Protein Alignment Cyp6a2 and Cyp3a44

DIOPT Version :10

• Sequence 1: NP_523628.1
• Gene: Cyp6a2 / 35587
• FlyBaseID: FBgn0000473
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_796354.1
• Gene: Cyp3a44 / 337924
• MGIID: 2449818
• Length: 504
• Species: Mus musculus
• Alignment Length: 492
• Identity: 164/492 - (33%)
• Similarity: 257/492 - (52%)
• Gaps: 26/492 - (5%)

  Fly     7 LLIAISSLLAYLY-HRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKSGFPF 70
            :|:||..:|.|.| .|....:.::|:|...|.|..|.::.:...  :..|..:.|.||.|:...|
Mouse    13 VLLAIILVLLYRYGTRTHGLFKKQGIPGPKPLPFLGTVLNYYTG--IWKFDMECYEKYGKTWGLF 75

  Fly    71 VGFYFLHKPAAFIVDTQLAKNILIKD-FSNFADRGQFHNGRDDPLTQHLFNLDGKKWKDMRQRLT 134
            .|    ..|...|.|.:..||:|:|| .|.|.:|.:|  |....:::.:.....::||..|..|:
Mouse    76 DG----QTPLLVITDPETIKNVLVKDCLSVFTNRREF--GPVGIMSKAISISKDEEWKRYRALLS 134

  Fly   135 PTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTCAFGIECNTL 199
            ||||||::|.|||.:.:..:..||.:.::   |:.|..:.:|:::..::.|||.:.:||:..::|
Mouse   135 PTFTSGRLKEMFPVIEQYGDILVKYLRQE---AEKGMPVAMKDVLGAYSMDVITSTSFGVNVDSL 196

  Fly   200 RTPVSDFRTMGQKVFTDMRHGKLLTMFVFSFPKLA---SRLRMRMMPEDVHQFFMRLVNDTIALR 261
            ..|...|....:| |..:.....|...|..||.|.   ..|.:.|.|.|..:||.:.|:.....|
Mouse   197 NNPEDPFVEEAKK-FLRVDFFDPLLFSVVLFPLLTPVYEMLNICMFPNDSIEFFKKFVDRMQESR 260

  Fly   262 ERENFK-RNDFMNLLIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYCLYE 325
            ...|.| |.||:.|::......: ..|:.:....|   |:..|..:|..||:||:|||:|:.||.
Mouse   261 LDSNQKHRVDFLQLMMNSHNNSK-DKDSHKAFSNM---EITVQSIIFISAGYETTSSTLSFTLYC 321

  Fly   326 LAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALNDYVVP 390
            ||.:.|||.:|:.||...| ..:...|.:::..|.||:.|::||||||.:|..|||....|..:.
Mouse   322 LATHPDIQKKLQAEIDKAL-PNKATPTCDTVMEMEYLDMVLNETLRLYPIVTRLERVCKKDVELN 385

  Fly   391 GHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNCIGMR 455
            |   :.|.||:.|:||:.|.|.|...:|:||.|.|||||.|...:.:...:||||.|||||||||
Mouse   386 G---VYIPKGSMVMIPSYALHHDPQHWPDPEEFQPERFSKENKGSIDPYVYLPFGIGPRNCIGMR 447

  Fly   456 FGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPMSIV 492
            |..|..::.:.:::..|....|..|:||||.|...|:
Mouse   448 FALMNMKLAVTKVLQNFSFQPCQETQIPLKLSRQGIL 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	CYP6-like	69..500	CDD:410679	147/429 (34%)
Cyp3a44	NP_796354.1	CYP3A	67..493	CDD:410743	150/436 (34%)