DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a2 and Cyp6d2

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_611698.1	Gene:	Cyp6d2 / 37594	FlyBaseID:	FBgn0034756	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	158/511 - (30%)
Similarity:	272/511 - (53%)	Gaps:	37/511 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IYLLIAISSLLAYLYHRNFNYWNRRGVPHDAPHPLYGNM-VGFRKNRVMHDFFYDYYNKYRKSGF 68
            |.|.|.|:.||.....|::.:|.|.||..:.....:|.| ...::.|.:.....|.|.::...
  Fly     4 ILLTILIAGLLYRYVKRHYTHWQRLGVDEEPAKIPFGVMDTVMKQERSLGMALADIYARHEGK-- 66

  Fly    69 PFVGFYFLHKPAAFIVDTQLAKNILIKDFSNFADRGQFHNGRDDPLTQHLFNLDGKKWKDMRQRL 133
             .||.|.|:|.:..|.|.|||:.|:..||::|.|||.:.:...|||:.:||||.|..|:::||:|
  Fly    67 -IVGIYMLNKRSILIRDAQLARQIMTSDFASFHDRGVYVDEDKDPLSANLFNLRGASWRNLRQKL 130

  Fly   134 TPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAV-----LEIKELMARFTTDVIGTCAFG 193
            ||:|:|||:|.||.|:..|.::.|:.:        .||:     :|||::|..:..|:||:..||
  Fly   131 TPSFSSGKIKGMFGTIDDVGDKLVQHL--------EGALDQSDEVEIKDVMTTYAVDIIGSVIFG 187

  Fly   194 IECNTLRTPVSDFRTMGQKVFTDMRHGKLL---TMFVFSFPKLASRLRMRMMPEDVHQFFMRLVN 255
            :|.::.|.|.::||.:......|  ...||   .|.:|..|.:|..:........:......::.
  Fly   188 LEIDSFRNPKNEFREISSSTSRD--ESLLLKIHNMSMFICPPIAKLMNRLGYESRILTSLRDMMK 250

  Fly   256 DTIALRERENFKRNDFMNLLIELKQKGRVTLDNGEV---------IEGMDIGELAAQVFVFYVAG 311
            .||..||..|..|.|.:.|||.|:..|::..|:.:|         ::.|.|.::|||.|:|||||
  Fly   251 RTIEFREEHNVVRKDMLQLLIRLRNTGKIGEDDDQVWDMETAQEQLKSMSIEKIAAQAFLFYVAG 315

  Fly   312 FETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQ----EGQLTYESIKAMTYLNQVISETLRL 372
            .|::::..::.||||:...::....:.|:..||.:.    :.:.|||:::.:.:|:..|.||:|.
  Fly   316 SESTAAASAFTLYELSMYPELLKEAQEEVDAVLMKHNLKPKDRFTYEAVQDLKFLDICIMETIRK 380

  Fly   373 YTLVPHLERKALNDYVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARE 437
            |..:|.|.|:...||.|||... :|.|||.::|......||...:|||..:||.||....: ..:
  Fly   381 YPGLPFLNRECTEDYPVPGTNH-IIAKGTPILISLFGMQRDPVYFPNPNGYDPHRFDSNNM-NYD 443

  Fly   438 SVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPMSIVL 493
            ...::|||:|||:||.:|.|::.:::.:|:|::.|.:......|:..::....:::
  Fly   444 QAAYMPFGEGPRHCIALRMGKVNSKVAVAKILANFDLVQSPRKEVEFRFDAAPVLV 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	147/480 (31%)
Cyp6d2	NP_611698.1	p450	65..506	CDD:278495	142/450 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461161
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900