DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a2 and Cyp311a1

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_572780.3	Gene:	Cyp311a1 / 32170	FlyBaseID:	FBgn0030367	Length:	483	Species:	Drosophila melanogaster

Alignment Length:	510	Identity:	121/510 - (23%)
Similarity:	196/510 - (38%)	Gaps:	120/510 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PLYGN--MVGFRKNRVMHDFFYDYYNK----YRKSGFPFVGFYF---------LHKPAAFIVDTQ 87
            ||.||  |||..:...:...|.:..::    ||....|.:..:.         ||.|.....||.
  Fly    36 PLLGNAQMVGKLRPEYIFLVFTELRDRFGATYRLRLGPQLWVFLHSAEETRQALHDPTLRKADTF 100

  Fly    88 LAKNILIKDFSNFADRGQFHNGRDDPLTQHLFNLDGKKWKDMRQRLTPTFTSGKMKFMFPTVIKV 152
            :....||            .||.   |..|     |..|...|:.|||.|....::...|.:...
  Fly   101 MQLEPLI------------GNGL---LISH-----GAHWTRQRRLLTPAFQPQLLRSFAPAIGGH 145

  Fly   153 SEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVIGTCAFGIECNTLRTPVSDFRTMGQKVFTDM 217
            .|..|..:     .|..||.||:.|.:.....|.|...:.|.:.:|                ..:
  Fly   146 VERLVGRL-----GATRGAFLEVTEPLFACLLDAIVDTSMGAQLDT----------------QSV 189

  Fly   218 RHGKLLTMFVFSFPKLASRLRMRMMPEDVHQFFMRLVN-----DTIALRERENFKRNDFMNLLIE 277
            .|..::..|     .|:|:|           .|.|::|     |.|       |:|......|.|
  Fly   190 DHSPIIQAF-----HLSSKL-----------LFKRMINPLLSSDWI-------FQRTQLWRDLDE 231

  Fly   278 ------------LKQKGRVTLDNGE---------------VIEGMDIG--ELAAQVFVFYVAGFE 313
                        ::::.:..||.||               ..||..:.  |:..::..|..||.:
  Fly   232 QLQVIHSQMESVIEKRAKELLDMGEPAGRAHNLLDTLLLAKFEGQSLSRREIRDEINTFVFAGVD 296

  Fly   314 TSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPH 378
            |:::.||:.||.||:..:.|.|||.|:|.|..::...|  :::..:.||..:|.|.|||||:||.
  Fly   297 TTTAAMSFVLYALAKFPETQTRLRKELQDVALDETTDL--DALNGLPYLEALIKEVLRLYTIVPT 359

  Fly   379 LERKALNDYVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSPEKVA-ARESVEWL 442
            ..|:......:.|.....   |..:.|.......|::.||:|..|.|||:.||..| |..:..::
  Fly   360 TGRQTTQSTEIGGRTYCA---GVTLWINMYGLAHDKEYYPDPYAFKPERWLPEDGAVAPPAFSYI 421

  Fly   443 PFGDGPRNCIGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPMSIVLGTVG 497
            ||..||..|||.|:..:..::..|:::..|::.: ...:.||:.....::....|
  Fly   422 PFSGGPHVCIGRRYSLLLMKLLTARLVREFQMEL-SPEQAPLRLEAQMVLKAQQG 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	121/510 (24%)
Cyp311a1	NP_572780.3	p450	30..480	CDD:278495	121/510 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910