DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a2 and Cyp28d2

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_608911.1	Gene:	Cyp28d2 / 33748	FlyBaseID:	FBgn0031688	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	523	Identity:	138/523 - (26%)
Similarity:	242/523 - (46%)	Gaps:	54/523 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VLIYLLIAISSL-LAYLYHR-NFNYWNRRGVPHDAPHPLYGNM--VGFRKNRVMHDFFYDYYNKY 63
            |..:|::.::.| |.|::.. |||||.:||:......|..|:.  :..||..:.:| ..|.|.||
  Fly     4 VTTFLVLVLTLLVLVYVFLTWNFNYWRKRGIKTAPTWPFVGSFPSIFTRKRNIAYD-IDDIYEKY 67

  Fly    64 RKSGFPFVGFYFLHKPAAFIVDTQLAKNILIKDFSNFADR--GQFHNGRDDP-LTQHLFNLDGKK 125
            :.:. ..||.:....|...::..:....|...||.:|.:.  ..|.|.:.|. |..:.|.|.|.:
  Fly    68 KDTD-NMVGVFTTRVPQLLVMCPEYIHKIYATDFRSFHNNEWRNFVNKKTDMILGNNPFVLTGDE 131

  Fly   126 WKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTC 190
            ||:.|..:.|..:..::|.::|....|.::||:.|..|...|.:.. |:..:|...:||:|:..|
  Fly   132 WKERRSEIMPALSPNRVKAVYPVSQSVCKKFVEYIRRQQQMATSEG-LDAMDLSLCYTTEVVSDC 195

  Fly   191 AFGIECNTLRTPVSDFRTMGQKVFTDMRHGKLLTMFVFSFPKLASRLRMRM-----MP---EDVH 247
            ..|:...:.....:....|.::||.        |.|.|.|..:.:.|..::     :|   ::..
  Fly   196 GLGVSAQSFTDTPTPLLKMIKRVFN--------TSFEFIFYSVVTNLWQKVRKFYSVPFFNKETE 252

  Fly   248 QFFMRLVNDTIALR-ERENFKRNDFMNLLIELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAG 311
            .||:.::...|.|| |:...:|:||:|.:::|::|           :|:....:......|.:.|
  Fly   253 VFFLDIIRRCITLRLEKPEQQRDDFLNYMLQLQEK-----------KGLHTDNILINTMTFILDG 306

  Fly   312 FETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLV 376
            |||::..:::.:..|.:|.:.||::|.||.:      ..||::.:..:.:|:..|.|||||::
  Fly   307 FETTALVLAHIMLMLGRNPEEQDKVRKEIGS------ADLTFDQMSELPHLDACIYETLRLFS-- 363

  Fly   377 PHLERKAL----NDYVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVAARE 437
            |.:..:.|    .::.......:.::.|..|.||..|.|.|...|.:|.||.||||........:
  Fly   364 PQVAARKLVTEPFEFANKNGRTVHLKPGDVVTIPVKALHHDPQYYEDPLTFKPERFLESNGGGMK 428

  Fly   438 SVE----WLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPMSIVLGTVGG 498
            |..    :|.||||||:|.||||...|.:..|.:|:..|.:.|...|....:......:....||
  Fly   429 SYRDRGVYLAFGDGPRHCPGMRFALTQLKAALVEILRNFEIKVNPKTRSDNQIDDTFFMATLKGG 493

  Fly   499 IYL 501
            |||
  Fly   494 IYL 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	126/488 (26%)
Cyp28d2	NP_608911.1	p450	38..475	CDD:299894	120/466 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460957
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	7.900