Protein Alignment Cyp6a2 and Cyp4a12a

DIOPT Version :9

• Sequence 1: NP_523628.1
• Gene: Cyp6a2 / 35587
• FlyBaseID: FBgn0000473
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_803125.2
• Gene: Cyp4a12a / 277753
• MGIID: 88612
• Length: 508
• Species: Mus musculus
• Alignment Length: 553
• Identity: 143/553 - (25%)
• Similarity: 237/553 - (42%)
• Gaps: 118/553 - (21%)

  Fly     3 VLIYLLIAISSLLAYLYHRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRVMHDFFYDYYNKYRKSG 67
            ||..||:...:...|| ||.:...:.:..|....|.|:|:.:  .|::.:.|..      .|...
Mouse    24 VLSLLLLLFKTAQLYL-HRQWLLSSTQQFPSPPSHWLFGHKI--LKDQDLQDIL------TRIKN 79

  Fly    68 FPFVGFYFL--HKPAAFIVDTQLAKNILIKDFSNFADRGQFHNGRDDP------------LTQHL 118
            ||.....:|  .|....:.|....|.||               ||.||            :.:.|
Mouse    80 FPSACPQWLWGSKVRIQVYDPDYMKLIL---------------GRSDPKANGSYRFLAPWIGRGL 129

  Fly   119 FNLDGKKWKDMRQRLTPTFTSGKMKFMFPTVIKVSEEFVKVIT---EQVPAAQNGAVLEIKELMA 180
            ..|||:.|...|:.|||.|....:|    ...::..:.|:|:.   ||:  ....:.|||...:.
Mouse   130 LMLDGQTWFQHRRMLTPAFHYDILK----PYTEIMADSVRVMLDKWEQI--VGQDSTLEIFRHIT 188

  Fly   181 RFTTDVIGTCAFGIECNT-----LRTPVSDFRTMGQKVFTDMRHGKLLTMFVF------------ 228
            ..|.|.|..|||..|.:.     .::.:.....:...||:.:|:       :|
Mouse   189 LMTLDTIMKCAFSHEGSVQLDRKYKSYIQAVEDLNDLVFSRVRN-------IFHQNDIIYRVSSN 246

  Fly   229 -----SFPKLA---------SRLRMRMMPEDVHQFFMRLVNDTIALRERENFKRNDFMNLLIELK 279
                 |..|||         || |:::..|:             .|.:.:..:|.||:::|:..:
Mouse   247 GCKANSACKLAHDHTDQVIKSR-RIQLQDEE-------------ELEKLKKKRRLDFLDILLFAR 297

  Fly   280 QKGRVTLDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTVL 344
                  ::||:.:...|   |.|:|..|...|.:|::|.:|:..|.||.|.:.|.|.|.|||::|
Mouse   298 ------MENGKSLSDKD---LRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSLL 353

  Fly   345 EEQEGQLTYESIKAMTYLNQVISETLRLYTLVPHLERKALNDYVVPGHEKLVIEKGTQVIIPACA 409
            .:.. .:|:..:..|.|....|.|.||:|..||.:.|:..:....|....|  .||..|::....
Mouse   354 GDGT-SITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPVTFPDGRSL--PKGIHVMLSFYG 415

  Fly   410 YHRDEDLYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRV 474
            .|.:..::||||.|||.||:|.  ::|.|..:|||..|.|||||.:|...:.::.:|..:.||.:
Mouse   416 LHHNPTVWPNPEVFDPSRFAPG--SSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFEL 478

  Fly   475 SVCDTTEIPLKYSPM-SIVLGTVGGIYLRVERI 506
             :.|.|.:|:   |: .|||.:..||:|.::::
Mouse   479 -LPDPTRVPI---PIPRIVLKSKNGIHLHLKKL 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	133/514 (26%)
Cyp4a12a	NP_803125.2	p450	52..502	CDD:278495	134/517 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900