Protein Alignment Cyp6a2 and Cyp4v3

DIOPT Version :10

• Sequence 1: NP_523628.1
• Gene: Cyp6a2 / 35587
• FlyBaseID: FBgn0000473
• Length: 506
• Species: Drosophila melanogaster
• Sequence 2: NP_001129072.1
• Gene: Cyp4v3 / 266761
• RGDID: 708530
• Length: 525
• Species: Rattus norvegicus
• Alignment Length: 553
• Identity: 140/553 - (25%)
• Similarity: 225/553 - (40%)
• Gaps: 117/553 - (21%)

  Fly     7 LLIAISSLLAYLYHRNFNYWNR-RGVPHDA-PHPLYGNMVGFRKNRVMHDFF---YDYYNKYRKS 66
            ||..:..|::|.     ..|.: |.:|..| .:||.|:.:..:.|..  :||   ..|..::|.
  Rat    30 LLNILQMLVSYA-----RKWQQMRPIPSVARAYPLVGHALFMKPNNT--EFFQQIIQYTEEFRH- 86

  Fly    67 GFPFVGFYFLHKPAAFIVDTQLAKNI-LIKDFSNFADRGQFHNGRDDPLTQHLFNLDGKKWKDMR 130
             .|.:..:....|   :|....|:|: :|...|...|:...:......|...|....|.||:..|
  Rat    87 -LPIIKLWIGPVP---LVALYKAENVEVILTSSKQIDKSFMYKFLQPWLGLGLLTSTGSKWRARR 147

  Fly   131 QRLTPTFTSGKMKFMFPTVIKVSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDV------IGT 189
            :.|||:|.           ..:.|:|:.|:.||       |.:.:.:|......:.      |..
  Rat   148 KMLTPSFH-----------FTILEDFLDVMNEQ-------ANILVNKLEKHVNQEAFNCFFPITL 194

  Fly   190 CAFGIECNTLRTPVSDFRTMGQKVFTDMRHGKLLTMFVFSFPKLASRLRMRMMP----------- 243
            ||..|.|.|         .||:.:.............|:....:..| ||: ||
  Rat   195 CALDIICET---------AMGKNIGAQSNGDSEYVRTVYRMSDMIYR-RMK-MPWFWFDLWYLMF 248

  Fly   244 ----------EDVHQFFMRLVNDTIALRERE-------------NFKRNDFMNLLIELKQKGRVT 285
                      :.:|.|...::.:.:..|:.|             ..||..|::||:.      ||
  Rat   249 KEGRDHKKGLKSLHTFTNNVIAERVNARKAEQDCIGAGRGPLPSKTKRKAFLDLLLS------VT 307

  Fly   286 LDNGEVIEGMDIGELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQEGQ 350
            .:.|..:...||.|   :|..|...|.:|:::.:::.||.|..|.::|.::..|:..|.......
  Rat   308 DEEGNKLSHEDIRE---EVDTFMFEGHDTTAAAINWSLYLLGSNPEVQRKVDKELDDVFGRSHRP 369

  Fly   351 LTYESIKAMTYLNQVISETLRLYTLVPHLERKALNDYVVPGHEKLVIEKGTQVIIPACAYHRDED 415
            :|.|.:|.:.||:.||.||||::..||...|....|..|.|::   |.|||:.:|...|.|||..
  Rat   370 VTLEDLKKLKYLDCVIKETLRVFPSVPLFARSLSEDCEVAGYK---ISKGTEAVIIPYALHRDPR 431

  Fly   416 LYPNPETFDPERFSPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRVSVCDTT 480
            .:|:||.|.||||.||....|....::||..|||||||.:|..|:.:..||.|:..|.:......
  Rat   432 YFPDPEEFQPERFFPENSQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILACILREFWIESNQKR 496

  Fly   481 EIPLKYSPMSIVLGTVG--------GIYLRVER 505
            |          .||..|        ||:::::|
  Rat   497 E----------ELGLAGDLILRPNNGIWIKLKR 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6a2	NP_523628.1	CYP6-like	69..500	CDD:410679	122/479 (25%)
Cyp4v3	NP_001129072.1	CYP4V	76..515	CDD:410773	125/494 (25%)