DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a2 and Cyp4f39

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	XP_006241152.1	Gene:	Cyp4f39 / 299566	RGDID:	1308796	Length:	550	Species:	Rattus norvegicus

Alignment Length:	545	Identity:	130/545 - (23%)
Similarity:	227/545 - (41%)	Gaps:	88/545 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VLIYLLIAISSLL--AYLYHRNFNYWNRRGVPHDAP---HPLYGNMVGFRKNR-----------V 51
            :|::||..:..||  |:....:|....||......|   |.|.|:|..:..|.           .
  Rat    27 LLLFLLFLLFRLLLQAFKLFSDFRITCRRLSCFPEPPGRHWLLGHMSMYLPNEKGLQNEKKVLDT 91

  Fly    52 MHDFFYDYYNKYRKSGFPFVGFYFLHKPAAFIVDTQLAKNILIKDFSNFADRGQFHNGRDDP-LT 115
            ||.....:..       ||:       |...:|.....|.:|... :..|.:.:|......| |.
  Rat    92 MHHIILAWVG-------PFL-------PLLVLVHPDYIKPVLGAS-AAIAPKDEFFYSFLKPWLG 141

  Fly   116 QHLFNLDGKKWKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQ--------NGAV 172
            ..|....|.||...|:.|||.|.           ..:.:.::|:..:.|....        .|:|
  Rat   142 DGLLISKGNKWSRHRRLLTPAFH-----------FDILKPYMKIFNQSVNIMHAKWRRHLAEGSV 195

  Fly   173 --LEIKELMARFTTDVIGTCAFGI--ECNTLRTPVSDF--RTMGQKVFTDMRHGKLLTMFVFSFP 231
              .::.|.::..|.|.:..|.|..  :|   :..:||:  ..:........|..:|.....|.:.
  Rat   196 TSFDMFEHVSLMTLDSLQKCVFSYSSDC---QEKLSDYISSIIELSALVVRRQYRLHHYLDFIYY 257

  Fly   232 KLASRLRMRMMPEDVHQFFMRLVND-TIALRE--------RENFKRNDFMNLLIELKQKGRVTLD 287
            ..|...|.|...:.||.|...::.. ..||||        .:..|..||:::|:..|.:
  Rat   258 LTADGRRFRQACDTVHNFTTEVIQQRRRALRELGAEAWLKAKQGKTLDFIDVLLLAKDE------ 316

  Fly   288 NGEVIEGMDIG--ELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQE-G 349
                 ||.::.  ::.|:...|...|.:|:||.:|:.|:.||:..:.||:.|.|||.|::.:| .
  Rat   317 -----EGKELSDEDIRAEADTFMFEGHDTTSSGLSWALFNLAKYPEYQDKCREEIQEVMKGRELE 376

  Fly   350 QLTYESIKAMTYLNQVISETLRLYTLVPHLERKALNDYVVPGHEKLVIEKGTQVIIPACAYHRDE 414
            :|.::.:..:.:....|.|:||.:..|..:.|:...|..:|  :..:|.||...::.....|.:.
  Rat   377 ELDWDDLTQLPFTTMCIKESLRQFPPVTLISRRCTEDIKLP--DGRIIPKGIICLVSIYGTHYNP 439

  Fly   415 DLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRVSVCDT 479
            .::|:.:.::|.||.|:....|..:.::||..|||||||..|...:.|:.:|..:.|||:||..|
  Rat   440 LVWPDSKVYNPYRFDPDIPQQRSPLAFVPFSAGPRNCIGQSFAMAEMRVVVALTLLRFRLSVDRT 504

  Fly   480 TEIPLKYSPMSIVLGTVGGIYLRVE 504
            .::..|   ..::|.|..|::|.||
  Rat   505 RKVRRK---PELILRTENGLWLNVE 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	118/506 (23%)
Cyp4f39	XP_006241152.1	CYP4F	82..523	CDD:410772	112/485 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900