DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6a2 and CYP4A22

DIOPT Version :9

Sequence 1:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001010969.2	Gene:	CYP4A22 / 284541	HGNCID:	20575	Length:	519	Species:	Homo sapiens

Alignment Length:	542	Identity:	148/542 - (27%)
Similarity:	239/542 - (44%)	Gaps:	94/542 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VLIYLLIAISSLLAYLYHRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKSG 67
            :||.||:.|.:...|| ||.:.....:..|....|.|:|::..|:.::.:...      :.|...
Human    24 LLILLLLLIKAAQLYL-HRQWLLKALQQFPCPPSHWLFGHIQEFQHDQELQRI------QERVKT 81

  Fly    68 FPFVGFYFL--HKPAAFIVDTQLAKNILIKDFSNFADRGQFHNGRDDP------------LTQHL 118
            ||....|::  .|....:.|....|.||               ||.||            :...|
Human    82 FPSACPYWIWGGKVRVQLYDPDYMKVIL---------------GRSDPKSHGSYKFLAPRIGYGL 131

  Fly   119 FNLDGKKWKDMRQRLTPTFTSGKMK----FMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELM 179
            ..|:|:.|...|:.|||.|.:..:|    .|..:|..:.:::.:::.:..|       ||:.:.:
Human   132 LLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSP-------LEVFQHV 189

  Fly   180 ARFTTDVIGTCAFG------IECNTLR--TPVSDFRTMGQKVFTDMRHGKLLTMFVFSFPKLASR 236
            :..|.|.|...||.      ::.|:..  ..:||..::   ||..||:.......::|... |.|
Human   190 SLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSL---VFCCMRNAFHENDTIYSLTS-AGR 250

  Fly   237 LRMRMMPEDVHQFFMRLVNDTIALR--------ERENFKRN---DFMNLLIELKQKGRVTLDNGE 290
            ...|.. :..||.    .:..|.||        |.|..||.   ||:::|:..|      ::||.
Human   251 WTHRAC-QLAHQH----TDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK------MENGS 304

  Fly   291 VIEGMDIGELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQEGQLTYES 355
            ::...|   |.|:|..|...|.:|::|.:|:.||.||.:...|:|.|.||..:|.: ...:|:..
Human   305 ILSDKD---LRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGD-GASITWNH 365

  Fly   356 IKAMTYLNQVISETLRLYTLVPHLERKALNDYVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNP 420
            :..|.|....|.|.||||..||.:.|:.......|....|  .||..|::.....|.:..::||.
Human   366 LDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSL--PKGIMVLLSIYGLHHNPKVWPNL 428

  Fly   421 ETFDPERFSPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLK 485
            |.|||.||:|.  :|:.|..:|||..|.|||||.:|...|.::..|..:.||.: :.|.|.||:
Human   429 EVFDPSRFAPG--SAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFEL-LPDPTRIPI- 489

  Fly   486 YSPMS-IVLGTVGGIYLRVERI 506
              ||: :||.:..||:||:.|:
Human   490 --PMARLVLKSKNGIHLRLRRL 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	135/503 (27%)
CYP4A22	NP_001010969.2	p450	52..505	CDD:278495	136/507 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900