DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a2 and Cyp9f2

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_650189.1	Gene:	Cyp9f2 / 41520	FlyBaseID:	FBgn0038037	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	169/518 - (32%)
Similarity:	274/518 - (52%)	Gaps:	24/518 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LIYLLIAISSLLAYLYHR----NFNYWNRRGVPHDAPHPLYGNMVG-FRKNRVMHDFFYDYYNKY 63
            :::...|:.::.|.|::|    |.:::..||:.::.|...:|||.| |.:.|.|.|...|.|.|
  Fly     1 MLWEFFALFAIAAALFYRWASANNDFFKDRGIAYEKPVLYFGNMAGMFLRKRAMFDIVCDLYTK- 64

  Fly    64 RKSGFPFVGFYFLHKPAAFIVDTQLAKNILIKDFSNFAD-RGQFHNGRDDP-------LTQHLFN 120
             .....|.|.:...:|...:.|..|.|.|.||||.:|.: |..|....||.       ....||:
  Fly    65 -GGSKKFFGIFEQRQPLLMVRDPDLIKQITIKDFDHFINHRNVFATSSDDDPHDMSNLFGSSLFS 128

  Fly   121 LDGKKWKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTD 185
            :...:|||||..|:|.||..||:.||..:.:|::|.|..:.:.....|... |::|:...|||.|
  Fly   129 MRDARWKDMRSTLSPAFTGSKMRQMFQLMNQVAKEAVDCLKQDDSRVQENE-LDMKDYCTRFTND 192

  Fly   186 VIGTCAFGIECNTLRTPVSDFRTMGQKV--FTDMRHGKLLTMFVFSFPKLASRLRMRMMPEDVHQ 248
            ||.:.|||::.|:.:...:.|..||:|:  ||.::..|.  |..|:...|...|::.:......|
  Fly   193 VIASTAFGLQVNSFKDRENTFYQMGKKLTTFTFLQSMKF--MLFFALKGLNKILKVELFDRKSTQ 255

  Fly   249 FFMRLVNDTIALRERENFKRNDFMNLLIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFE 313
            :|:|||.|.:..|:..|..|.|.:|:|:|.:...:........:......::.||.|||:.||||
  Fly   256 YFVRLVLDAMKYRQEHNIVRPDMINMLMEARGIIQTEKTKASAVREWSDRDIVAQCFVFFFAGFE 320

  Fly   314 TSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQEG-QLTYESIKAMTYLNQVISETLRLYTLVP 377
            ||:..|.:..:||.:|||:|.||..|:|.|.::.|| :||||:|..|.||:||::|.||.:....
  Fly   321 TSAVLMCFTAHELMENQDVQQRLYEEVQQVDQDLEGKELTYEAIMGMKYLDQVVNEVLRKWPAAI 385

  Fly   378 HLERKALND--YVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARESVE 440
            .::|:...|  :.|.| :|:.::||..:.:|.|.:|||...:.||..|||||||.|...:.:...
  Fly   386 AVDRECNKDITFDVDG-QKVEVKKGDVIWLPTCGFHRDPKYFENPMKFDPERFSDENKESIQPFT 449

  Fly   441 WLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPMSIVLGTVGGIYLRV 503
            :.|||.|.|||||.||..::|:..:..::..:|.:....:.|||:.......|...||.::::
  Fly   450 YFPFGLGQRNCIGSRFALLEAKAVIYYLLKDYRFAPAKKSCIPLELITSGFQLSPKGGFWIKL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	162/479 (34%)
Cyp9f2	NP_650189.1	p450	36..510	CDD:278495	162/479 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461233
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800