DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a2 and Cyp12e1

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_650003.4	Gene:	Cyp12e1 / 41272	FlyBaseID:	FBgn0037817	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	503	Identity:	118/503 - (23%)
Similarity:	198/503 - (39%)	Gaps:	113/503 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 DAPHPLYGNMV------GFRKNRVMHDFFYDYYNKYRKSGFPFVGFYFLHKPAAFIVDTQLAKNI 92
            |.|.|....::      |..||..:|:.|.|...:|        |..| ..|:  :..|.|...:
  Fly    40 DIPGPSKLQLIRAFLPGGLYKNLPVHEMFLDMNRQY--------GSIF-RMPS--VAGTDLVLTM 93

  Fly    93 LIKDFS-NFADRGQFHNGRD-------------------DPLTQHLFNLDGKKWKDMRQRLTPTF 137
            ..:|:. .|.:.||:...|.                   |.||..    :|..|..||..:.|..
  Fly    94 NPQDYEVIFRNEGQYPYRRSFEVMDYFKRVHRREVFDGYDGLTSG----NGPAWGKMRTAVNPIL 154

  Fly   138 TSGK-MKFMFPTVIKVSEEFVK-------VITEQVPAAQNGAVLEIKELMARFTTDVIGTCAFGI 194
            ...: .|.....:::||:||::       .:|:::|   :...::|:.|:......|......|:
  Fly   155 LQPRNAKLYMTNLVQVSDEFLERIRIIRDPVTQEMP---DDFAVDIRHLVIESICSVALNTHLGL 216

  Fly   195 --------ECNTLRTPVSDFRTMGQKVFTDMRHGKLLTMFVFSFPKLASRLRMRMMPEDVHQFFM 251
                    :...|...:.|...:|.::.......|.|.|  .:|.||     ||.:.......:.
  Fly   217 LGEQRNNKDIQKLVLALQDVVELGFQLDIMPAFWKYLPM--PNFKKL-----MRSLDTITDFCYF 274

  Fly   252 RLVNDTIALRERENFKRNDFMN-------LLIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYV 309
            .:.|   ||:..|...:...:|       ||.:|.:..|.|    .||..||:          ..
  Fly   275 HIGN---ALKRIEEDAKAGTLNEIGLETSLLEKLARFDRQT----AVIIAMDL----------LF 322

  Fly   310 AGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYT 374
            ||.:.:..|:...|:.|:::.|.|.||..||:.:|..::..||.|:::.:.||...|.|.:|:|.
  Fly   323 AGADPTLVTLGGILFSLSKSPDKQARLLEEIRGILPNKDSSLTIENMRNLPYLRACIKEGIRMYP 387

  Fly   375 LVPHLERKALNDYVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPE--RFSPEKVAARE 437
            :.|...|:..:|.|:.|:.   :..||.|.| |..|.     ..|.|.|.|:  .|.||:....|
  Fly   388 IGPGTLRRMPHDVVLSGYR---VVAGTDVGI-AANYQ-----MANMEQFVPKVREFIPERWLRDE 443

  Fly   438 S-----------VEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRV 474
            |           ..:||||.|||:|.|.|...|...|.:::::..|::
  Fly   444 SNSHLVGETATPFMYLPFGFGPRSCAGKRIVDMMLEIAISRLVRNFKI 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	117/501 (23%)
Cyp12e1	NP_650003.4	p450	63..517	CDD:299894	112/480 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910