly   134 TPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGA-VLEIKELMARFTTDVIGTCAFGIECN 197
            ||:|||||:|.||.|...|.::.|..|.:|:||  ||| .||:|:|||.:..|:|.|..||::.:
  Fly   131 TPSFTSGKLKAMFETSDSVGDKLVDSIRKQLPA--NGAKELELKKLMATYAIDIIATTIFGLDVD 193

  Fly   198 TLRTPVSDFRTMGQKVFTDMRHGKLLTMFVFSFPKLASRLRMRMMPEDVHQFFMRLVNDTIALRE 262
            :...|.::|:.:.:||..:.....:.....|.:|.|..........::..:....|.|.|:.|||
  Fly   194 SFADPNNEFQIISKKVNRNNIEDIIRGTSSFLYPGLEKFFVKIGWKQEATERMRELSNRTVDLRE 258

  Fly   263 RENFKRNDFMNLLIELKQKGRVTLD----------NGEVIEGMDIGELAAQVFVFYVAGFETSSS 317
            :.|..|.|.:.||::|:.:|::..|          ||  ::.|....:|.|:|:|||||:||::|
  Fly   259 QNNIVRKDLLQLLLQLRNQGKINTDDNIWSAESTKNG--VKSMSKDLIAGQLFLFYVAGYETTAS 321

  Fly   318 TMSYCLYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERK 382
            |.|:.||||.||.::.::.:.::::.:|:..|:|||::|..|.||...|.||.|.|..:|.|.|.
  Fly   322 TTSFTLYELTQNPEVMEKAKEDVRSAIEKHGGKLTYDAISDMKYLEACILETARKYPALPLLNRI 386

  Fly   383 ALNDYVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDG 447
            ...||.|| ..||||:|||.:||.....||||:.:|:|..:.|||:. |.........:||||:|
  Fly   387 CTKDYPVP-DSKLVIQKGTPIIISLIGMHRDEEYFPDPLAYKPERYL-ENGKDYTQAAYLPFGEG 449

  Fly   448 PRNCIGMRFGQMQARIGLAQIISRFRVSV----CDTTEIPLKYSPMSIVLGTVGGIYLRV 503
            ||.|||.|.|::..:|.:|:::|.|.:.:    |:     :::....|.|....|:.:|:
  Fly   450 PRMCIGARMGKVNVKIAIAKVLSNFDLEIRKEKCE-----IEFGVYGIPLMPKSGVPVRL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	164/480 (34%)
Cyp6d5	NP_650327.1	p450	66..478	CDD:278495	155/417 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461173
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900