DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a2 and Cyp4e3

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_523527.1	Gene:	Cyp4e3 / 34291	FlyBaseID:	FBgn0015035	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	563	Identity:	132/563 - (23%)
Similarity:	239/563 - (42%)	Gaps:	102/563 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFVLIYLLIAISSLLAYLYHRNFNYWNRRGVPHD----APHPLYGNMVGFRKN--RVMHDFFYDY 59
            |::.:..|:.:..:....:.|..:  .||.:..:    .|.|:.||.....||  .::..|| |:
  Fly     1 MWLAVLALLVLPLITLVYFERKAS--QRRQLLKEFNGPTPVPILGNANRIGKNPAEILSTFF-DW 62

  Fly    60 YNKYRKSGFPFVGFYFLH------KPAAFIVDT-QLAKNILIKDFSNFADRGQFHNGRDDPLTQH 117
            :..|.|..|.|...|..|      |...:|::: ||.:...|.|..:             |...|
  Fly    63 WYDYGKDNFLFWIGYSSHIVMTNPKQLEYILNSQQLIQKSTIYDLLH-------------PWLGH 114

  Fly   118 -LFNLDGKKWKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMAR 181
             |....|.||...|:.:||:|....::.....   ::|...|.:|:...|:....:::.:|....
  Fly   115 GLLTSFGSKWHKHRKMITPSFHFNILQDFHEV---MNENSAKFMTQLKKASAGDTIIDFQEHANY 176

  Fly   182 FTTDVIGTCAFGIECNTLRTPVSDFRTMGQKVFTDMRHGKLLTMFVFSFPKLASRLRMRMMPE-D 245
            .|.|||...|.|:..|.:....|..    .:.|.||.:.  :.|..|...|.::|: ..:.|| .
  Fly   177 LTLDVICDTAMGVPINAMEQRDSSI----VQAFRDMCYN--INMRAFHPFKRSNRV-FSLTPEFS 234

  Fly   246 VHQFFMRLVND-TIALRERENF-----------------KRNDFMNLLIELKQKGRVTLDNGEVI 292
            .:|..::.:.| |..:.|:..:                 |:..|::.|:.....|| .|...|:.
  Fly   235 AYQKTLKTLQDFTYDIIEKRVYALQNGGSKEDHDPSLPRKKMAFLDTLLSSTIDGR-PLTRQEIY 298

  Fly   293 EGMDIGELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRL-RNEIQTVLEEQEGQLTYESI 356
            |         :|..|...|.:|::|.:|:.:|.|:::.|:|.:| |.:.:.:..:....::::.|
  Fly   299 E---------EVSTFMFEGHDTTTSGVSFSVYLLSRHPDVQRKLYREQCEVMGHDMNRSVSFQEI 354

  Fly   357 KAMTYLNQVISETLRLYTLVPHLERKALNDYVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPE 421
            ..|.||:..|.|..|:|..||.:.|....||.:.|.   ::.|||.:.:.......::.::.:|.
  Fly   355 AKMKYLDLFIKEAQRVYPSVPFIGRYCDKDYDINGS---IVPKGTTLNLALILLGYNDRIFKDPH 416

  Fly   422 TFDPERFSPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRV-----SVCDT-- 479
            .|.||||..||.|   ..|:|||..|||||||.:|..::.:..:::::..|.|     .:..|
  Fly   417 HFRPERFEEEKPA---PFEYLPFSAGPRNCIGQKFALLELKTVISKVVRSFEVLPAVDELVSTDG 478

  Fly   480 ---TEIPL-------------KYSPM---SIVLGTVGGIYLRV 503
               |.:.|             ||.|:   .:.|.:..|::||:
  Fly   479 RLNTYLGLAPDEKLKREAGRHKYDPILSAVLTLKSDNGLHLRL 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	125/521 (24%)
Cyp4e3	NP_523527.1	p450	35..468	CDD:278495	117/472 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810