DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a2 and Cyp9b2

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	496	Identity:	149/496 - (30%)
Similarity:	249/496 - (50%)	Gaps:	39/496 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LIYLLIAISSLLAYLYHR----NFNYWNRRGVPHDAPHPLYGNM--VGFRKNRVMHDFFYDYYNK 62
            ||.:.:|: .::.||.::    .|..:..|.:..:.|:|..|||  ...:|:..... ..::|.:
  Fly     3 LIEICLAL-VVIGYLIYKWSTATFKTFEERKLYFEKPYPFVGNMAAAALQKSSFQRQ-LTEFYER 65

  Fly    63 YRKSGFPFVGFYFLHKPAAFIVDTQLAKNILIKDFSNFADRGQFHNGRDDPLTQHLFNLDGKKWK 127
            .|:  ...|||:.:..|...:.|.:|.|.:.:|||.:|.:...|....|......|..:..::||
  Fly    66 TRQ--HKLVGFFNMRTPMITLNDPELIKKVCVKDFDHFPNHQPFITSNDRLFNDMLSVMRDQRWK 128

  Fly   128 DMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVI------TEQVPAAQNGAVLEIKELMARFTTDV 186
            .||..|||.||:.||:.||..   ::|.|.:.:      ::.:| .:.|..:::|.:..:.:.|:
  Fly   129 HMRNTLTPVFTAAKMRNMFTL---MNESFAECLQHLDSSSKTLP-GRKGFEVDMKVMCNKLSNDI 189

  Fly   187 IGTCAFGIECNTLRTPVSDFRTMGQK-VFTDMRHGKLLTMFVFS--FPKLASRLRMRMMPEDVHQ 248
            |.|.|||::.|:...|.::|..:||. ||:   .|.....|:.|  .|||.|.|::.:.......
  Fly   190 IATTAFGLKVNSYDNPKNEFYEIGQSLVFS---RGLQFFKFMLSTLVPKLFSLLKLTIFDSAKVD 251

  Fly   249 FFMRLVNDTIALRERENFKRNDFMNLLIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFE 313
            :|.|||.:.:..||:.|..|.|.:.||:|.|.:......:.|::         ||.|:|:.|.||
  Fly   252 YFARLVVEAMQYREKHNITRPDMIQLLMEAKNESEDKWTDDEIV---------AQCFIFFFAAFE 307

  Fly   314 TSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQEG-QLTYESIKAMTYLNQVISETLRLYTLVP 377
            .:|:.:....|||..|.|:|:||..||....:...| .|||::::.|||::.||||:||.:||..
  Fly   308 NNSNLICTTTYELLYNPDVQERLYEEIVETKKALNGAPLTYDAVQKMTYMDMVISESLRKWTLAA 372

  Fly   378 HLERKALNDYVV---PGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARESV 439
            ..:|....||.:   .|.:....:.|.::.||....|.|:..:|.|..|||:|||.|:.......
  Fly   373 ATDRLCSKDYTLTDDDGTKLFDFKVGDRINIPISGLHLDDRYFPEPRKFDPDRFSEERKGDMVPY 437

  Fly   440 EWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRVSVCDTT 480
            .:||||.|||||||.|:..||.:..|..::..:::.....|
  Fly   438 TYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHYKIEASPRT 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	142/460 (31%)
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	141/459 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461257
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.800