DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6a2 and CYP4V2

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_997235.3	Gene:	CYP4V2 / 285440	HGNCID:	23198	Length:	525	Species:	Homo sapiens

Alignment Length:	546	Identity:	145/546 - (26%)
Similarity:	232/546 - (42%)	Gaps:	95/546 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLIAISSLLAYLYHRNFNY---WNR-RGVPHDA-PHPLYGNMVGFRKNRVMHDFF---YDYYNKY 63
            |.:|.:||:..|..|..:|   |.: |.:|..| .:||.|:.:..:.:.  .:||   .:|..:|
Human    22 LSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHALLMKPDG--REFFQQIIEYTEEY 84

  Fly    64 RKSGFPFVGFYFLHKPAAFIVDTQLAKNILIKDFSNFADRGQFHNGRDDPLTQHLFNLDGKKWKD 128
            |.  .|.:..:....|...:.:.:..:.||..  |...|:...:...:..|...|....|.||:.
Human    85 RH--MPLLKLWVGPVPMVALYNAENVEVILTS--SKQIDKSSMYKFLEPWLGLGLLTSTGNKWRS 145

  Fly   129 MRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDV------I 187
            .|:.|||||.           ..:.|:|:.::.||       |.:.:|:|......:.      |
Human   146 RRKMLTPTFH-----------FTILEDFLDIMNEQ-------ANILVKKLEKHINQEAFNCFFYI 192

  Fly   188 GTCAFGIECNTLRTPVSDFRTMGQKVFTDMRHGKLLTMFVFSFPKLA-SRLRMRMMPEDV----- 246
            ..||..|.|.|         .||:.:.............|:...::. .|::|..:..|:
Human   193 TLCALDIICET---------AMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMF 248

  Fly   247 -----H----QFFMRLVNDTIALRERE-----------------NFKRNDFMNLLIELKQKGRVT 285
                 |    |......|..||.|..|                 ..||..|::||:.      ||
Human   249 KEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLS------VT 307

  Fly   286 LDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQEGQ 350
            .|.|..:...||.|   :|..|...|.:|:::.:::.||.|..|.::|.::.:|:..|..:.:..
Human   308 DDEGNRLSHEDIRE---EVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRP 369

  Fly   351 LTYESIKAMTYLNQVISETLRLYTLVPHLERKALNDYVVPGHEKLVIEKGTQVIIPACAYHRDED 415
            .|.|.:|.:.||..||.|||||:..||...|....|..|.|:..|   |||:.:|...|.|||..
Human   370 ATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVL---KGTEAVIIPYALHRDPR 431

  Fly   416 LYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRV-SVCDT 479
            .:||||.|.||||.||....|....::||..|||||||.:|..|:.:..|:.|:..|.: |....
Human   432 YFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKR 496

  Fly   480 TEIPLKYSPMSIVLGTVGGIYLRVER 505
            .|:.|:   ..::|....||:::::|
Human   497 EELGLE---GQLILRPSNGIWIKLKR 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	133/507 (26%)
CYP4V2	NP_997235.3	p450	55..517	CDD:278495	133/509 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810