DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a2 and Cyp4f18

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001028858.2	Gene:	Cyp4f18 / 290623	RGDID:	1305261	Length:	524	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	133/532 - (25%)
Similarity:	230/532 - (43%)	Gaps:	65/532 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LIYLLIAISSLLAYLYHRNFNYWNRRGVPHDAPHP-----LYGNMVGFRKNRVMHDFFYDYYNKY 63
            |:.||:..|.||||:..:.:..:.........|.|     |:|::...:.:.....:.......:
  Rat    20 LLLLLVGASCLLAYILPQVYAVFENSRRLRRFPQPPTRNWLFGHLGLIQSSEEGLLYIQSLSRTF 84

  Fly    64 RKSGFPFVGFYFLHKPAAFIVDTQLAKNILIKDFSNFADRGQFHNGRDDPLTQHLFNLDGKKWKD 128
            |.....:||.:   .|...|......|.:::...|.......|:......|...|....|.||..
  Rat    85 RDVCCWWVGPW---HPVIRIFHPAFIKPVILAPASVAPKDRVFYRFLKPWLGDGLLLSTGDKWSR 146

  Fly   129 MRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITE---------QVPAAQNGAVLEIKELMARFTT 184
            .|..|||.|.           ..:.:.:||:..:         |..|:|..|.|::.|.::..|.
  Rat   147 HRHMLTPAFH-----------FNILKPYVKIFNDSTNIMHAKWQRLASQGSARLDMFEHISLMTL 200

  Fly   185 DVIGTCAFGIECNTLRTPVSDFRT--MGQKVFTDMRHGKLLTMFVFSFPKLA-SRLRMRMMPEDV 246
            |.:..|.|..:.|....| |::.|  :........||..|| ::|..|..|. ..:|.|.....|
  Rat   201 DSLQKCVFSFDSNCQEKP-SEYITAILELSALVARRHQSLL-LYVDLFYHLTRDGMRFRKACRLV 263

  Fly   247 HQFFMRLVND---TI-------ALRERENFKRNDFMNLLIELKQKGRVTLDNGEVIEGMDIGELA 301
            |.|...::.:   |:       ||:.:...|..||:::|:..|.      ::||.:...||   .
  Rat   264 HDFTDAVIRERRRTLPDQGGDDALKAKAKAKTLDFIDVLLLSKD------EHGEALSDEDI---R 319

  Fly   302 AQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQE-GQLTYESIKAMTYLNQV 365
            |:...|...|.:|::|.:|:.||.||::.:.|:|.|.|::.:|.::| .::.::.:..:.:|...
  Rat   320 AEADTFMFGGHDTTASGLSWILYNLAKHPEYQERCRQEVRELLRDREPEEIEWDDLAQLPFLTMC 384

  Fly   366 ISETLRLYTLVPHLERKALNDYVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERFSP 430
            |.|:|||:.....:.|....|.::|  :..||.||....|.....|.:..::|:||.::|.||..
  Rat   385 IKESLRLHPPATAISRCCTQDIMLP--DGRVIPKGVICRISIFGTHHNPAVWPDPEVYNPFRFDA 447

  Fly   431 EKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPM---SIV 492
            :....|..:.::||..|||||||..|...:.::.||..:.||||       :|....|.   .::
  Rat   448 DNGEGRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRV-------LPDDKEPRRKPELI 505

  Fly   493 LGTVGGIYLRVE 504
            |...||::||||
  Rat   506 LRAEGGLWLRVE 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	121/496 (24%)
Cyp4f18	NP_001028858.2	CYP4F	74..515	CDD:410772	117/474 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900