Protein Alignment Cyp6a2 and Cyp46a1

DIOPT Version :10

• Sequence 1: NP_523628.1
• Gene: Cyp6a2 / 35587
• FlyBaseID: FBgn0000473
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_001386630.1
• Gene: Cyp46a1 / 362782
• RGDID: 1306605
• Length: 500
• Species: Rattus norvegicus
• Alignment Length: 500
• Identity: 122/500 - (24%)
• Similarity: 220/500 - (44%)
• Gaps: 81/500 - (16%)

  Fly     7 LLIAISSLLAYLYHRNFNYWNRRGVPHDAPHPLYGNMVGFRK-----NRVMHDFFYDYYNKYRKS 66
            :|:|......:::.....|.:..|.|.  |..|.|::..|.|     .||:.|.|.|:..||.
  Rat    12 VLLAFGLCCTFVHRARSRYEHIPGPPR--PSFLLGHLPYFWKKDEACGRVLQDVFLDWAKKYG-- 72

  Fly    67 GFPFVGFYFLHKPAAFIVDTQLAKNILIKDFSNFADRGQFHNGRDDPLTQHLF------NLDGKK 125
              |.|.....||.:..:...:..|..|:.  :.:....:.:........:.||      ..|..:
  Rat    73 --PVVRVNVFHKTSVIVTSPESVKKFLMS--TKYNKDSKMYRAIQTVFGERLFGQGLVSECDYGR 133

  Fly   126 WKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTC 190
            |...|:.:...|:...:..:..|..:.:|:.::::..:   |.....:.:::::...|.|::...
  Rat   134 WYKQRRVMDLAFSRSSLVSLMGTFNEKAEQLMEILEAK---ADGQTPVSMQDMLTCATIDILAKA 195

  Fly   191 AFGIECNTL---RTPVSDFRTMGQKVFTDMRHGKLLTMFVFSFPKLASRLRMRMMPEDVHQFFMR 252
            |||:|.:.|   :.|:|    ...||..:.......|:..|...|   |.::|.:.|.:.  .:|
  Rat   196 AFGMETSMLLGAQKPLS----QAVKVMLEGISASRNTLAKFMPGK---RKQLREIRESIR--LLR 251

  Fly   253 LVNDTIALRERENFKRN-----DFMNLLIELK---QKGRVTLDNGEVIEGMDIGELAAQVFV-FY 308
            .|......|.||..||.     |.:..:::.:   |...|.|||                || |:
  Rat   252 QVGKDWVQRRREALKRGEDVPADILTQILKAEEGAQDDEVLLDN----------------FVTFF 300

  Fly   309 VAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLY 373
            :||.|||::.:::.:.||::..:|..||:.|:..|:..:. .|.||.:..:.||:||:.|:||||
  Rat   301 IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKR-HLDYEDLGRLQYLSQVLKESLRLY 364

  Fly   374 TLVPH------LERKALNDYV-VPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPE 431
            .  |.      ||.:.|.|.| |||:        |.::.......|.:..:.:|.||:|:||.|.
  Rat   365 P--PAWGTFRLLEEETLIDGVRVPGN--------TPLLFSTYVMGRMDTYFEDPLTFNPDRFGPG 419

  Fly   432 KVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISR--FRV 474
              |.:....:.||..|.|:|||.:|.||:.::.:|:::.|  ||:
  Rat   420 --APKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRL 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	CYP6-like	69..500	CDD:410679	105/432 (24%)
Cyp46a1	NP_001386630.1	CYP46A1-like	61..484	CDD:410706	110/448 (25%)