DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a2 and Cyp4a3

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	XP_038965516.1	Gene:	Cyp4a3 / 298423	RGDID:	631356	Length:	511	Species:	Rattus norvegicus

Alignment Length:	557	Identity:	140/557 - (25%)
Similarity:	238/557 - (42%)	Gaps:	121/557 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FVLIYLLIAISSLLAYLYHRNFNYWNRRGV---PHDAPHPLYGNMVGFRKNRVMHDF----FYDY 59
            |:|...|:...::..||..:    |..:.:   |....|.|:|           ||.    |...
  Rat    23 FLLSLFLVLFKAVQFYLRRQ----WLLKALEKFPSTPSHWLWG-----------HDLKDREFQQV 72

  Fly    60 YNKYRKSGFPFVGFYFL--HKPAAFIVDTQLAKNILIKDFSNFADRGQFHNGRDDPLTQHLFN-- 120
            .....|  ||.....:|  .|....:.|....|.:|               ||.||....::.
  Rat    73 LTWVEK--FPGACLQWLSGSKTRVLLYDPDYVKVVL---------------GRSDPKASGIYQFL 120

  Fly   121 --------------LDGKKWKDMRQRLTPTFTSG----KMKFMFPTVIKVSEEFVKVITEQVPAA 167
                          |:||||....:.|||.|..|    .:|.|..:|..:.:::.|:..:..|
  Rat   121 APWIVSGTGYGLLLLNGKKWFQHWRMLTPAFHYGILKPYVKIMADSVSIMLDKWEKLDDQDHP-- 183

  Fly   168 QNGAVLEIKELMARFTTDVIGTCAFG------IECNTLRTPVSDFRTMGQKVFTDMR---HGKLL 223
                 |||...::..|.|.:..|||.      ::.|: |:.......:....|..:|   :|..:
  Rat   184 -----LEIFHYVSLMTLDTVMKCAFSHQGSVQLDVNS-RSYTKAVEDLNNLTFFRVRSAFYGNSI 242

  Fly   224 TMFVFSFPKLASR------------LRMRMMPEDVHQFFMRLVNDTIALRERENFKRN-DFMNLL 275
            ...:.|..:|:.|            ::||.         .:|.|:....:.|:  ||: ||:::|
  Rat   243 IYNMSSDGRLSRRACQIAHEHTDGVIKMRK---------AQLQNEEELQKARK--KRHLDFLDIL 296

  Fly   276 IELKQKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEI 340
            :..|      :::|:.:...|   |.|:|..|...|.:|::|.:|:..|.||.:.:.|:|.|.|:
  Rat   297 LFAK------MEDGKSLSDED---LRAEVDTFMFEGHDTTASGISWVFYALATHPEHQERCREEV 352

  Fly   341 QTVLEEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALNDYVVPGHEKLVIEKGTQVII 405
            |::|.:.. .:|::.:..::|....|.|.||||..||.:.|:..:....|....  |.||....|
  Rat   353 QSILGDGT-SVTWDHLDQISYTTMCIKEALRLYPPVPSVSRELSSPVTFPDGRS--IPKGITTTI 414

  Fly   406 PACAYHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIIS 470
            .....|.:...:|||:.|||.||||:  :.|.|..:|||..|.|||||.:|...:.::.:|..:.
  Rat   415 LIYGLHHNPSYWPNPKVFDPSRFSPD--SPRHSHAYLPFSGGARNCIGKQFAMNELKVAVALTLL 477

  Fly   471 RFRVSVCDTTEIPLKYSPMS-IVLGTVGGIYLRVERI 506
            ||.: :.|.|.||:   ||: :||.:..||:||::::
  Rat   478 RFEL-LPDPTRIPV---PMARLVLKSKNGIHLRLKKL 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	131/514 (25%)
Cyp4a3	XP_038965516.1	CYP4B-like	69..506	CDD:410771	126/490 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900